UVR8

Summary

Gene Symbol: UVR8
Description: Regulator of chromosome condensation (RCC1) family protein
Alias: MGI19.7, MGI19_7, UVB-RESISTANCE 8, Regulator of chromosome condensation (RCC1) family protein
Species: thale cress
Products:     UVR8

Top Publications

  1. Kliebenstein D, Lim J, Landry L, Last R. Arabidopsis UVR8 regulates ultraviolet-B signal transduction and tolerance and contains sequence similarity to human regulator of chromatin condensation 1. Plant Physiol. 2002;130:234-43 pubmed
    ..This mutant, UV resistance locus 8-1 (uvr8-1), contains a single recessive mutation at the bottom of chromosome 5...
  2. Brown B, Cloix C, Jiang G, Kaiserli E, Herzyk P, Kliebenstein D, et al. A UV-B-specific signaling component orchestrates plant UV protection. Proc Natl Acad Sci U S A. 2005;102:18225-30 pubmed
    ..Here we report that Arabidopsis UV RESISTANCE LOCUS 8 (UVR8) is a UV-B-specific signaling component that orchestrates expression of a range of genes with vital UV-protective ..
  3. Kaiserli E, Jenkins G. UV-B promotes rapid nuclear translocation of the Arabidopsis UV-B specific signaling component UVR8 and activates its function in the nucleus. Plant Cell. 2007;19:2662-73 pubmed
    Arabidopsis thaliana UV RESISTANCE LOCUS8 (UVR8) is a UV-B-specific signaling component that binds to chromatin and regulates UV protection by orchestrating expression of a range of genes. Here, we studied how UV-B regulates UVR8...
  4. Brown B, Jenkins G. UV-B signaling pathways with different fluence-rate response profiles are distinguished in mature Arabidopsis leaf tissue by requirement for UVR8, HY5, and HYH. Plant Physiol. 2008;146:576-88 pubmed
    ..Arabidopsis (Arabidopsis thaliana) UV RESISTANCE LOCUS8 (UVR8) is a recently identified UV-B-specific signaling component that regulates UV-protective responses...
  5. Favory J, Stec A, Gruber H, Rizzini L, Oravecz A, Funk M, et al. Interaction of COP1 and UVR8 regulates UV-B-induced photomorphogenesis and stress acclimation in Arabidopsis. EMBO J. 2009;28:591-601 pubmed publisher
    ..The UV-B-specific UV RESPONSE LOCUS 8 (UVR8) and the multifunctional E3 ubiquitin ligase CONSTITUTIVELY PHOTOMORPHOGENIC 1 (COP1) are key regulators of the UV-..
  6. Heijde M, Ulm R. Reversion of the Arabidopsis UV-B photoreceptor UVR8 to the homodimeric ground state. Proc Natl Acad Sci U S A. 2013;110:1113-8 pubmed publisher
    Plants require the UV-B photoreceptor UV resistance locus 8 (UVR8) for acclimation and survival in sunlight...
  7. O Hara A, Jenkins G. In vivo function of tryptophans in the Arabidopsis UV-B photoreceptor UVR8. Plant Cell. 2012;24:3755-66 pubmed publisher
    Arabidopsis thaliana UV RESISTANCE LOCUS8 (UVR8) is a photoreceptor specifically for UV-B light that initiates photomorphogenic responses in plants...
  8. Feher B, Kozma Bognar L, Kevei E, Hajdu A, Binkert M, Davis S, et al. Functional interaction of the circadian clock and UV RESISTANCE LOCUS?8-controlled UV-B signaling pathways in Arabidopsis thaliana. Plant J. 2011;67:37-48 pubmed publisher
    ..We show that low-intensity UV-B radiation acts as entraining signal for the clock. UV RESISTANCE LOCUS?8 (UVR8) and CONSTITUTIVELY PHOTOMORPHOGENIC?1 (COP1) are required, but ELONGATED HYPOCOTYL?5 (HY5) and HY5 HOMOLOG (HYH) ..
  9. Cloix C, Jenkins G. Interaction of the Arabidopsis UV-B-specific signaling component UVR8 with chromatin. Mol Plant. 2008;1:118-28 pubmed publisher
    Arabidopsis UV RESISTANCE LOCUS8 (UVR8) is a UV-B-specific signaling component that regulates expression of a range of genes concerned with UV protection. Here, we investigate the interaction of UVR8 with chromatin...

More Information

Publications41

  1. Wu D, Hu Q, Yan Z, Chen W, Yan C, Huang X, et al. Structural basis of ultraviolet-B perception by UVR8. Nature. 2012;484:214-9 pubmed publisher
    The Arabidopsis thaliana protein UVR8 is a photoreceptor for ultraviolet-B. Upon ultraviolet-B irradiation, UVR8 undergoes an immediate switch from homodimer to monomer, which triggers a signalling pathway for ultraviolet protection...
  2. Heilmann M, Jenkins G. Rapid reversion from monomer to dimer regenerates the ultraviolet-B photoreceptor UV RESISTANCE LOCUS8 in intact Arabidopsis plants. Plant Physiol. 2013;161:547-55 pubmed publisher
    Arabidopsis (Arabidopsis thaliana) UV RESISTANCE LOCUS8 (UVR8) is a photoreceptor that specifically mediates photomorphogenic responses to ultraviolet (UV)-B in plants...
  3. Demkura P, Ballaré C. UVR8 mediates UV-B-induced Arabidopsis defense responses against Botrytis cinerea by controlling sinapate accumulation. Mol Plant. 2012;5:642-52 pubmed publisher
    ..resistance to the necrotrophic fungus Botrytis cinerea and that this effect is mediated by the photoreceptor UVR8. The UV-B effect on plant resistance was conserved in mutants impaired in jasmonate (JA) signaling (jar1-1 and P35S:..
  4. Rizzini L, Favory J, Cloix C, Faggionato D, O Hara A, Kaiserli E, et al. Perception of UV-B by the Arabidopsis UVR8 protein. Science. 2011;332:103-6 pubmed publisher
    ..Here we show that dimers of the UVR8 protein perceive UV-B, probably by a tryptophan-based mechanism...
  5. Christie J, Arvai A, Baxter K, Heilmann M, Pratt A, O Hara A, et al. Plant UVR8 photoreceptor senses UV-B by tryptophan-mediated disruption of cross-dimer salt bridges. Science. 2012;335:1492-6 pubmed publisher
    The recently identified plant photoreceptor UVR8 (UV RESISTANCE LOCUS 8) triggers regulatory changes in gene expression in response to ultraviolet-B (UV-B) light through an unknown mechanism...
  6. Heijde M, Binkert M, Yin R, Ares Orpel F, Rizzini L, Van De Slijke E, et al. Constitutively active UVR8 photoreceptor variant in Arabidopsis. Proc Natl Acad Sci U S A. 2013;110:20326-31 pubmed publisher
    Arabidopsis thaliana UV RESISTANCE LOCUS 8 (UVR8) is a UV-B photoreceptor that initiates photomorphogenic responses underlying acclimation and UV-B tolerance in plants...
  7. Cloix C, Kaiserli E, Heilmann M, Baxter K, Brown B, O Hara A, et al. C-terminal region of the UV-B photoreceptor UVR8 initiates signaling through interaction with the COP1 protein. Proc Natl Acad Sci U S A. 2012;109:16366-70 pubmed publisher
    UV-B light initiates photomorphogenic responses in plants. Arabidopsis UV RESISTANCE LOCUS8 (UVR8) specifically mediates these responses by functioning as a UV-B photoreceptor...
  8. Crefcoeur R, Yin R, Ulm R, Halazonetis T. Ultraviolet-B-mediated induction of protein-protein interactions in mammalian cells. Nat Commun. 2013;4:1779 pubmed publisher
    ..optogenetic system based on the ultraviolet-B-dependent interaction of the Arabidopsis ultraviolet-B photoreceptor UVR8 with COP1 that can be performed in visible light background...
  9. Gruber H, Heijde M, Heller W, Albert A, Seidlitz H, Ulm R. Negative feedback regulation of UV-B-induced photomorphogenesis and stress acclimation in Arabidopsis. Proc Natl Acad Sci U S A. 2010;107:20132-7 pubmed publisher
    ..The key players in this UV-B response are COP1 (an E3 ubiquitin ligase), UVR8 (a ?-propeller protein), and HY5 (a bZIP transcription factor)...
  10. Wargent J, Gegas V, Jenkins G, Doonan J, Paul N. UVR8 in Arabidopsis thaliana regulates multiple aspects of cellular differentiation during leaf development in response to ultraviolet B radiation. New Phytol. 2009;183:315-26 pubmed publisher
    ..Arabidopsis thaliana UV RESISTANCE LOCUS8 (UVR8) is the only known UV-B specific signalling component, but the role of UVR8 in leaf morphogenesis is unknown...
  11. Xie L, Lang Mladek C, Richter J, Nigam N, Hauser M. UV-B induction of the E3 ligase ARIADNE12 depends on CONSTITUTIVELY PHOTOMORPHOGENIC 1. Plant Physiol Biochem. 2015;93:18-28 pubmed publisher
    ..photomorphogenic UV-B, ARI12 is a downstream target of the classical ultraviolet B (UV-B) UV Resistance Locus 8 (UVR8) pathway...
  12. Binkert M, Kozma Bognár L, Terecskei K, De Veylder L, Nagy F, Ulm R. UV-B-responsive association of the Arabidopsis bZIP transcription factor ELONGATED HYPOCOTYL5 with target genes, including its own promoter. Plant Cell. 2014;26:4200-13 pubmed publisher
    ..transcription factor ELONGATED HYPOCOTYL5 (HY5) acts downstream of the UV-B photoreceptor UV RESISTANCE LOCUS8 (UVR8) and promotes UV-B-induced photomorphogenesis and acclimation...
  13. Findlay K, Jenkins G. Regulation of UVR8 photoreceptor dimer/monomer photo-equilibrium in Arabidopsis plants grown under photoperiodic conditions. Plant Cell Environ. 2016;39:1706-14 pubmed publisher
    The UV RESISTANCE LOCUS 8 (UVR8) photoreceptor specifically mediates photomorphogenic responses to UV-B. Photoreception induces dissociation of dimeric UVR8 into monomers to initiate responses...
  14. Binkert M, Crocco C, Ekundayo B, Lau K, Raffelberg S, Tilbrook K, et al. Revisiting chromatin binding of the Arabidopsis UV-B photoreceptor UVR8. BMC Plant Biol. 2016;16:42 pubmed publisher
    Plants perceive UV-B through the UV RESISTANCE LOCUS 8 (UVR8) photoreceptor and UVR8 activation leads to changes in gene expression such as those associated with UV-B acclimation and stress tolerance...
  15. Davey M, Susanti N, Wargent J, Findlay J, Paul Quick W, Paul N, et al. The UV-B photoreceptor UVR8 promotes photosynthetic efficiency in Arabidopsis thaliana exposed to elevated levels of UV-B. Photosynth Res. 2012;114:121-31 pubmed publisher
    The UV-B photoreceptor UVR8 regulates expression of genes in response to UV-B, some encoding chloroplast proteins, but the importance of UVR8 in maintaining photosynthetic competence is unknown...
  16. Voityuk A, Marcus R, Michel Beyerle M. On the mechanism of photoinduced dimer dissociation in the plant UVR8 photoreceptor. Proc Natl Acad Sci U S A. 2014;111:5219-24 pubmed publisher
    UV-B absorption by the photoreceptor UV resistance locus 8 (UVR8) consisting of two identical protein units triggers a signal chain used by plants in connection with protection and repair of UV-B induced damage...
  17. Huang X, Yang P, Ouyang X, Chen L, Deng X. Photoactivated UVR8-COP1 module determines photomorphogenic UV-B signaling output in Arabidopsis. PLoS Genet. 2014;10:e1004218 pubmed publisher
    ..ultraviolet (UV)-B-induced photomorphogenesis is initiated by a unique photoreceptor UV resistance locus 8 (UVR8) which utilizes its tryptophan residues as internal chromophore to sense UV-B...
  18. Wu M, Grahn E, Eriksson L, Strid A. Computational evidence for the role of Arabidopsis thaliana UVR8 as UV-B photoreceptor and identification of its chromophore amino acids. J Chem Inf Model. 2011;51:1287-95 pubmed publisher
    A homology model of the Arabidopsis thaliana UV resistance locus 8 (UVR8) protein is presented herein, showing a seven-bladed ?-propeller conformation similar to the globular structure of RCC1...
  19. Mathes T, Heilmann M, Pandit A, Zhu J, Ravensbergen J, Kloz M, et al. Proton-Coupled Electron Transfer Constitutes the Photoactivation Mechanism of the Plant Photoreceptor UVR8. J Am Chem Soc. 2015;137:8113-20 pubmed publisher
    b>UVR8 is a novel UV-B photoreceptor that regulates a range of plant responses and is already used as a versatile optogenetic tool...
  20. Wu Q, Huang B, Niehaus T, Yang X, Fan J, Zhang R. The role of tryptophans in the UV-B absorption of a UVR8 photoreceptor--a computational study. Phys Chem Chem Phys. 2015;17:10786-94 pubmed publisher
    Arabidopsis thaliana UV RESISTANCE LOCUS8 (UVR8) has been identified as a photoreceptor for ultraviolet-B (UV-B). Tryptophan (Trp) residues have been shown to play a critical role in the response to UV-B irradiation in UVR8...
  21. Yin R, Skvortsova M, Loubéry S, Ulm R. COP1 is required for UV-B-induced nuclear accumulation of the UVR8 photoreceptor. Proc Natl Acad Sci U S A. 2016;113:E4415-22 pubmed publisher
    The UV-B photoreceptor UV RESISTANCE LOCUS 8 (UVR8) promotes UV-B acclimation and tolerance in Arabidopsis thaliana UVR8 localizes to both cytosol and nucleus, but its main activity is assumed to be nuclear...
  22. Fasano R, Gonzalez N, Tosco A, Dal Piaz F, Docimo T, Serrano R, et al. Role of Arabidopsis UV RESISTANCE LOCUS 8 in plant growth reduction under osmotic stress and low levels of UV-B. Mol Plant. 2014;7:773-91 pubmed publisher
    ..Here, we report that the Arabidopsis thaliana UV RESISTANCE LOCUS 8 (UVR8) gene, a known regulator of the UV-B morphogenic response, was able to complement a Saccharomyces cerevisiae osmo-..
  23. Wu M, Strid A, Eriksson L. Interactions and stabilities of the UV RESISTANCE LOCUS8 (UVR8) protein dimer and its key mutants. J Chem Inf Model. 2013;53:1736-46 pubmed publisher
    The dimeric UVR8 protein is an ultraviolet-B radiation (280-315 nm) photoreceptor responsible for the first step in UV-B regulation of gene expression in plants...
  24. Velanis C, Herzyk P, Jenkins G. Regulation of transcription by the Arabidopsis UVR8 photoreceptor involves a specific histone modification. Plant Mol Biol. 2016;92:425-443 pubmed
    The photoreceptor UV RESISTANCE LOCUS 8 (UVR8) specifically mediates photomorphogenic responses to UV-B wavelengths. UVR8 acts by regulating transcription of a set of genes, but the underlying mechanisms are unknown...
  25. Horak E, Farré E. The regulation of UV-B responses by the circadian clock. Plant Signal Behav. 2015;10:e1000164 pubmed publisher
    ..We also discuss the potential mechanisms involved in this process and the role of the circadian clock in the acclimation to UV-B. ..
  26. Tossi V, Lamattina L, Jenkins G, Cassia R. Ultraviolet-B-induced stomatal closure in Arabidopsis is regulated by the UV RESISTANCE LOCUS8 photoreceptor in a nitric oxide-dependent mechanism. Plant Physiol. 2014;164:2220-30 pubmed publisher
    UV RESISTANCE LOCUS8 (UVR8) signaling involves CONSTITUTIVELY PHOTOMORPHOGENIC1, the ELONGATED HYPOCOTYL5 (HY5) transcription factor, and the closely related HY5 HOMOLOG...
  27. Hayes S, Velanis C, Jenkins G, Franklin K. UV-B detected by the UVR8 photoreceptor antagonizes auxin signaling and plant shade avoidance. Proc Natl Acad Sci U S A. 2014;111:11894-9 pubmed publisher
    ..UV-B is perceived by the photoreceptor UV RESISTANCE LOCUS 8 (UVR8). The molecular mechanisms linking UVR8 activation to plant growth are not fully understood, however...
  28. González Besteiro M, Bartels S, Albert A, Ulm R. Arabidopsis MAP kinase phosphatase 1 and its target MAP kinases 3 and 6 antagonistically determine UV-B stress tolerance, independent of the UVR8 photoreceptor pathway. Plant J. 2011;68:727-37 pubmed publisher
    Plants perceive UV-B radiation as an informational signal by a pathway involving UVR8 as UV-B photoreceptor, activating photomorphogenic and acclimation responses...
  29. Bernula P, Crocco C, Arongaus A, Ulm R, Nagy F, Viczian A. Expression of the UVR8 photoreceptor in different tissues reveals tissue-autonomous features of UV-B signalling. Plant Cell Environ. 2017;40:1104-1114 pubmed publisher
    The Arabidopsis UV-B photoreceptor UV RESISTANCE LOCUS 8 (UVR8) orchestrates the expression of hundreds of genes, many of which can be associated with UV-B tolerance...
  30. Yin R, Arongaus A, Binkert M, Ulm R. Two distinct domains of the UVR8 photoreceptor interact with COP1 to initiate UV-B signaling in Arabidopsis. Plant Cell. 2015;27:202-13 pubmed publisher
    UV-B photon reception by the Arabidopsis thaliana homodimeric UV RESISTANCE LOCUS8 (UVR8) photoreceptor leads to its monomerization and a crucial interaction with CONSTITUTIVELY PHOTOMORPHOGENIC1 (COP1)...
  31. Morales L, Brosché M, Vainonen J, Jenkins G, Wargent J, Sipari N, et al. Multiple roles for UV RESISTANCE LOCUS8 in regulating gene expression and metabolite accumulation in Arabidopsis under solar ultraviolet radiation. Plant Physiol. 2013;161:744-59 pubmed publisher
    ..rates of ultraviolet B radiation (UV-B; 280-315 nm) are mediated by the UV-B photoreceptor UV RESISTANCE LOCUS8 (UVR8)...
  32. Liu Y, Liu Q, Yan Q, Shi L, Fang Y. Nucleolus-tethering system (NoTS) reveals that assembly of photobodies follows a self-organization model. Mol Biol Cell. 2014;25:1366-73 pubmed publisher