Gene Symbol: VIP1
Description: VIRE2-interacting protein 1
Alias: AtVIP1, F2J6.6, F2J6_6, SUE3, VIRE2-INTERACTING PROTEIN, VIRE2-interacting protein 1, sulphate utilization efficiency 3, VIRE2-interacting protein 1
Species: thale cress

Top Publications

  1. Lacroix B, Citovsky V. Characterization of VIP1 activity as a transcriptional regulator in vitro and in planta. Sci Rep. 2013;3:2440 pubmed publisher
    VIP1 (VirE2 interacting protein 1), initially discovered as a host protein involved in Agrobacterium-plant cell DNA transfer, is a transcription factor of the basic leucine-zipper (bZIP) domain family that regulates several defence-..
  2. Li J, Krichevsky A, Vaidya M, Tzfira T, Citovsky V. Uncoupling of the functions of the Arabidopsis VIP1 protein in transient and stable plant genetic transformation by Agrobacterium. Proc Natl Acad Sci U S A. 2005;102:5733-8 pubmed
    ..One such cellular factor is VIP1, an Arabidopsis protein proposed to interact with and facilitate import of the bacterial DNA-protein transport (T) ..
  3. Tzfira T, Vaidya M, Citovsky V. Increasing plant susceptibility to Agrobacterium infection by overexpression of the Arabidopsis nuclear protein VIP1. Proc Natl Acad Sci U S A. 2002;99:10435-40 pubmed
    ..Here, we examined the effect of overexpression in tobacco plants of an Arabidopsis gene, VIP1, which encodes a recently discovered cellular protein required for Agrobacterium infection...
  4. Tzfira T, Vaidya M, Citovsky V. Involvement of targeted proteolysis in plant genetic transformation by Agrobacterium. Nature. 2004;431:87-92 pubmed publisher
    ..3) and VirE2 (ref. 4) and their host cell interactors AtKAP-alpha and VIP1 (ref. 6), whereas its integration is mediated mainly by host cell proteins...
  5. Djamei A, Pitzschke A, Nakagami H, Rajh I, Hirt H. Trojan horse strategy in Agrobacterium transformation: abusing MAPK defense signaling. Science. 2007;318:453-6 pubmed
    ..virulence protein VirE2 mediates this process by binding to the nuclear import machinery via the host cell factor VIP1, whose role in plants has been so far unknown...
  6. Tzfira T, Vaidya M, Citovsky V. VIP1, an Arabidopsis protein that interacts with Agrobacterium VirE2, is involved in VirE2 nuclear import and Agrobacterium infectivity. EMBO J. 2001;20:3596-607 pubmed
    ..The identified plant protein, designated VIP1, specifically bound VirE2 and allowed its nuclear import in non-plant systems...
  7. Zaltsman A, Krichevsky A, Loyter A, Citovsky V. Agrobacterium induces expression of a host F-box protein required for tumorigenicity. Cell Host Microbe. 2010;7:197-209 pubmed publisher
    ..genetic transformation by targeting for proteolysis proteins, the Agrobacterium protein VirE2 and the host protein VIP1, that coat the transferred DNA. However, some plant species do not require VirF for transformation...
  8. Pitzschke A, Djamei A, Teige M, Hirt H. VIP1 response elements mediate mitogen-activated protein kinase 3-induced stress gene expression. Proc Natl Acad Sci U S A. 2009;106:18414-9 pubmed publisher
    ..A key role of VirE2-interacting protein 1 (VIP1) in the nuclear import of T-DNA during Agrobacterium-mediated plant transformation has been unravelled and VIP1 was ..
  9. Wu Y, Zhao Q, Gao L, Yu X, Fang P, Oliver D, et al. Isolation and characterization of low-sulphur-tolerant mutants of Arabidopsis. J Exp Bot. 2010;61:3407-22 pubmed publisher
    ..Here the isolation and characterization of two low-sulphur-tolerant mutants, sue3 and sue4 are reported using a high-throughput genetic screen where a 'sulphur-free' solid medium was devised to ..

More Information


  1. Tsugama D, Liu S, Takano T. A bZIP protein, VIP1, is a regulator of osmosensory signaling in Arabidopsis. Plant Physiol. 2012;159:144-55 pubmed publisher
    ..The factors that regulate CYP707A1/3 are not well characterized. We expressed a bZIP protein, VIP1, as a green fluorescent protein fusion protein in Arabidopsis and found that the nuclear localization of VIP1 was ..
  2. Anand A, Krichevsky A, Schornack S, Lahaye T, Tzfira T, Tang Y, et al. Arabidopsis VIRE2 INTERACTING PROTEIN2 is required for Agrobacterium T-DNA integration in plants. Plant Cell. 2007;19:1695-708 pubmed
    ..Furthermore, we provide evidence supporting VIP2 interaction with VIP1, a basic domain/leucine zipper motif-containing protein required for nuclear import and integration of T-DNA...
  3. Avivi Y, Morad V, Ben Meir H, Zhao J, Kashkush K, Tzfira T, et al. Reorganization of specific chromosomal domains and activation of silent genes in plant cells acquiring pluripotentiality. Dev Dyn. 2004;230:12-22 pubmed
    ..Within the pericentromeric subdomain, VIP1, a gene encoding a b-Zip nuclear protein required for Agrobacterium infectivity, was transcriptionally activated...
  4. Shen H, Cao K, Wang X. A conserved proline residue in the leucine zipper region of AtbZIP34 and AtbZIP61 in Arabidopsis thaliana interferes with the formation of homodimer. Biochem Biophys Res Commun. 2007;362:425-30 pubmed
    ..So we speculate that AtbZIP34 and AtbZIP61 may participate in plant development via interacting with other group bZIP transcription factors. ..
  5. Lacroix B, Vaidya M, Tzfira T, Citovsky V. The VirE3 protein of Agrobacterium mimics a host cell function required for plant genetic transformation. EMBO J. 2005;24:428-37 pubmed
    ..The VirE2 nuclear import in turn is mediated by a plant protein, VIP1. Our data indicate that VirE3 can mimic this VIP1 function, acting as an 'adapter' molecule between VirE2 and ..
  6. Tsugama D, Liu S, Takano T. The bZIP Protein VIP1 Is Involved in Touch Responses in Arabidopsis Roots. Plant Physiol. 2016;171:1355-65 pubmed publisher
    b>VIP1 is a bZIP transcription factor in Arabidopsis (Arabidopsis thaliana). VIP1 transiently accumulates in the nucleus when cells are exposed to hypoosmotic conditions, but its physiological relevance is unclear...
  7. Takeo K, Ito T. Subcellular localization of VIP1 is regulated by phosphorylation and 14-3-3 proteins. FEBS Lett. 2017;591:1972-1981 pubmed publisher
    Arabidopsis basic leucine zipper transcription factor VIRE2-interacting protein 1 (VIP1) changes its localization from the cytosol to the nucleus when cells are subjected to mechanical or hypo-osmotic stress, although the mechanism of ..
  8. Tsugama D, Liu S, Takano T. A bZIP protein, VIP1, interacts with Arabidopsis heterotrimeric G protein ? subunit, AGB1. Plant Physiol Biochem. 2013;71:240-6 pubmed publisher
    ..By a yeast two-hybrid screen, we identified a bZIP protein, VIP1, as an Arabidopsis thaliana G? (AGB1)-interacting partner...
  9. Tsugama D, Liu S, Takano T. Metal-binding ability of VIP1: a bZIP protein in Arabidopsis thaliana. Protein J. 2013;32:526-32 pubmed publisher
    VirE2-interacting protein 1 (VIP1) is an Arabidopsis thaliana bZIP transcription factor which regulates pathogen responses and rehydration responses...
  10. Maes M, Amit E, Danieli T, Lebendiker M, Loyter A, Friedler A. The disordered region of Arabidopsis VIP1 binds the Agrobacterium VirE2 protein outside its DNA-binding site. Protein Eng Des Sel. 2014;27:439-46 pubmed publisher
    ..Within the transfected cells, VirE2 interacts with the plant VIP1 leading to nuclear transport of the T-DNA complex...
  11. Tsugama D, Liu S, Takano T. VIP1 is very important/interesting protein 1 regulating touch responses of Arabidopsis. Plant Signal Behav. 2016;11:e1187358 pubmed publisher
    b>VIP1 (VIRE2-INTERACTING PROTEIN 1) is a bZIP transcription factor in Arabidopsis thaliana. VIP1 and its close homologs (i.e...
  12. Shi Y, Lee L, Gelvin S. Is VIP1 important for Agrobacterium-mediated transformation?. Plant J. 2014;79:848-60 pubmed publisher
    ..This process requires both Agrobacterium and host proteins. VirE2 interacting protein 1 (VIP1), an Arabidopsis bZIP protein, has been suggested to mediate transformation through interaction ..
  13. Tsugama D, Liu S, Takano T. Analysis of functions of VIP1 and its close homologs in osmosensory responses of Arabidopsis thaliana. PLoS ONE. 2014;9:e103930 pubmed publisher
    b>VIP1 is a bZIP protein in Arabidopsis thaliana...