Gene Symbol: Tb11.01.5940
Description: exportin 1
Alias: exportin 1
Species: Trypanosoma brucei TREU927
- Zeiner G, Sturm N, Campbell D. Exportin 1 mediates nuclear export of the kinetoplastid spliced leader RNA. Eukaryot Cell. 2003;2:222-30 pubmed..and eliminated the cytoplasmic SL RNA, suggesting that cytoplasmic SL RNA was dependent on the nuclear exporter exportin 1 (XPO1). Ectopic expression of xpo1 with a C506S mutation in T. brucei conferred resistance to leptomycin B...
- Biton M, Mandelboim M, Arvatz G, Michaeli S. RNAi interference of XPO1 and Sm genes and their effect on the spliced leader RNA in Trypanosoma brucei. Mol Biochem Parasitol. 2006;150:132-43 pubmed publisher..Only after massive nuclear accumulation is the 'defective' SL RNA exported to the cytoplasm to form SL RNP-C, which may be a route to dispose of SL RNA when its normal biogenesis is blocked...
- Hellman K, Prohaska K, Williams N. Trypanosoma brucei RNA binding proteins p34 and p37 mediate NOPP44/46 cellular localization via the exportin 1 nuclear export pathway. Eukaryot Cell. 2007;6:2206-13 pubmed..acid sequences revealed a leucine-rich nuclear export signal, which interacts with the nuclear export factor exportin 1. Immune capture experiments demonstrated that p34, p37, and NOPP44/46 associate with exportin 1...