Gene Symbol: TA_RS03155
Description: proteasome subunit beta
Species: Thermoplasma acidophilum DSM 1728
- Steinbacher S, Seckler R, Miller S, Steipe B, Huber R, Reinemer P. Crystal structure of P22 tailspike protein: interdigitated subunits in a thermostable trimer. Science. 1994;265:383-6 pubmed..The interdigitation of the polypeptide chains at the carboxyl termini is important to protrimer formation in the folding pathway and to thermostability of the mature protein...
- Kisselev A, Akopian T, Goldberg A. Range of sizes of peptide products generated during degradation of different proteins by archaeal proteasomes. J Biol Chem. 1998;273:1982-9 pubmed
- F rster A, Masters E, Whitby F, Robinson H, Hill C. The 1.9 A structure of a proteasome-11S activator complex and implications for proteasome-PAN/PA700 interactions. Mol Cell. 2005;18:589-99 pubmed publisher..Surprisingly, biochemical observations implicate an equivalent interaction for the unrelated ATP-dependent activators PAN and PA700...
- Pühler G, Weinkauf S, Bachmann L, Muller S, Engel A, Hegerl R, et al. Subunit stoichiometry and three-dimensional arrangement in proteasomes from Thermoplasma acidophilum. EMBO J. 1992;11:1607-16 pubmed..In contrast to some previous reports we have not been able to find stoichiometric amounts of RNA associated with highly purified proteolytically active proteasome preparations. ..
- Seemuller E, Lupas A, Baumeister W. Autocatalytic processing of the 20S proteasome. Nature. 1996;382:468-71 pubmed publisher..Although serine is an acceptable active-site nucleophile for proteolysis, and cysteine for processing, only threonine is fully functional in both. This explains why threonine is universally conserved in active proteasome subunits...
- Akopian T, Kisselev A, Goldberg A. Processive degradation of proteins and other catalytic properties of the proteasome from Thermoplasma acidophilum. J Biol Chem. 1997;272:1791-8 pubmed..Thus, processivity is an inherent feature of the 20 S proteasome, not requiring all active sites or ATP hydrolysis...