F2L

Summary

Gene Symbol: F2L
Description: temporal expression: early
Alias: dUTPase
Species: Vaccinia virus
Products:     F2L

Top Publications

  1. Prichard M, Kern E, Quenelle D, Keith K, Moyer R, Turner P. Vaccinia virus lacking the deoxyuridine triphosphatase gene (F2L) replicates well in vitro and in vivo, but is hypersensitive to the antiviral drug (N)-methanocarbathymidine. Virol J. 2008;5:39 pubmed publisher
    The vaccinia virus (VV) F2L gene encodes a functional deoxyuridine triphosphatase (dUTPase) that catalyzes the conversion of dUTP to dUMP and is thought to minimize the incorporation of deoxyuridine residues into the viral genome...
  2. Roseman N, Slabaugh M. The vaccinia virus HindIII F fragment: nucleotide sequence of the left 6.2 kb. Virology. 1990;178:410-8 pubmed
    ..Two of these ORFs have been reported previously. ORF F4L encodes the small subunit of ribonucleotide reductase and ORF F2L is homologous to a retroviral protease-like gene.
  3. De Silva F, Moss B. Effects of vaccinia virus uracil DNA glycosylase catalytic site and deoxyuridine triphosphatase deletion mutations individually and together on replication in active and quiescent cells and pathogenesis in mice. Virol J. 2008;5:145 pubmed publisher
    ..Deoxyuridine triphosphatase (dUTPase) hydrolyzes dUTP, generating dUMP for biosynthesis of thymidine nucleotides while decreasing the availability of ..
  4. Qin L, Favis N, Famulski J, Evans D. Evolution of and evolutionary relationships between extant vaccinia virus strains. J Virol. 2015;89:1809-24 pubmed publisher
    ..Based on these findings, it is possible that all existing strains of VACV are derived from a single complex stock of viruses that has been passaged, distributed, and sampled over time. ..