ATP dependent phosphofructokinase

Summary

Gene Symbol: ATP dependent phosphofructokinase
Description: ATP-dependent phosphofructokinase
Alias: Tb03.3K10.320
Species: Trypanosoma brucei brucei strain 927/4 GUTat10.1

Top Publications

  1. ncbi The glycosomal ATP-dependent phosphofructokinase of Trypanosoma brucei must have evolved from an ancestral pyrophosphate-dependent enzyme
    P A Michels
    International Institute of Cellular and Molecular Pathology and Laboratory of Biochemistry, Catholic University of Louvain, Brussels, Belgium
    Eur J Biochem 250:698-704. 1997
  2. ncbi Exploring the active site of Trypanosoma brucei phosphofructokinase by inhibition studies: specific irreversible inhibition
    Samantha Claustre
    Laboratoire Synthèse et Physico Chimie de Molécules d Intérêt Biologique UMR CNRS 5068, Universite Paul Sabatier, 118 route de Narbonne, 31062 Toulouse Cedex, France
    Biochemistry 41:10183-93. 2002

Scientific Experts

  • P A Michels
  • Samantha Claustre
  • Nathalie Chevalier
  • Jacques Perie
  • Michele Willson
  • Claudia Lopez
  • Colette Denier
  • Faouzi Lakhdar-Ghazal
  • Andrée Lougare

Detail Information

Publications2

  1. ncbi The glycosomal ATP-dependent phosphofructokinase of Trypanosoma brucei must have evolved from an ancestral pyrophosphate-dependent enzyme
    P A Michels
    International Institute of Cellular and Molecular Pathology and Laboratory of Biochemistry, Catholic University of Louvain, Brussels, Belgium
    Eur J Biochem 250:698-704. 1997
    ..brucei PFK shows many structural differences, even at the active site, when compared with other ATP-dependent PFKs. These differences offer great potential for the structure-based design of trypanocidal drugs...
  2. ncbi Exploring the active site of Trypanosoma brucei phosphofructokinase by inhibition studies: specific irreversible inhibition
    Samantha Claustre
    Laboratoire Synthèse et Physico Chimie de Molécules d Intérêt Biologique UMR CNRS 5068, Universite Paul Sabatier, 118 route de Narbonne, 31062 Toulouse Cedex, France
    Biochemistry 41:10183-93. 2002
    ..This first example of a specific irreversible inactivation of T. brucei PFK offers an opportunity to develop biologically active compounds against the sleeping sickness, the causative agent of which is the trypanosome...