Gene Symbol: TIL1
Description: DNA polymerase epsilon catalytic subunit
Alias: ABA OVERLY SENSITIVE 4, ABO4, EARLY IN SHORT DAYS 7, EMB142, EMB2284, EMB529, EMBRYO DEFECTIVE 142, EMBRYO DEFECTIVE 2284, EMBRYO DEFECTIVE 529, ESD7, POL2A, T23G18.21, T23G18_21, TILTED 1, DNA polymerase epsilon catalytic subunit
Species: thale cress

Top Publications

  1. Jenik P, Jurkuta R, Barton M. Interactions between the cell cycle and embryonic patterning in Arabidopsis uncovered by a mutation in DNA polymerase epsilon. Plant Cell. 2005;17:3362-77 pubmed
    ..The results uncover an interaction between the cell cycle and the processes that determine cell fate during plant embryogenesis. ..
  2. Ronceret A, Guilleminot J, Lincker F, Gadea Vacas J, Delorme V, Bechtold N, et al. Genetic analysis of two Arabidopsis DNA polymerase epsilon subunits during early embryogenesis. Plant J. 2005;44:223-36 pubmed
    ..Our results support the idea that fertilization may utilize the mechanisms of cell cycle transcriptional regulation of genes to reactivate the divisions of the oosphere and central cell. ..
  3. Del Olmo I, López J, Vázquez J, Raynaud C, Piñeiro M, Jarillo J. Arabidopsis DNA polymerase ϵ recruits components of Polycomb repressor complex to mediate epigenetic gene silencing. Nucleic Acids Res. 2016;44:5597-614 pubmed publisher
    Arabidopsis ESD7 locus encodes the catalytic subunit of the DNA Pol ϵ involved in the synthesis of the DNA leading strand and is essential for embryo viability...
  4. Pedroza García J, Mazubert C, del Olmo I, Bourge M, Domenichini S, Bounon R, et al. Function of the Plant DNA Polymerase Epsilon in Replicative Stress Sensing, a Genetic Analysis. Plant Physiol. 2017;173:1735-1749 pubmed publisher
  5. Yin H, Zhang X, Liu J, Wang Y, He J, Yang T, et al. Epigenetic regulation, somatic homologous recombination, and abscisic acid signaling are influenced by DNA polymerase epsilon mutation in Arabidopsis. Plant Cell. 2009;21:386-402 pubmed publisher
    ..assays, we isolated an ABA overly sensitive mutant (abo4-1) caused by a mutation in the Arabidopsis thaliana POL2a/TILTED1(TIL1) gene encoding a catalytic subunit of DNA polymerase epsilon...
  6. del Olmo I, López González L, Martín Trillo M, Martinez Zapater J, Piñeiro M, Jarillo J. EARLY IN SHORT DAYS 7 (ESD7) encodes the catalytic subunit of DNA polymerase epsilon and is required for flowering repression through a mechanism involving epigenetic gene silencing. Plant J. 2010;61:623-36 pubmed publisher
    We have characterized a mutation affecting the Arabidopsis EARLY IN SHORT DAYS 7 (ESD7) gene encoding the catalytic subunit of DNA polymerase epsilon (epsilon), AtPOL2a...
  7. Huang J, Cheng Z, Wang C, Hong Y, Su H, Wang J, et al. Formation of interference-sensitive meiotic cross-overs requires sufficient DNA leading-strand elongation. Proc Natl Acad Sci U S A. 2015;112:12534-9 pubmed publisher
    ..Here, we show that Arabidopsis POL2A, the homolog of the yeast DNA polymerase-ε (a leading-strand DNA polymerase), is required for plant fertility ..