Gene Symbol: A17L
Description: temporal expression: late
Alias: IMV membrane protein
Species: Vaccinia virus
Unger B, Mercer J, Boyle K, Traktman P. Biogenesis of the vaccinia virus membrane: genetic and ultrastructural analysis of the contributions of the A14 and A17 proteins. J Virol. 2013;87:1083-97 pubmed publisher
..Precleavage of the C terminus or abrogation of its phosphorylation diminished the IV?MV maturation; a block to cleavage spared virion maturation but compromised the yield of infectious virus...
Zhang Q, Tian M, Feng Y, Zhao K, Xu J, Liu Y, et al
. Genomic sequence and virulence of clonal isolates of vaccinia virus Tiantan, the Chinese smallpox vaccine strain. PLoS ONE. 2013;8:e60557 pubmed publisher
..The complete genome sequences, ORF annotations, and phenotypic diversity yielded from this study aid our understanding of the Chinese historic TT strain and are useful for HIV vaccine projects employing TT as a vector. ..
Wang D, Hsiao J, Wong C, Li G, Lin S, Yu S, et al
. Vaccinia viral protein A27 is anchored to the viral membrane via a cooperative interaction with viral membrane protein A17. J Biol Chem. 2014;289:6639-55 pubmed publisher
..Using these results in combination with site-directed mutagenesis data, we established a computer model to explain the specific A27-A17 binding mechanism. ..
Medaglia M, MoussatchÃ© N, Nitsche A, Dabrowski P, Li Y, Damon I, et al
. Genomic Analysis, Phenotype, and Virulence of the Historical Brazilian Smallpox Vaccine Strain IOC: Implications for the Origins and Evolutionary Relationships of Vaccinia Virus. J Virol. 2015;89:11909-25 pubmed publisher
..Our data expand the discussion on the origins and evolutionary connections of VACV lineages. ..