Gene Symbol: TWD1
Description: FKBP-type peptidyl-prolyl cis-trans isomerase family protein
Alias: ATFKBP42, FK506-BINDING PROTEIN 42, FKBP42, TWISTED DWARF 1, UCU2, ULTRACURVATA 2, FKBP-type peptidyl-prolyl cis-trans isomerase family protein
Species: thale cress
Kamphausen T, Fanghanel J, Neumann D, Schulz B, Rahfeld J. Characterization of Arabidopsis thaliana AtFKBP42 that is membrane-bound and interacts with Hsp90. Plant J. 2002;32:263-76 pubmed
..The TWD1 gene encodes a 42 kDa FK506-binding protein (AtFKBP42) that possesses similarity to multidomain PPIases such as mammalian FKBP51 and FKBP52, which are known to be ..
Geisler M, Girin M, Brandt S, Vincenzetti V, Plaza S, Paris N, et al
. Arabidopsis immunophilin-like TWD1 functionally interacts with vacuolar ABC transporters. Mol Biol Cell. 2004;15:3393-405 pubmed
Previously, the immunophilin-like protein TWD1 from Arabidopsis has been demonstrated to interact with the ABC transporters AtPGP1 and its closest homologue, AtPGP19...
Geisler M, Kolukisaoglu H, Bouchard R, Billion K, Berger J, Saal B, et al
. TWISTED DWARF1, a unique plasma membrane-anchored immunophilin-like protein, interacts with Arabidopsis multidrug resistance-like transporters AtPGP1 and AtPGP19. Mol Biol Cell. 2003;14:4238-49 pubmed
Null-mutations of the Arabidopsis FKBP-like immunophilin TWISTED DWARF1 (TWD1) gene cause a pleiotropic phenotype characterized by reduction of cell elongation and disorientated growth of all plant organs...
Granzin J, Eckhoff A, Weiergräber O. Crystal structure of a multi-domain immunophilin from Arabidopsis thaliana: a paradigm for regulation of plant ABC transporters. J Mol Biol. 2006;364:799-809 pubmed
b>FKBP42 is a membrane-anchored immunophilin playing a critical role in morphogenesis and development of higher plants...
Bouchard R, Bailly A, Blakeslee J, Oehring S, Vincenzetti V, Lee O, et al
. Immunophilin-like TWISTED DWARF1 modulates auxin efflux activities of Arabidopsis P-glycoproteins. J Biol Chem. 2006;281:30603-12 pubmed
The immunophilin-like protein TWISTED DWARF1 (TWD1/FKBP42) has been shown to physically interact with the multidrug resistance/P-glycoprotein (PGP) ATP-binding cassette transporters PGP1 and PGP19 (MDR1)...
Zhao B, Lv M, Feng Z, Campbell T, Liscum E, Li J. TWISTED DWARF 1 Associates with BRASSINOSTEROID-INSENSITIVE 1 to Regulate Early Events of the Brassinosteroid Signaling Pathway. Mol Plant. 2016;9:582-92 pubmed publisher
..BR) sensitivity or bri1-like phenotypes resulted in the identification of two new mutant alleles of TWISTED DWARF 1 (TWD1), twd1-4, and twd1-5...
Henrichs S, Wang B, Fukao Y, Zhu J, Charrier L, Bailly A, et al
. Regulation of ABCB1/PGP1-catalysed auxin transport by linker phosphorylation. EMBO J. 2012;31:2965-80 pubmed publisher
..by the AGC protein kinase, PINOID (PID), while ABCB activity was shown to be dependent on interaction with the FKBP42, TWISTED DWARF1 (TWD1)...
Chaiwanon J, Garcia V, Cartwright H, Sun Y, Wang Z. Immunophilin-like FKBP42/TWISTED DWARF1 Interacts with the Receptor Kinase BRI1 to Regulate Brassinosteroid Signaling in Arabidopsis. Mol Plant. 2016;9:593-600 pubmed publisher
Mutation of the immunophilin-like FK506-binding protein TWISTED DWARF1 (FKBP42/TWD1) causes dwarf and twisted-organ phenotypes in Arabidopsis. However, the function of FKBP42 is not fully understood at the molecular level...
Wang B, Bailly A, Zwiewka M, Henrichs S, Azzarello E, Mancuso S, et al
. Arabidopsis TWISTED DWARF1 functionally interacts with auxin exporter ABCB1 on the root plasma membrane. Plant Cell. 2013;25:202-14 pubmed publisher
..The latter were shown to require the functionality of the FK506 binding protein42 TWISTED DWARF1 (TWD1), although underlying mechanisms are unclear...