Gene Symbol: VIM1
Description: Zinc finger (C3HC4-type RING finger) family protein
Alias: F12K22.14, F12K22_14, ORTH2, ORTHRUS 2, VARIANT IN METHYLATION 1, Zinc finger (C3HC4-type RING finger) family protein
Species: thale cress

Top Publications

  1. Liu S, Yu Y, Ruan Y, Meyer D, Wolff M, Xu L, et al. Plant SET- and RING-associated domain proteins in heterochromatinization. Plant J. 2007;52:914-26 pubmed
    ..In the yeast two-hybrid assay, NtSET1 binds the DNA methylcytosine-binding protein VARIANT IN METHYLATION1 (VIM1), which contains conserved PHD, SRA and RING domains...
  2. Johnson L, Bostick M, Zhang X, Kraft E, Henderson I, Callis J, et al. The SRA methyl-cytosine-binding domain links DNA and histone methylation. Curr Biol. 2007;17:379-84 pubmed
    ..Hence, unlike the methyl-binding domain (MBD), which binds only methylated-CpG sequences, the SRA domain is a versatile new methyl-DNA-binding motif. ..
  3. Woo H, Pontes O, Pikaard C, Richards E. VIM1, a methylcytosine-binding protein required for centromeric heterochromatinization. Genes Dev. 2007;21:267-77 pubmed
    ..We identified vim1 (VARIANT IN METHYLATION 1), an Arabidopsis mutation causing cytosine hypomethylation and decondensation of centromeres in ..
  4. Kraft E, Bostick M, Jacobsen S, Callis J. ORTH/VIM proteins that regulate DNA methylation are functional ubiquitin E3 ligases. Plant J. 2008;56:704-15 pubmed publisher
    ..cDNAs for ORTH1, ORTH2, ORTH5 and ORTHlike-1 were isolated, and when expressed as glutathione-S-transferase (GST) fusion proteins, were ..
  5. Yao Q, Song C, He C, Kumaran D, Dunn J. Heterologous expression and purification of Arabidopsis thaliana VIM1 protein: in vitro evidence for its inability to recognize hydroxymethylcytosine, a rare base in Arabidopsis DNA. Protein Expr Purif. 2012;83:104-11 pubmed publisher
    ..look for this base in the DNA of Arabidopsis thaliana (thale cress), and to ask how well the Arabidopsis Variant in Methylation 1 (VIM1) protein, an essential factor in maintaining 5-cytosine methylation (5mC) homeostasis and ..
  6. Shook M, Richards E. VIM proteins regulate transcription exclusively through the MET1 cytosine methylation pathway. Epigenetics. 2014;9:980-6 pubmed publisher
    ..b>VIM1 acts as a cofactor of DNA methyltransferase 1 (MET1), although the mechanism for this co-regulation remains unclear...
  7. Woo H, Dittmer T, Richards E. Three SRA-domain methylcytosine-binding proteins cooperate to maintain global CpG methylation and epigenetic silencing in Arabidopsis. PLoS Genet. 2008;4:e1000156 pubmed publisher
    ..b>VARIANT IN METHYLATION 1 (VIM1) encodes an SRA (SET- and RING-associated) domain methylcytosine-binding protein in Arabidopsis ..