Gene Symbol: C7L
Description: host-range protein
Species: Vaccinia virus
Products:     C7L

Top Publications

  1. Garcel A, Crance J, Drillien R, Garin D, Favier A. Genomic sequence of a clonal isolate of the vaccinia virus Lister strain employed for smallpox vaccination in France and its comparison to other orthopoxviruses. J Gen Virol. 2007;88:1906-16 pubmed
    ..These studies highlight the heterogeneity between VACV strains and provide a basis to better understand differences in safety and efficacy of smallpox vaccines. ..
  2. Meng X, Jiang C, Arsenio J, Dick K, Cao J, Xiang Y. Vaccinia virus K1L and C7L inhibit antiviral activities induced by type I interferons. J Virol. 2009;83:10627-36 pubmed publisher
    Cellular tropism of vaccinia virus (VACV) is regulated by host range genes, including K1L, C7L, and E3L...
  3. Backes S, Sperling K, Zwilling J, Gasteiger G, Ludwig H, Kremmer E, et al. Viral host-range factor C7 or K1 is essential for modified vaccinia virus Ankara late gene expression in human and murine cells, irrespective of their capacity to inhibit protein kinase R-mediated phosphorylation of eukaryotic translation initiation . J Gen Virol. 2010;91:470-82 pubmed publisher
    ..This study revealed that the host-range genes K1L and C7L also prevent eIF2alpha phosphorylation in modified VACV Ankara (MVA) infection of several human and murine cell ..
  4. Meng X, Schoggins J, Rose L, Cao J, Ploss A, Rice C, et al. C7L family of poxvirus host range genes inhibits antiviral activities induced by type I interferons and interferon regulatory factor 1. J Virol. 2012;86:4538-47 pubmed publisher
    Vaccinia virus (VACV) K1L and C7L function equivalently in many mammalian cells to support VACV replication and antagonize antiviral activities induced by type I interferons (IFNs)...
  5. Terajima M, Urban S, Leporati A. The N-terminus of vaccinia virus host range protein C7L is essential for function. Virus Genes. 2013;46:20-7 pubmed publisher
    ..The host range of wild type VACV is very broad among mammalian cells. C7L is a host range gene identified in VACV and is well conserved in mammalian poxviruses except for parapoxviruses and ..
  6. Qin L, Favis N, Famulski J, Evans D. Evolution of and evolutionary relationships between extant vaccinia virus strains. J Virol. 2015;89:1809-24 pubmed publisher
    ..Based on these findings, it is possible that all existing strains of VACV are derived from a single complex stock of viruses that has been passaged, distributed, and sampled over time. ..