Gene Symbol: SUMO1
Description: small ubiquitin-like modifier 1
Alias: ARABIDOPSIS THALIANA SMALL UBIQUITIN-LIKE MODIFIER 1, ATSUMO1, F10M23.180, F10M23_180, SMALL UBIQUITIN-LIKE MODIFIER 1, SUM1, SUMO 1, small ubiquitin-like modifier 1, small ubiquitin-like modifier 1
Species: thale cress
Products:     SUMO1

Top Publications

  1. Garcia Dominguez M, March Diaz R, Reyes J. The PHD domain of plant PIAS proteins mediates sumoylation of bromodomain GTE proteins. J Biol Chem. 2008;283:21469-77 pubmed publisher
    ..Based on the capacity of AtSCE1 and GTE3 to associate with both the PHD and SP-RING domains, we propose a model of interactions to explain AtSIZ1-mediated sumoylation of GTE3 and ligase function of the PHD domain. ..
  2. Lois L, Lima C, Chua N. Small ubiquitin-like modifier modulates abscisic acid signaling in Arabidopsis. Plant Cell. 2003;15:1347-59 pubmed
    ..We report the identification and functional analysis of AtSUMO1, AtSUMO2, and AtSCE1a as components of the SUMO conjugation (sumoylation) pathway in Arabidopsis...
  3. Chosed R, Mukherjee S, Lois L, Orth K. Evolution of a signalling system that incorporates both redundancy and diversity: Arabidopsis SUMOylation. Biochem J. 2006;398:521-9 pubmed
    ..Therefore the SUMO proteins, in this signalling system, have evolved to contain information that allows not only redundancy with the conjugation system but also diversity with the deconjugating enzymes. ..
  4. Miura K, Lee J, Jin J, Yoo C, Miura T, Hasegawa P. Sumoylation of ABI5 by the Arabidopsis SUMO E3 ligase SIZ1 negatively regulates abscisic acid signaling. Proc Natl Acad Sci U S A. 2009;106:5418-23 pubmed publisher
    ..The double mutant siz1-2 afp-1 exhibited even greater ABA sensitivity than the single mutant siz1, suggesting that SIZ1 represses ABI5 signaling function independent of AFP1. ..
  5. Okada S, Nagabuchi M, Takamura Y, Nakagawa T, Shinmyozu K, Nakayama J, et al. Reconstitution of Arabidopsis thaliana SUMO pathways in E. coli: functional evaluation of SUMO machinery proteins and mapping of SUMOylation sites by mass spectrometry. Plant Cell Physiol. 2009;50:1049-61 pubmed publisher
    ..We tested the ability of this system to conjugate the Arabidopsis SUMO isoforms, AtSUMO1, 2, 3 and 5, to a model substrate, AtMYB30, which is an Arabidopsis transcription factor...
  6. Kurepa J, Walker J, Smalle J, Gosink M, Davis S, Durham T, et al. The small ubiquitin-like modifier (SUMO) protein modification system in Arabidopsis. Accumulation of SUMO1 and -2 conjugates is increased by stress. J Biol Chem. 2003;278:6862-72 pubmed
    ..A diverse array of conjugates could be detected, some of which appear to be SUMO isoform-specific. The levels of SUMO1 and -2 conjugates but not SUMO3 conjugates increased substantially following exposure of seedlings to stress ..
  7. Miller M, Barrett Wilt G, Hua Z, Vierstra R. Proteomic analyses identify a diverse array of nuclear processes affected by small ubiquitin-like modifier conjugation in Arabidopsis. Proc Natl Acad Sci U S A. 2010;107:16512-7 pubmed publisher
    ..developed a stringent method to isolate SUMO-protein conjugates from Arabidopsis thaliana that exploits a tagged SUMO1 variant that faithfully replaces the wild-type protein...
  8. Miura K, Jin J, Lee J, Yoo C, Stirm V, Miura T, et al. SIZ1-mediated sumoylation of ICE1 controls CBF3/DREB1A expression and freezing tolerance in Arabidopsis. Plant Cell. 2007;19:1403-14 pubmed
    ..SIZ1-dependent sumoylation of ICE1 may activate and/or stabilize the protein, facilitating expression of CBF3/DREB1A and repression of MYB15, leading to low temperature tolerance...
  9. Saracco S, Miller M, Kurepa J, Vierstra R. Genetic analysis of SUMOylation in Arabidopsis: conjugation of SUMO1 and SUMO2 to nuclear proteins is essential. Plant Physiol. 2007;145:119-34 pubmed
    ..Through genetic analyses of various SUMO conjugation mutants, we show here that the SUMO1 and SUMO2 isoforms, in particular, and SUMOylation, in general, are essential for viability in Arabidopsis (..

More Information


  1. Budhiraja R, Hermkes R, Muller S, Schmidt J, Colby T, Panigrahi K, et al. Substrates related to chromatin and to RNA-dependent processes are modified by Arabidopsis SUMO isoforms that differ in a conserved residue with influence on desumoylation. Plant Physiol. 2009;149:1529-40 pubmed publisher
    ..We tested deviations in this position in the background of SUMO1, the isoform with the highest expression level, and found that changes do not prevent conjugation to substrate ..
  2. Elrouby N, Coupland G. Proteome-wide screens for small ubiquitin-like modifier (SUMO) substrates identify Arabidopsis proteins implicated in diverse biological processes. Proc Natl Acad Sci U S A. 2010;107:17415-20 pubmed publisher
    ..These proteins provide a basis for exploring the function of SUMOylation in the regulation of diverse processes in Arabidopsis. ..
  3. Cohen Peer R, Schuster S, Meiri D, Breiman A, Avni A. Sumoylation of Arabidopsis heat shock factor A2 (HsfA2) modifies its activity during acquired thermotholerance. Plant Mol Biol. 2010;74:33-45 pubmed publisher
    ..Using the Yeast two hybrid and the bimolecular fluorescence complementation system, we have found that AtSUMO1 physically interacts with AtHsfA2...
  4. Tomanov K, Ziba I, Bachmair A. SUMO Chain Formation by Plant Enzymes. Methods Mol Biol. 2016;1450:97-105 pubmed publisher
    ..cerevisiae has only one SUMO protein, humans have four and Arabidopsis thaliana has eight, the main isoforms being SUMO1 and SUMO2 with about 95 % identity...
  5. Conti L, Nelis S, Zhang C, Woodcock A, Swarup R, Galbiati M, et al. Small Ubiquitin-like Modifier protein SUMO enables plants to control growth independently of the phytohormone gibberellin. Dev Cell. 2014;28:102-10 pubmed publisher
    ..We conclude that plants have developed a GA-independent mechanism to control growth. ..
  6. Bar M, Schuster S, Leibman M, Ezer R, Avni A. The function of EHD2 in endocytosis and defense signaling is affected by SUMO. Plant Mol Biol. 2014;84:509-18 pubmed publisher
  7. Elrouby N, Bonequi M, Porri A, Coupland G. Identification of Arabidopsis SUMO-interacting proteins that regulate chromatin activity and developmental transitions. Proc Natl Acad Sci U S A. 2013;110:19956-61 pubmed publisher
    ..It reduces protein levels of CYCLING DOF FACTOR 2, hence increasing transcript levels of CONSTANS and promoting flowering through the photoperiodic pathway. ..
  8. Park B, Song J, Seo H. Arabidopsis nitrate reductase activity is stimulated by the E3 SUMO ligase AtSIZ1. Nat Commun. 2011;2:400 pubmed publisher
    ..Both sumoylated and non-sumoylated NIA1 and NIA2 can form dimers. Our results indicate that AtSIZ1 positively controls nitrogen assimilation by promoting sumoylation of NRs in Arabidopsis. ..
  9. Castaño Miquel L, Seguí J, Lois L. Distinctive properties of Arabidopsis SUMO paralogues support the in vivo predominant role of AtSUMO1/2 isoforms. Biochem J. 2011;436:581-90 pubmed publisher
    ..the present paper, we show data contributing to the notion that the four expressed Arabidopsis SUMO paralogues, AtSUMO1, 2, 3 and 5, have functionally diverged to a higher extent than their human orthologues...
  10. Nelis S, Conti L, Zhang C, Sadanandom A. A functional Small Ubiquitin-like Modifier (SUMO) interacting motif (SIM) in the gibberellin hormone receptor GID1 is conserved in cereal crops and disrupting this motif does not abolish hormone dependency of the DELLA-GID1 interaction. Plant Signal Behav. 2015;10:e987528 pubmed publisher
    ..We demonstrate that GID1 proteins across the major cereal crops contain a functional SIM able to bind SUMO1. Site directed mutagenesis and yeast 2 hybrid experiments reveal that it is possible to disrupt the SIM-SUMO ..
  11. van den Burg H, Kini R, Schuurink R, Takken F. Arabidopsis small ubiquitin-like modifier paralogs have distinct functions in development and defense. Plant Cell. 2010;22:1998-2016 pubmed publisher
    ..We studied the function of these paralogs. Single mutants of the SUM1 and SUM2 paralogs do not exhibit a clear phenotype...
  12. Lin X, Niu D, Hu Z, Kim D, Jin Y, Cai B, et al. An Arabidopsis SUMO E3 Ligase, SIZ1, Negatively Regulates Photomorphogenesis by Promoting COP1 Activity. PLoS Genet. 2016;12:e1006016 pubmed publisher
    ..Our genetic and biochemical studies identify a function for SIZ1 in photomorphogenesis and reveal a novel SUMO-regulated ubiquitin ligase, COP1, in plants. ..