Gene Symbol: SPINDLY
Description: Tetratricopeptide repeat (TPR)-like superfamily protein
Alias: SPINDLY, Tetratricopeptide repeat (TPR)-like superfamily protein
Species: thale cress

Top Publications

  1. Swain S, Tseng T, Thornton T, Gopalraj M, Olszewski N. SPINDLY is a nuclear-localized repressor of gibberellin signal transduction expressed throughout the plant. Plant Physiol. 2002;129:605-15 pubmed
    SPY (SPINDLY) encodes a putative O-linked N-acetyl-glucosamine transferase that is genetically defined as a negatively acting component of the gibberellin (GA) signal transduction pathway...
  2. Tseng T, Salome P, McClung C, Olszewski N. SPINDLY and GIGANTEA interact and act in Arabidopsis thaliana pathways involved in light responses, flowering, and rhythms in cotyledon movements. Plant Cell. 2004;16:1550-63 pubmed
    b>SPINDLY (SPY) is a negative regulator of gibberellin signaling in Arabidopsis thaliana that also functions in previously undefined pathways...
  3. Greenboim Wainberg Y, Maymon I, Borochov R, Alvarez J, Olszewski N, Ori N, et al. Cross talk between gibberellin and cytokinin: the Arabidopsis GA response inhibitor SPINDLY plays a positive role in cytokinin signaling. Plant Cell. 2005;17:92-102 pubmed
    b>SPINDLY (SPY) is a negative regulator of gibberellin (GA) responses; however, spy mutants exhibit various phenotypic alterations not found in GA-treated plants...
  4. Achard P, Renou J, Berthomé R, Harberd N, Genschik P. Plant DELLAs restrain growth and promote survival of adversity by reducing the levels of reactive oxygen species. Curr Biol. 2008;18:656-60 pubmed publisher
    ..We therefore propose that environmental variability regulates DELLA activity [8] and that DELLAs in turn couple the downstream regulation of plant growth and stress tolerance through modulation of ROS levels. ..
  5. Qin F, Kodaira K, Maruyama K, Mizoi J, Tran L, Fujita Y, et al. SPINDLY, a negative regulator of gibberellic acid signaling, is involved in the plant abiotic stress response. Plant Physiol. 2011;157:1900-13 pubmed publisher
    The SPINDLY (SPY) gene was first identified as a negative regulator of plant gibberellic acid (GA) signaling because mutation of this gene phenocopies plants treated with an overdose of bioactive GA and results in insensitivity to a GA ..
  6. Steiner E, Efroni I, Gopalraj M, Saathoff K, Tseng T, Kieffer M, et al. The Arabidopsis O-linked N-acetylglucosamine transferase SPINDLY interacts with class I TCPs to facilitate cytokinin responses in leaves and flowers. Plant Cell. 2012;24:96-108 pubmed publisher
    ..The Arabidopsis thaliana O-GlcNAc transferase (OGT) SPINDLY (SPY) suppresses gibberellin signaling and promotes cytokinin (CK) responses by unknown mechanisms...
  7. Thornton -, Swain -, Olszewski -. Gibberellin signal transduction presents ellipsisthe SPY who O-GlcNAc'd me. Trends Plant Sci. 1999;4:424-428 pubmed
    ..One component of the pathway, SPINDLY, is believed to be an O-GlcNAc transferase that post-translationally modifies cytosolic and nuclear proteins by ..
  8. Tseng T, Swain S, Olszewski N. Ectopic expression of the tetratricopeptide repeat domain of SPINDLY causes defects in gibberellin response. Plant Physiol. 2001;126:1250-8 pubmed
    The SPINDLY (SPY) protein of Arabidopsis is a negative regulator of gibberellin (GA) response. The SPY protein has 10 copies of the tetratricopeptide repeat (TPR) at the N terminus...
  9. Cuéllar Pérez A, Nagels Durand A, Vanden Bossche R, De Clercq R, Persiau G, van Wees S, et al. The non-JAZ TIFY protein TIFY8 from Arabidopsis thaliana is a transcriptional repressor. PLoS ONE. 2014;9:e84891 pubmed publisher
    ..In contrast, TIFY8 was found in protein complexes involved in regulation of dephosphorylation, deubiquitination and O-linked N-acetylglucosamine modification suggesting an important role in nuclear signal transduction. ..

More Information


  1. Cui H, Kong D, Wei P, Hao Y, Torii K, Lee J, et al. SPINDLY, ERECTA, and its ligand STOMAGEN have a role in redox-mediated cortex proliferation in the Arabidopsis root. Mol Plant. 2014;7:1727-39 pubmed publisher
    ..We here report that hydrogen peroxide induces cortex proliferation in the Arabidopsis root and that SPINDLY (SPY), an O-linked glucosamine acetyltransferase, regulates cortex proliferation by maintaining cellular redox ..
  2. Maymon I, Greenboim Wainberg Y, Sagiv S, Kieber J, Moshelion M, Olszewski N, et al. Cytosolic activity of SPINDLY implies the existence of a DELLA-independent gibberellin-response pathway. Plant J. 2009;58:979-88 pubmed publisher
    ..Coordination of the two pathways involves the O-linked N-acetylglucosamine transferase SPINDLY (SPY) that suppresses GA signaling and promotes cytokinin responses in Arabidopsis...
  3. Sarnowska E, Rolicka A, Bucior E, Cwiek P, Tohge T, Fernie A, et al. DELLA-interacting SWI3C core subunit of switch/sucrose nonfermenting chromatin remodeling complex modulates gibberellin responses and hormonal cross talk in Arabidopsis. Plant Physiol. 2013;163:305-17 pubmed publisher
    ..Furthermore, we show that SWI3C also interacts with the O-GlcNAc (O-linked N-acetylglucosamine) transferase SPINDLY required for proper functioning of DELLAs and acts hypostatically to (SPINDLY) in the GA response pathway...
  4. Steiner E, Livne S, Kobinson Katz T, Tal L, Pri Tal O, Mosquna A, et al. The Putative O-Linked N-Acetylglucosamine Transferase SPINDLY Inhibits Class I TCP Proteolysis to Promote Sensitivity to Cytokinin. Plant Physiol. 2016;171:1485-94 pubmed publisher
    Arabidopsis (Arabidopsis thaliana) SPINDLY (SPY) is a putative serine and threonine O-linked N-acetylglucosamine transferase (OGT)...
  5. Zentella R, Sui N, Barnhill B, Hsieh W, Hu J, Shabanowitz J, et al. The Arabidopsis O-fucosyltransferase SPINDLY activates nuclear growth repressor DELLA. Nat Chem Biol. 2017;13:479-485 pubmed publisher
    ..Here, we found that DELLA is mono-O-fucosylated by the novel O-fucosyltransferase SPINDLY (SPY) in Arabidopsis thaliana...
  6. Jacobsen S, Olszewski N, Meyerowitz E. SPINDLY's role in the gibberellin response pathway. Symp Soc Exp Biol. 1998;51:73-8 pubmed
    The SPINDLY (SPY) locus of Arabidopsis thaliana is believed to be involved in gibberellin (GA) signal transduction...