Gene Symbol: VIM1
Description: Zinc finger (C3HC4-type RING finger) family protein
Alias: F12K22.14, F12K22_14, ORTH2, ORTHRUS 2, VARIANT IN METHYLATION 1, Zinc finger (C3HC4-type RING finger) family protein
Species: thale cress
Liu S, Yu Y, Ruan Y, Meyer D, Wolff M, Xu L, et al
. Plant SET- and RING-associated domain proteins in heterochromatinization. Plant J. 2007;52:914-26 pubmed
..In the yeast two-hybrid assay, NtSET1 binds the DNA methylcytosine-binding protein VARIANT IN METHYLATION1 (VIM1), which contains conserved PHD, SRA and RING domains...
Johnson L, Bostick M, Zhang X, Kraft E, Henderson I, Callis J, et al
. The SRA methyl-cytosine-binding domain links DNA and histone methylation. Curr Biol. 2007;17:379-84 pubmed
..Hence, unlike the methyl-binding domain (MBD), which binds only methylated-CpG sequences, the SRA domain is a versatile new methyl-DNA-binding motif. ..
Woo H, Pontes O, Pikaard C, Richards E. VIM1, a methylcytosine-binding protein required for centromeric heterochromatinization. Genes Dev. 2007;21:267-77 pubmed
..We identified vim1 (VARIANT IN METHYLATION 1), an Arabidopsis mutation causing cytosine hypomethylation and decondensation of centromeres in ..
Kraft E, Bostick M, Jacobsen S, Callis J. ORTH/VIM proteins that regulate DNA methylation are functional ubiquitin E3 ligases. Plant J. 2008;56:704-15 pubmed publisher
..cDNAs for ORTH1, ORTH2, ORTH5 and ORTHlike-1 were isolated, and when expressed as glutathione-S-transferase (GST) fusion proteins, were ..
Yao Q, Song C, He C, Kumaran D, Dunn J. Heterologous expression and purification of Arabidopsis thaliana VIM1 protein: in vitro evidence for its inability to recognize hydroxymethylcytosine, a rare base in Arabidopsis DNA. Protein Expr Purif. 2012;83:104-11 pubmed publisher
..look for this base in the DNA of Arabidopsis thaliana (thale cress), and to ask how well the Arabidopsis Variant in Methylation 1 (VIM1) protein, an essential factor in maintaining 5-cytosine methylation (5mC) homeostasis and ..
Shook M, Richards E. VIM proteins regulate transcription exclusively through the MET1 cytosine methylation pathway. Epigenetics. 2014;9:980-6 pubmed publisher
..b>VIM1 acts as a cofactor of DNA methyltransferase 1 (MET1), although the mechanism for this co-regulation remains unclear...
Woo H, Dittmer T, Richards E. Three SRA-domain methylcytosine-binding proteins cooperate to maintain global CpG methylation and epigenetic silencing in Arabidopsis. PLoS Genet. 2008;4:e1000156 pubmed publisher
..b>VARIANT IN METHYLATION 1 (VIM1) encodes an SRA (SET- and RING-associated) domain methylcytosine-binding protein in Arabidopsis ..