Gene Symbol: TBEVgp1
Description: polyprotein
Species: Tick-borne encephalitis virus

Top Publications

  1. Lorenz I, Allison S, Heinz F, Helenius A. Folding and dimerization of tick-borne encephalitis virus envelope proteins prM and E in the endoplasmic reticulum. J Virol. 2002;76:5480-91 pubmed
  2. Stadler K, Allison S, Schalich J, Heinz F. Proteolytic activation of tick-borne encephalitis virus by furin. J Virol. 1997;71:8475-81 pubmed
    ..In vivo, prM cleavage was blocked by a furin inhibitor, and infection of the furin-deficient cell line LoVo yielded only immature virions, suggesting that furin is essential for cleavage activation of flaviviruses. ..
  3. Schrauf S, Kurz M, Taucher C, Mandl C, Skern T. Generation and genetic stability of tick-borne encephalitis virus mutants dependent on processing by the foot-and-mouth disease virus 3C protease. J Gen Virol. 2012;93:504-515 pubmed publisher
    ..These findings suggest a role of the positive charge of the C terminus of protein C for budding of the nucleocapsid and further support the notion that TBEV protein C is a multifunctional protein. ..
  4. Morozova O, Safronov I, Bahvalova V, Dobrikov M. Affinity labelling of the tick-borne encephalitis virus RNA replicase proteins by 4-N-exo-base-substituted photoreactive CTP analogs. Bioorg Med Chem Lett. 1998;8:787-92 pubmed
    ..Two flavivirus proteins NS5 and NS3 are shown to be labelled after RNA synthesis in the presence of the analogs, irradiation by UV-light (313 nm) and subsequent [alpha-32P]NTP incorporation. ..
  5. Pangerl K, Heinz F, Stiasny K. Mutational analysis of the zippering reaction during flavivirus membrane fusion. J Virol. 2011;85:8495-501 pubmed publisher
  6. Pressman E. Heterocomplexes of tick-borne encephalitis structural and non-structural proteins. FEBS Lett. 1993;333:268-70 pubmed
    ..Also, the trimer E-NS1-NS3 can be isolated. It is proposed that this trimer is the viral replicative complex. ..
  7. Pugachev K, Nomokonova N, Dobrikova EYu -, Wolf Y. Site-directed mutagenesis of the tick-borne encephalitis virus NS3 gene reveals the putative serine protease domain of the NS3 protein. FEBS Lett. 1993;328:115-8 pubmed
  8. Heinz F, Allison S, Stiasny K, Schalich J, Holzmann H, Mandl C, et al. Recombinant and virion-derived soluble and particulate immunogens for vaccination against tick-borne encephalitis. Vaccine. 1995;13:1636-42 pubmed
  9. Wallner G, Mandl C, Kunz C, Heinz F. The flavivirus 3'-noncoding region: extensive size heterogeneity independent of evolutionary relationships among strains of tick-borne encephalitis virus. Virology. 1995;213:169-78 pubmed publisher

More Information


  1. Lorenz I, Kartenbeck J, Mezzacasa A, Allison S, Heinz F, Helenius A. Intracellular assembly and secretion of recombinant subviral particles from tick-borne encephalitis virus. J Virol. 2003;77:4370-82 pubmed
    ..Moreover, the carbohydrate side chain of E is involved in at least one assembly or transport step...
  2. Mandl C, Heinz F, St ckl E, Kunz C. Genome sequence of tick-borne encephalitis virus (Western subtype) and comparative analysis of nonstructural proteins with other flaviviruses. Virology. 1989;173:291-301 pubmed
    ..Other characteristics, such as the potential N-glycosylation sites of protein NS1 and a potential proteolytic cleavage site within protein NS4B, are conserved within the mosquito-borne group, but differ in the TBE virus sequence...
  3. R zek D, Gritsun T, Forrester N, Gould E, Kopeck J, Golovchenko M, et al. Mutations in the NS2B and NS3 genes affect mouse neuroinvasiveness of a Western European field strain of tick-borne encephalitis virus. Virology. 2008;374:249-55 pubmed publisher
    ..The significance of these observations is discussed...
  4. Allison S, Schalich J, Stiasny K, Mandl C, Kunz C, Heinz F. Oligomeric rearrangement of tick-borne encephalitis virus envelope proteins induced by an acidic pH. J Virol. 1995;69:695-700 pubmed
    ..This is consistent with a protective role of protein prM for protein E during intracellular transport of immature virions through acidic compartments of the trans-Golgi network...
  5. Allison S, Stadler K, Mandl C, Kunz C, Heinz F. Synthesis and secretion of recombinant tick-borne encephalitis virus protein E in soluble and particulate form. J Virol. 1995;69:5816-20 pubmed
  6. Khoretonenko M, Vorovitch M, Zakharova L, Pashvykina G, Ovsyannikova N, Stephenson J, et al. Vaccinia virus recombinant expressing gene of tick-borne encephalitis virus non-structural NS1 protein elicits protective activity in mice. Immunol Lett. 2003;90:161-3 pubmed
    ..The recombinant expressed native dimeric form of the NS1 protein in infected cells and protected mice against lethal infection with TBEV...
  7. Werme K, Wigerius M, Johansson M. Tick-borne encephalitis virus NS5 associates with membrane protein scribble and impairs interferon-stimulated JAK-STAT signalling. Cell Microbiol. 2008;10:696-712 pubmed publisher
    ..These results define the TBEV NS5 protein in concert with hScrib as an antagonist of the IFN response, by demonstrating a correlation between the association and JAK-STAT interference...
  8. Panayiotou C, Lindqvist R, Kurhade C, Vonderstein K, Pasto J, Edlund K, et al. Viperin Restricts Zika Virus and Tick-Borne Encephalitis Virus Replication by Targeting NS3 for Proteasomal Degradation. J Virol. 2018;92: pubmed publisher
    ..Taking the results together, our work shows important similarities and differences among the members of the genus Flavivirus and could lead to the possibility of therapeutic intervention. ..
  9. Orlinger K, Hoenninger V, Kofler R, Mandl C. Construction and mutagenesis of an artificial bicistronic tick-borne encephalitis virus genome reveals an essential function of the second transmembrane region of protein e in flavivirus assembly. J Virol. 2006;80:12197-208 pubmed publisher
    ..Deletion analysis and replacement of the entire TBEV E-TM2 region with its counterpart from another flavivirus revealed that this element, apart from its role as a signal sequence, is important for virion formation...
  10. Fritz R, Blazevic J, Taucher C, Pangerl K, Heinz F, Stiasny K. The unique transmembrane hairpin of flavivirus fusion protein E is essential for membrane fusion. J Virol. 2011;85:4377-85 pubmed publisher
    ..Our data provide evidence for both intratrimer and intertrimer interactions mediated by the TMDs of E and thus extend the existing models of flavivirus membrane fusion...
  11. Yoshii K, Igarashi M, Ichii O, Yokozawa K, Ito K, Kariwa H, et al. A conserved region in the prM protein is a critical determinant in the assembly of flavivirus particles. J Gen Virol. 2012;93:27-38 pubmed publisher
    ..These results are the first demonstration that the conserved region in the prM protein is a molecular determinant for the flavivirus assembly process...
  12. Kurz M, Stefan N, Zhu J, Skern T. NS2B/3 proteolysis at the C-prM junction of the tick-borne encephalitis virus polyprotein is highly membrane dependent. Virus Res. 2012;168:48-55 pubmed publisher
  13. Yoshii K, Sunden Y, Yokozawa K, Igarashi M, Kariwa H, Holbrook M, et al. A critical determinant of neurological disease associated with highly pathogenic tick-borne flavivirus in mice. J Virol. 2014;88:5406-20 pubmed publisher
    ..These findings provide new insight into the molecular mechanisms of tick-borne flavivirus pathogenesis. ..
  14. Morozova O, Kolpashchikov D, Ivanova T, Godovikova T. Synthesis of new photocross-linking 5-C-base-substituted UTP analogs and their application in highly selective affinity labelling of the tick-borne encephalitis virus RNA replicase proteins. Nucleosides Nucleotides. 1999;18:1513-4 pubmed
    ..Two flavivirus proteins NS5 and NS3 are shown to be labelled after RNA synthesis in the presence of the analogs, irradiation (lambda > 300 nm) and subsequent [alpha-32P]NTP incorporation. ..
  15. Stiasny K, Allison S, Marchler Bauer A, Kunz C, Heinz F. Structural requirements for low-pH-induced rearrangements in the envelope glycoprotein of tick-borne encephalitis virus. J Virol. 1996;70:8142-7 pubmed
    ..This region contains potential amphipathic alpha-helical and conserved structural elements whose interactions may contribute to the rearrangements which initiate the fusion process...
  16. Mandl C, Heinz F, Kunz C. Sequence of the structural proteins of tick-borne encephalitis virus (western subtype) and comparative analysis with other flaviviruses. Virology. 1988;166:197-205 pubmed