Gene Symbol: eIF4E1
Description: translation initiation factor eIF4E1
Alias: eIF4E, eukaryotic translation initiation factor 4E
Ruffel S, Gallois J, Lesage M, Caranta C. The recessive potyvirus resistance gene pot-1 is the tomato orthologue of the pepper pvr2-eIF4E gene. Mol Genet Genomics. 2005;274:346-53 pubmed
The translation initiation factor 4E (eIF4E) has been implicated in naturally occurring resistance to Potato virus Y (PVY) determined by the pvr2 locus in pepper (Capsicum annuum)...
Schaad M, Anderberg R, Carrington J. Strain-specific interaction of the tobacco etch virus NIa protein with the translation initiation factor eIF4E in the yeast two-hybrid system. Virology. 2000;273:300-6 pubmed
..Ten proteins that interacted with NIa were recovered, with translation initiation factor eIF4E being by far the most common protein identified. Interaction of eIF4E with NIa was shown to be TEV strain-specific...
Mazier M, Flamain F, Nicola M, Sarnette V, Caranta C. Knock-down of both eIF4E1 and eIF4E2 genes confers broad-spectrum resistance against potyviruses in tomato. PLoS ONE. 2011;6:e29595 pubmed publisher
..eIF4E belongs to a small multigenic family and three genes, eIF4E1, eIF4E2 and eIF(iso)4E, have been identified in tomato...
Gauffier C, Lebaron C, Moretti A, Constant C, Moquet F, Bonnet G, et al
. A TILLING approach to generate broad-spectrum resistance to potyviruses in tomato is hampered by eIF4E gene redundancy. Plant J. 2016;85:717-29 pubmed publisher
..For resistance based on translation initiation factor eIF4E1, we confirm that the natural allele Sh-eIF4E1(PI24)-pot1, isolated from the wild tomato species Solanum ..
Lebaron C, Rosado A, Sauvage C, Gauffier C, German Retana S, Moury B, et al
. A new eIF4E1 allele characterized by RNAseq data mining is associated with resistance to potato virus Y in tomato albeit with a low durability. J Gen Virol. 2016;97:3063-3072 pubmed publisher
..RNAseq data to investigate polymorphisms among the four tomato genes encoding translation initiation factors [eIF4E1 and eIF4E2, eIFiso4E and the related gene new cap-binding protein(nCBP)] to look for new potential resistance ..