Gene Symbol: UPF3
Description: Smg-4/UPF3 family protein
Alias: ATUPF3, F12G12.20, F12G12_20, Smg-4/UPF3 family protein
Species: thale cress

Top Publications

  1. Shi C, Baldwin I, Wu J. Arabidopsis plants having defects in nonsense-mediated mRNA decay factors UPF1, UPF2, and UPF3 show photoperiod-dependent phenotypes in development and stress responses. J Integr Plant Biol. 2012;54:99-114 pubmed publisher
    ..Three NMD factor proteins, UPF1, UPF2, and UPF3 are required for the NMD process and were found to be also involved in certain stress responses in mammalian and ..
  2. Schöning J, Streitner C, Page D, Hennig S, Uchida K, Wolf E, et al. Auto-regulation of the circadian slave oscillator component AtGRP7 and regulation of its targets is impaired by a single RNA recognition motif point mutation. Plant J. 2007;52:1119-30 pubmed
    ..In mutants impaired in the nonsense-mediated decay (NMD) components UPF1 or UPF3, levels of the alternatively spliced AtGRP7 and AtGRP8 transcripts that contain premature termination codons are ..
  3. Kim S, Koroleva O, Lewandowska D, Pendle A, Clark G, Simpson C, et al. Aberrant mRNA transcripts and the nonsense-mediated decay proteins UPF2 and UPF3 are enriched in the Arabidopsis nucleolus. Plant Cell. 2009;21:2045-57 pubmed publisher
    ..In addition, the NMD factors UPF3 and UPF2 localize to the nucleolus, suggesting that the Arabidopsis nucleolus is therefore involved in identifying ..
  4. Hori K, Watanabe Y. UPF3 suppresses aberrant spliced mRNA in Arabidopsis. Plant J. 2005;43:530-40 pubmed
    ..ratios in wild-type Arabidopsis and upf3 mutant plants and showed that the PTC+/PTC- ratios were higher in atupf3 mutant plants than wild-type plants and that the atupf3 mutant was less able to degrade mRNAs with premature ..
  5. Degtiar E, Fridman A, Gottlieb D, Vexler K, Berezin I, Farhi R, et al. The feedback control of UPF3 is crucial for RNA surveillance in plants. Nucleic Acids Res. 2015;43:4219-35 pubmed publisher
    ..The regulation of this process is not well understood. The Arabidopsis NMD factor UPF3 is regulated by a negative feedback-loop that targets its own transcript for NMD...
  6. Kurihara Y, Matsui A, Hanada K, Kawashima M, Ishida J, Morosawa T, et al. Genome-wide suppression of aberrant mRNA-like noncoding RNAs by NMD in Arabidopsis. Proc Natl Acad Sci U S A. 2009;106:2453-8 pubmed publisher
    ..The UP-Frameshift (UPF) proteins, UPF1, UPF2, and UPF3, are essential for normal NMD function...
  7. Jeong H, Kim Y, Kim S, Kim Y, Lee I, Kim Y, et al. Nonsense-mediated mRNA decay factors, UPF1 and UPF3, contribute to plant defense. Plant Cell Physiol. 2011;52:2147-56 pubmed publisher
    In Arabidopsis, the NMD-defective mutants upf1-5 and upf3-1 are characterized by dwarfism, curly leaves and late flowering...
  8. Palusa S, Reddy A. Extensive coupling of alternative splicing of pre-mRNAs of serine/arginine (SR) genes with nonsense-mediated decay. New Phytol. 2010;185:83-9 pubmed publisher
    ..the abundances of all splice variants for each alternatively spliced gene in an Arabidopsis mutant that lacks UPF3, one of the core components of NMD machinery, to determine if the PTC-containing transcripts are degraded by NMD...