Tb11.01.5940

Summary

Gene Symbol: Tb11.01.5940
Description: exportin 1
Alias: exportin 1
Species: Trypanosoma brucei TREU927

Top Publications

  1. Zeiner G, Sturm N, Campbell D. Exportin 1 mediates nuclear export of the kinetoplastid spliced leader RNA. Eukaryot Cell. 2003;2:222-30 pubmed
    ..and eliminated the cytoplasmic SL RNA, suggesting that cytoplasmic SL RNA was dependent on the nuclear exporter exportin 1 (XPO1). Ectopic expression of xpo1 with a C506S mutation in T. brucei conferred resistance to leptomycin B...
  2. Biton M, Mandelboim M, Arvatz G, Michaeli S. RNAi interference of XPO1 and Sm genes and their effect on the spliced leader RNA in Trypanosoma brucei. Mol Biochem Parasitol. 2006;150:132-43 pubmed publisher
    ..Only after massive nuclear accumulation is the 'defective' SL RNA exported to the cytoplasm to form SL RNP-C, which may be a route to dispose of SL RNA when its normal biogenesis is blocked...
  3. Hellman K, Prohaska K, Williams N. Trypanosoma brucei RNA binding proteins p34 and p37 mediate NOPP44/46 cellular localization via the exportin 1 nuclear export pathway. Eukaryot Cell. 2007;6:2206-13 pubmed
    ..acid sequences revealed a leucine-rich nuclear export signal, which interacts with the nuclear export factor exportin 1. Immune capture experiments demonstrated that p34, p37, and NOPP44/46 associate with exportin 1...

Detail Information

Publications3

  1. Zeiner G, Sturm N, Campbell D. Exportin 1 mediates nuclear export of the kinetoplastid spliced leader RNA. Eukaryot Cell. 2003;2:222-30 pubmed
    ..and eliminated the cytoplasmic SL RNA, suggesting that cytoplasmic SL RNA was dependent on the nuclear exporter exportin 1 (XPO1). Ectopic expression of xpo1 with a C506S mutation in T. brucei conferred resistance to leptomycin B...
  2. Biton M, Mandelboim M, Arvatz G, Michaeli S. RNAi interference of XPO1 and Sm genes and their effect on the spliced leader RNA in Trypanosoma brucei. Mol Biochem Parasitol. 2006;150:132-43 pubmed publisher
    ..Only after massive nuclear accumulation is the 'defective' SL RNA exported to the cytoplasm to form SL RNP-C, which may be a route to dispose of SL RNA when its normal biogenesis is blocked...
  3. Hellman K, Prohaska K, Williams N. Trypanosoma brucei RNA binding proteins p34 and p37 mediate NOPP44/46 cellular localization via the exportin 1 nuclear export pathway. Eukaryot Cell. 2007;6:2206-13 pubmed
    ..acid sequences revealed a leucine-rich nuclear export signal, which interacts with the nuclear export factor exportin 1. Immune capture experiments demonstrated that p34, p37, and NOPP44/46 associate with exportin 1...