Gene Symbol: B1R
Description: temporal expression: early
Alias: ser/thr kinase
Species: Vaccinia virus
Wiebe M, Traktman P. Poxviral B1 kinase overcomes barrier to autointegration factor, a host defense against virus replication. Cell Host Microbe. 2007;1:187-97 pubmed publisher
..To enable the virus to evade this defense, the poxviral B1 has evolved to usurp a signaling pathway employed by the host cell...
Qin L, Favis N, Famulski J, Evans D. Evolution of and evolutionary relationships between extant vaccinia virus strains. J Virol. 2015;89:1809-24 pubmed publisher
..Based on these findings, it is possible that all existing strains of VACV are derived from a single complex stock of viruses that has been passaged, distributed, and sampled over time. ..
Jamin A, Ibrahim N, Wicklund A, Weskamp K, Wiebe M. Vaccinia Virus B1 Kinase Is Required for Postreplicative Stages of the Viral Life Cycle in a BAF-Independent Manner in U2OS Cells. J Virol. 2015;89:10247-59 pubmed publisher
The vaccinia virus B1R gene encodes a highly conserved protein kinase that is essential for the poxviral life cycle...
Santos C, Vega F, Blanco S, Barcia R, Lazo P. The vaccinia virus B1R kinase induces p53 downregulation by an Mdm2-dependent mechanism. Virology. 2004;328:254-65 pubmed publisher
..To understand viral pathogenesis, it is necessary to know how viral proteins interact with host proteins. The B1R kinase is an early viral gene required for vaccinia virus DNA synthesis and replication, but no cellular substrate ..
Ibrahim N, Wicklund A, Jamin A, Wiebe M. Barrier to autointegration factor (BAF) inhibits vaccinia virus intermediate transcription in the absence of the viral B1 kinase. Virology. 2013;444:363-73 pubmed publisher
..These studies expand our understanding of the role of the B1 kinase during infection and provide the first evidence that BAF is a defense against viral gene expression...
Olson A, Rico A, Wang Z, Delhon G, Wiebe M. Deletion of the Vaccinia Virus B1 Kinase Reveals Essential Functions of This Enzyme Complemented Partly by the Homologous Cellular Kinase VRK2. J Virol. 2017;91: pubmed publisher
..As a result, we have discovered that B1 and VRK2 target a common set of substrates vital to productive infection of this large cytoplasmic DNA virus. ..
Jha S, Rollins M, Fuchs G, Procter D, HALL E, Cozzolino K, et al
. Trans-kingdom mimicry underlies ribosome customization by a poxvirus kinase. Nature. 2017;546:651-655 pubmed publisher
..Our findings provide insight into ribosome customization through trans-kingdom mimicry and the mechanics of species-specific leader activity that underlie poxvirus polyA-leaders. ..