Gene Symbol: A27L
Description: temporal expression: late
Alias: IMV surface protein
Species: Vaccinia virus
Osborne J, Da Silva M, Frace A, Sammons S, Olsen Rasmussen M, Upton C, et al
. Genomic differences of Vaccinia virus clones from Dryvax smallpox vaccine: the Dryvax-like ACAM2000 and the mouse neurovirulent Clone-3. Vaccine. 2007;25:8807-32 pubmed
..The sequence information for ACAM2000 and CL3 could be significant for resolving the dynamics of their different proteomes and thereby aid development of safer, more effective vaccines. ..
Chang S, Chang Y, Izmailyan R, Tang Y, Chang W. Vaccinia virus A25 and A26 proteins are fusion suppressors for mature virions and determine strain-specific virus entry pathways into HeLa, CHO-K1, and L cells. J Virol. 2010;84:8422-32 pubmed publisher
..Our results also suggest that during virion morphogenesis, the incorporation of the A25 and A26 proteins into mature virions may help restrain viral fusion activity until the time of infections. ..
Dashprakash M, Venkatesan G, Ramakrishnan M, Muthuchelvan D, Sankar M, Pandey A, et al
. Genetic diversity of fusion gene (ORF 117), an analogue of vaccinia virus A27L gene of capripox virus isolates. Virus Genes. 2015;50:325-8 pubmed publisher
Zhang Q, Tian M, Feng Y, Zhao K, Xu J, Liu Y, et al
. Genomic sequence and virulence of clonal isolates of vaccinia virus Tiantan, the Chinese smallpox vaccine strain. PLoS ONE. 2013;8:e60557 pubmed publisher
..The complete genome sequences, ORF annotations, and phenotypic diversity yielded from this study aid our understanding of the Chinese historic TT strain and are useful for HIV vaccine projects employing TT as a vector. ..
Chang T, Chang S, Hsieh F, Ko T, Lin C, Ho M, et al
. Crystal structure of vaccinia viral A27 protein reveals a novel structure critical for its function and complex formation with A26 protein. PLoS Pathog. 2013;9:e1003563 pubmed publisher
..Because A27 is a neutralizing target, structural information will aid the development of inhibitors to block A27 self-assembly or complex formation against vaccinia virus infection. ..
FernÃ¡ndez Escobar M, NÃ¡jera J, Baldanta S, Rodriguez D, Way M, Esteban M, et al
. Suppression of NYVAC Infection in HeLa Cells Requires RNase L but Is Independent of Protein Kinase R Activity. J Virol. 2016;90:2135-41 pubmed publisher
..in the abortive infection of human HeLa cells with the poxvirus strain NYVAC, for which an inhibition of viral A27L and B5R gene expression is described...