Gene Symbol: ZAT
Description: zinc transporter
Alias: A. THALIANA CATION DIFFUSION FACILITATOR 1, ATCDF1, ATMTP1, F19D11.8, MTP1, OVERLY ZINC SENSITIVE 1, OZS1, ZAT1, ZINC TRANSPORTER OF ARABIDOPSIS THALIANA 1, ZINC TRANSPORTER ZAT, metal tolerance protein 1, zinc transporter of Arabidopsis thaliana, zinc transporter
Species: thale cress
Desbrosses Fonrouge A, Voigt K, Schroder A, Arrivault S, Thomine S, Krämer U. Arabidopsis thaliana MTP1 is a Zn transporter in the vacuolar membrane which mediates Zn detoxification and drives leaf Zn accumulation. FEBS Lett. 2005;579:4165-74 pubmed
The Arabidopsis thaliana metal tolerance protein 1 (MTP1) of the cation diffusion facilitator family of membrane transport proteins can mediate the detoxification of Zn in Arabidopsis and yeast...
van der Zaal B, Neuteboom L, Pinas J, Chardonnens A, Schat H, Verkleij J, et al
. Overexpression of a novel Arabidopsis gene related to putative zinc-transporter genes from animals can lead to enhanced zinc resistance and accumulation. Plant Physiol. 1999;119:1047-55 pubmed
..The protein encoded by the ZAT (Zn transporter of Arabidopsis thaliana) gene has 398 amino acid residues and is predicted to have six membrane-..
Kawachi M, Kobae Y, Mimura T, Maeshima M. Deletion of a histidine-rich loop of AtMTP1, a vacuolar Zn(2+)/H(+) antiporter of Arabidopsis thaliana, stimulates the transport activity. J Biol Chem. 2008;283:8374-83 pubmed publisher
Arabidopsis thaliana AtMTP1 belongs to the cation diffusion facilitator family and is localized on the vacuolar membrane...
Bloss T, Clemens S, Nies D. Characterization of the ZAT1p zinc transporter from Arabidopsis thaliana in microbial model organisms and reconstituted proteoliposomes. Planta. 2002;214:783-91 pubmed
The ZAT1p zinc transporter from Arabidopsis thaliana (L.) Heynh. is a member of the cation diffusion facilitator (CDF) protein family. When heterologously expressed in Escherichia coli, ZAT1p bound zinc in a metal blot...
Kobae Y, Uemura T, Sato M, Ohnishi M, Mimura T, Nakagawa T, et al
. Zinc transporter of Arabidopsis thaliana AtMTP1 is localized to vacuolar membranes and implicated in zinc homeostasis. Plant Cell Physiol. 2004;45:1749-58 pubmed
..We investigated the subcellular localization of Arabidopsis thaliana AtMTP1, a member of the CDF family, and its physiological role in the tolerance to Zn using MTP1-deficient mutant plants...
Krämer U. MTP1 mops up excess zinc in Arabidopsis cells. Trends Plant Sci. 2005;10:313-5 pubmed
..In a recent publication, Yoshihiro Kobae and colleagues show that AtMTP1 localizes to the vacuolar membrane in Arabidopsis roots and suspension-cultured cells...
Shahzad Z, Gosti F, Frérot H, Lacombe E, Roosens N, Saumitou Laprade P, et al
. The five AhMTP1 zinc transporters undergo different evolutionary fates towards adaptive evolution to zinc tolerance in Arabidopsis halleri. PLoS Genet. 2010;6:e1000911 pubmed publisher
..b>Metal Tolerance Protein 1 (MTP1) is one of these genes...
Kawachi M, Kobae Y, Mori H, Tomioka R, Lee Y, Maeshima M. A mutant strain Arabidopsis thaliana that lacks vacuolar membrane zinc transporter MTP1 revealed the latent tolerance to excessive zinc. Plant Cell Physiol. 2009;50:1156-70 pubmed publisher
A mutant line of Arabidopsis thaliana that lacks a vacuolar membrane Zn(2+)/H(+) antiporter MTP1 is sensitive to zinc...
Kawachi M, Kobae Y, Kogawa S, Mimura T, Krämer U, Maeshima M. Amino acid screening based on structural modeling identifies critical residues for the function, ion selectivity and structure of Arabidopsis MTP1. FEBS J. 2012;279:2339-56 pubmed publisher
..Here we present a structure-function analysis of AtMTP1-mediated transport and its remarkable Zn(2+) selectivity by functional complementation tests of more than 50 ..