ugpA

Summary

Gene Symbol: ugpA
Description: glycerol-3-phosphate transporter subunit
Alias: ECK3436, JW3417, psiB, psiC
Species:

Top Publications

  1. ncbi Carbon-starvation induction of the ugp operon, encoding the binding protein-dependent sn-glycerol-3-phosphate transport system in Escherichia coli
    T Z Su
    Department of Biological Chemistry, University of Michigan, Ann Arbor 48109 0606
    Mol Gen Genet 230:28-32. 1991
  2. ncbi Structural comparison of lactose permease and the glycerol-3-phosphate antiporter: members of the major facilitator superfamily
    Jeff Abramson
    Department of Biological Sciences, Imperial College London, London SW7 2AZ, UK
    Curr Opin Struct Biol 14:413-9. 2004
  3. ncbi The structural basis of substrate translocation by the Escherichia coli glycerol-3-phosphate transporter: a member of the major facilitator superfamily
    M Joanne Lemieux
    Skirball Institute of Biomolecular Medicine and Department of Cell Biology, New York University School of Medicine, 540 First Avenue, New York, New York 10016, USA
    Curr Opin Struct Biol 14:405-12. 2004
  4. ncbi Binding protein-dependent ABC transport system for glycerol 3-phosphate of Escherichia coli
    W Boos
    Faculty of Biology, University of Konstanz, Germany
    Methods Enzymol 292:40-51. 1998
  5. ncbi A second transport system for sn-glycerol-3-phosphate in Escherichia coli
    M Argast
    J Bacteriol 136:1070-83. 1978
  6. ncbi Functional exchangeability of the ABC proteins of the periplasmic binding protein-dependent transport systems Ugp and Mal of Escherichia coli
    D Hekstra
    Department of Molecular Cell Biology, Utrecht University, The Netherlands
    J Bacteriol 175:6546-52. 1993
  7. ncbi The pho regulon-dependent Ugp uptake system for glycerol-3-phosphate in Escherichia coli is trans inhibited by Pi
    P Brzoska
    Department of Biology, University of Konstanz, Germany
    J Bacteriol 176:15-20. 1994
  8. ncbi Kinetic analysis by in vivo 31P nuclear magnetic resonance of internal Pi during the uptake of sn-glycerol-3-phosphate by the pho regulon-dependent Ugp system and the glp regulon-dependent GlpT system
    K B Xavier
    Instituto de Tecnologia Quimica e Biologica, UNL, Oeiras, Portugal
    J Bacteriol 177:699-704. 1995
  9. ncbi Effects of halo analogs of glycerol 3-phosphate and dihydroxyacetone phosphate upon Escherichia coli
    B Mildener
    Antimicrob Agents Chemother 19:678-81. 1981
  10. ncbi Characterization of the ugp region containing the genes for the phoB dependent sn-glycerol-3-phosphate transport system of Escherichia coli
    H Schweizer
    Mol Gen Genet 197:161-8. 1984

Detail Information

Publications17

  1. ncbi Carbon-starvation induction of the ugp operon, encoding the binding protein-dependent sn-glycerol-3-phosphate transport system in Escherichia coli
    T Z Su
    Department of Biological Chemistry, University of Michigan, Ann Arbor 48109 0606
    Mol Gen Genet 230:28-32. 1991
    ..This conclusion is supported by the fact that pho-independent ugp expression correlated with the presence of the cya and crp gene products...
  2. ncbi Structural comparison of lactose permease and the glycerol-3-phosphate antiporter: members of the major facilitator superfamily
    Jeff Abramson
    Department of Biological Sciences, Imperial College London, London SW7 2AZ, UK
    Curr Opin Struct Biol 14:413-9. 2004
    ..All three structures reveal 12 transmembrane helices forming two distinct domains, and could imply that members of this superfamily have preserved both secondary and tertiary structure elements during evolution...
  3. ncbi The structural basis of substrate translocation by the Escherichia coli glycerol-3-phosphate transporter: a member of the major facilitator superfamily
    M Joanne Lemieux
    Skirball Institute of Biomolecular Medicine and Department of Cell Biology, New York University School of Medicine, 540 First Avenue, New York, New York 10016, USA
    Curr Opin Struct Biol 14:405-12. 2004
    ..The structure and mechanism of the glycerol-3-phosphate transporter form a paradigm for other members of the major facilitator superfamily...
  4. ncbi Binding protein-dependent ABC transport system for glycerol 3-phosphate of Escherichia coli
    W Boos
    Faculty of Biology, University of Konstanz, Germany
    Methods Enzymol 292:40-51. 1998
  5. ncbi A second transport system for sn-glycerol-3-phosphate in Escherichia coli
    M Argast
    J Bacteriol 136:1070-83. 1978
    ..The mutation ugp+, which was responsible for the appearance of the new transport system and the appearance of GP 1, 2, and 3 in the periplasm was cotransducible with araD by phage P1 transduction and was recessive in merodiploids...
  6. ncbi Functional exchangeability of the ABC proteins of the periplasmic binding protein-dependent transport systems Ugp and Mal of Escherichia coli
    D Hekstra
    Department of Molecular Cell Biology, Utrecht University, The Netherlands
    J Bacteriol 175:6546-52. 1993
    ..that it was expressed at a sufficiently high level in the absence of the integral inner membrane components UgpA and/or UgpE of the Ugp system...
  7. ncbi The pho regulon-dependent Ugp uptake system for glycerol-3-phosphate in Escherichia coli is trans inhibited by Pi
    P Brzoska
    Department of Biology, University of Konstanz, Germany
    J Bacteriol 176:15-20. 1994
    ..5 mM. Cells had to be starved for Pi in order to observe this inhibition. We conclude that the activity of the Ugp transport system is controlled by the level of internal phosphate...
  8. ncbi Kinetic analysis by in vivo 31P nuclear magnetic resonance of internal Pi during the uptake of sn-glycerol-3-phosphate by the pho regulon-dependent Ugp system and the glp regulon-dependent GlpT system
    K B Xavier
    Instituto de Tecnologia Quimica e Biologica, UNL, Oeiras, Portugal
    J Bacteriol 177:699-704. 1995
    ..Both systems were inversely controlled by internal Pi. Whereas the Ugp system was inhibited, the GlpT system was stimulated by elevated internal Pi...
  9. ncbi Effects of halo analogs of glycerol 3-phosphate and dihydroxyacetone phosphate upon Escherichia coli
    B Mildener
    Antimicrob Agents Chemother 19:678-81. 1981
    ..The fluoro and chloro analogs of glycerol 3-phosphate inhibit the growth of Escherichia coli and affect bacterial enzymes involved in lipid synthesis...
  10. ncbi Characterization of the ugp region containing the genes for the phoB dependent sn-glycerol-3-phosphate transport system of Escherichia coli
    H Schweizer
    Mol Gen Genet 197:161-8. 1984
    ..are organized in two separate operons which comprise at least four genes: ugpB and ugpD constitute one operon, ugpA and ugpC constitute the other. The structural gene for the G3P binding protein (G3PBP) is ugpB...
  11. ncbi Mapping of two ugp genes coding for the pho regulon-dependent sn-glycerol-3-phosphate transport system of Escherichia coli
    H Schweizer
    J Bacteriol 150:1164-71. 1982
    Two genes, ugpA and ugpB, coding for a binding protein-dependent sn-glycerol-3-phosphate transport system, were mapped at 75.3 min on the Escherichia coli chromosome...
  12. ncbi Cloning of the ugp region containing the structural genes for the pho regulon-dependent sn-glycerol-3-phosphate transport system of Escherichia coli
    H Schweizer
    Mol Gen Genet 192:177-86. 1983
    ..Using ugp-lacZ fusions, it could be shown that the ugp region consists of at least two different operons that are transcribed in the same direction (counterclockwise) on the E. coli chromosome...
  13. ncbi Fluorouracil and the isolation of mutants lacking uridine phosphorylase in Escherichia coli: location of the gene
    R H Pritchard
    Mol Gen Genet 111:84-8. 1971
  14. ncbi Nucleotide sequence of the ugp genes of Escherichia coli K-12: homology to the maltose system
    P Overduin
    Department of Molecular Cell Biology, State University of Utrecht, The Netherlands
    Mol Microbiol 2:767-75. 1988
    ..The sequences of the proteins contain the characteristics of several other binding protein-dependent transport systems, but they seem to be particularly closely related to the maltose system...
  15. ncbi Possible involvement of the ugpA gene product in the stable maintenance of mini-F plasmid in Escherichia coli
    B Ezaki
    Department of Molecular Genetics, Kumamoto University Medical School, Japan
    Mol Gen Genet 223:361-8. 1990
    ..the seg-3 mutant carried two mutations that additively affected the maintenance of mini-F plasmid; one was in the ugpA gene and the other was presumably in the rpoH gene...
  16. ncbi Dual regulation of the ugp operon by phosphate and carbon starvation at two interspaced promoters
    M Kasahara
    Department of Experimental Chemotherapy, Osaka University, Japan
    J Bacteriol 173:549-58. 1991
    ..These results suggest that the two promoters function alternately in responding to phosphate or carbon starvation, thus providing the cell with a means to adapt to these physiological stresses...
  17. ncbi Uptake of glycerol-2-phosphate via the ugp-encoded transporter in Escherichia coli K-12
    Kechao Yang
    Department of Microbiology, University of Illinois at Urbana Champaign, Urbana, IL 61801, USA
    J Bacteriol 191:4667-70. 2009
    ..Mutations in the ugpBAECQ operon eliminated this phenotype, suggesting that G2P is a previously unrecognized substrate for the binding protein-dependent Ugp transporter...