Gene Symbol: I2L
Description: temporal expression: late
Alias: IMV membrane protein
Species: Vaccinia virus
Products:     I2L

Top Publications

  1. Nichols R, Stanitsa E, Unger B, Traktman P. The vaccinia virus gene I2L encodes a membrane protein with an essential role in virion entry. J Virol. 2008;82:10247-61 pubmed publisher
    The previously unstudied vaccinia virus gene I2L is conserved in all orthopoxviruses...
  2. Qin L, Liang M, Evans D. Genomic analysis of vaccinia virus strain TianTan provides new insights into the evolution and evolutionary relationships between Orthopoxviruses. Virology. 2013;442:59-66 pubmed publisher
    ..Phylogenetic methods show that TianTan belongs to a unique clade of VACV, but probably also share a common origin with strains belonging to the Copenhagen/Lister lineage and distinct from the Wyeth/Dryvax lineage. ..
  3. Hyun S, Weisberg A, Moss B. Deletion of the Vaccinia Virus I2 Protein Interrupts Virion Morphogenesis, Leading to Retention of the Scaffold Protein and Mislocalization of Membrane-Associated Entry Proteins. J Virol. 2017;91: pubmed publisher
    The I2L open reading frame of vaccinia virus (VACV) encodes a conserved 72-amino-acid protein with a putative C-terminal transmembrane domain...