Gene Symbol: ZWILLE
Description: Stabilizer of iron transporter SufD / Polynucleotidyl transferase
Alias: ARGONAUTE 10, ARGONAUTE PROTEIN 10, MQD19.17, MQD19_17, PINHEAD, PNH, ZLL, ZWILLE, Stabilizer of iron transporter SufD / Polynucleotidyl transferase
Species: thale cress

Top Publications

  1. Mallory A, Hinze A, Tucker M, Bouche N, Gasciolli V, Elmayan T, et al. Redundant and specific roles of the ARGONAUTE proteins AGO1 and ZLL in development and small RNA-directed gene silencing. PLoS Genet. 2009;5:e1000646 pubmed publisher
    The Arabidopsis ARGONAUTE1 (AGO1) and ZWILLE/PINHEAD/AGO10 (ZLL) proteins act in the miRNA and siRNA pathways and are essential for multiple processes in development...
  2. Moussian B, Haecker A, Laux T. ZWILLE buffers meristem stability in Arabidopsis thaliana. Dev Genes Evol. 2003;213:534-40 pubmed
    ..Meristem plasticity requires the ZWILLE (ZLL) gene...
  3. Liu Q, Yao X, Pi L, Wang H, Cui X, Huang H. The ARGONAUTE10 gene modulates shoot apical meristem maintenance and establishment of leaf polarity by repressing miR165/166 in Arabidopsis. Plant J. 2009;58:27-40 pubmed publisher
    ..Previous studies revealed that the Arabidopsis ARGONAUTE10 [AGO10, also called PINHEAD (PNH) or ZWILLE (ZLL)] gene is one of the critical SAM regulators, but the mechanism by which AGO10 modulates the ..
  4. Tucker M, Hinze A, Tucker E, Takada S, Jurgens G, Laux T. Vascular signalling mediated by ZWILLE potentiates WUSCHEL function during shoot meristem stem cell development in the Arabidopsis embryo. Development. 2008;135:2839-43 pubmed publisher
    ..Here we show that, in the absence of functional ZWILLE (ZLL), which is a member of the ARGONAUTE (AGO) family, stem cell-specific expression of the signal peptide gene ..
  5. Zhu H, Hu F, Wang R, Zhou X, Sze S, Liou L, et al. Arabidopsis Argonaute10 specifically sequesters miR166/165 to regulate shoot apical meristem development. Cell. 2011;145:242-56 pubmed publisher
    ..We propose that AGO10 functions as a decoy for miR166/165 to maintain the SAM, preventing their incorporation into AGO1 complexes and the subsequent repression of HD-ZIP III gene expression. ..
  6. Tucker M, Roodbarkelari F, Truernit E, Adamski N, Hinze A, Lohmüller B, et al. Accession-specific modifiers act with ZWILLE/ARGONAUTE10 to maintain shoot meristem stem cells during embryogenesis in Arabidopsis. BMC Genomics. 2013;14:809 pubmed publisher
    ..In Arabidopsis thaliana, the ZWILLE/PINHEAD/AGO10 (ZLL) gene encodes a member of the ARGONAUTE (AGO) protein family and is required to maintain shoot ..
  7. Roodbarkelari F, Du F, Truernit E, Laux T. ZLL/AGO10 maintains shoot meristem stem cells during Arabidopsis embryogenesis by down-regulating ARF2-mediated auxin response. BMC Biol. 2015;13:74 pubmed publisher
    ..Loss-of-function mutants of the ZWILLE/ARGONAUTE10/PINHEAD (ZLL/AGO10/PNH) gene terminate shoot meristem stem cells late in embryogenesis and can form a leaf or a leaf-like ..
  8. Yu Y, Ji L, Le B, Zhai J, Chen J, Luscher E, et al. ARGONAUTE10 promotes the degradation of miR165/6 through the SDN1 and SDN2 exonucleases in Arabidopsis. PLoS Biol. 2017;15:e2001272 pubmed publisher
    ..This work, together with previous studies on AGO10, suggests that spatially regulated miRNA degradation underlies stem cell maintenance in plants. ..
  9. Ji L, Liu X, Yan J, Wang W, Yumul R, Kim Y, et al. ARGONAUTE10 and ARGONAUTE1 regulate the termination of floral stem cells through two microRNAs in Arabidopsis. PLoS Genet. 2011;7:e1001358 pubmed publisher

More Information


  1. Garcia Ruiz H, Carbonell A, Hoyer J, Fahlgren N, Gilbert K, Takeda A, et al. Roles and programming of Arabidopsis ARGONAUTE proteins during Turnip mosaic virus infection. PLoS Pathog. 2015;11:e1004755 pubmed publisher
    ..These findings indicate that distinct AGO proteins function as antiviral modules, and provide a molecular explanation for the silencing suppressor activity of HC-Pro. ..
  2. Brosseau C, Moffett P. Functional and Genetic Analysis Identify a Role for Arabidopsis ARGONAUTE5 in Antiviral RNA Silencing. Plant Cell. 2015;27:1742-54 pubmed publisher
    ..In agreement with functional assays, we show that Potexvirus infection induces AGO5 expression and that both AGO2 and AGO5 are required for full restriction of PVX infection in systemic tissues of Arabidopsis. ..
  3. Ding L, Yan S, Jiang L, Zhao W, Ning K, Zhao J, et al. HANABA TARANU (HAN) Bridges Meristem and Organ Primordia Boundaries through PINHEAD, JAGGED, BLADE-ON-PETIOLE2 and CYTOKININ OXIDASE 3 during Flower Development in Arabidopsis. PLoS Genet. 2015;11:e1005479 pubmed publisher
    ..interactions between the boundary gene HANABA TARANU (HAN) and two meristem regulators BREVIPEDICELLUS (BP) and PINHEAD (PNH), and three primordia-specific genes PETAL LOSS (PTL), JAGGED (JAG) and BLADE-ON-PETIOLE (BOP) during flower ..
  4. Zhou Y, Honda M, Zhu H, Zhang Z, Guo X, Li T, et al. Spatiotemporal sequestration of miR165/166 by Arabidopsis Argonaute10 promotes shoot apical meristem maintenance. Cell Rep. 2015;10:1819-27 pubmed
    ..Thus, this study provides insight into how the spatiotemporal regulation of AGO10-miR165/166 activity affects SAM development. ..
  5. Ma W, Wu F, Sheng P, Wang X, Zhang Z, Zhou K, et al. The LBD12-1 Transcription Factor Suppresses Apical Meristem Size by Repressing Argonaute 10 Expression. Plant Physiol. 2017;173:801-811 pubmed publisher
    ..Our findings provide novel insights into the regulatory mechanism of AGO10 by which SAM size is controlled under stress conditions. ..
  6. Zhang Z, Hu F, Sung M, Shu C, Castillo González C, Koiwa H, et al. RISC-interacting clearing 3'- 5' exoribonucleases (RICEs) degrade uridylated cleavage fragments to maintain functional RISC in Arabidopsis thaliana. elife. 2017;6: pubmed publisher
    ..We conclude that RICEs act to degrade uridylated 5' products of AGO cleavage to maintain functional RISC. Our study also suggests a possible link between decay of cleaved target mRNAs and miRNA stability in RISC. ..
  7. Nishimura A, Ito M, Kamiya N, Sato Y, Matsuoka M. OsPNH1 regulates leaf development and maintenance of the shoot apical meristem in rice. Plant J. 2002;30:189-201 pubmed
    The Arabidopsis PINHEAD/ZWILLE (PNH/ZLL) gene is thought to play an important role in the formation of the shoot apical meristem (SAM) and in leaf adaxial cell specification...