SPHK1

Summary

Gene Symbol: SPHK1
Description: sphingosine kinase 1
Alias: F18E5.160, F18E5_160, sphingosine kinase 1, sphingosine kinase 1
Species: thale cress
Products:     SPHK1

Top Publications

  1. Coursol S, Le Stunff H, Lynch D, Gilroy S, Assmann S, Spiegel S. Arabidopsis sphingosine kinase and the effects of phytosphingosine-1-phosphate on stomatal aperture. Plant Physiol. 2005;137:724-37 pubmed
    ..In contrast, mammalian SphK1 efficiently phosphorylated Sph, dihydrosphingosine, and 4,8-sphingadienine, but not the 4-hydroxylated long-chain ..
  2. Marion J, Bach L, Bellec Y, Meyer C, Gissot L, Faure J. Systematic analysis of protein subcellular localization and interaction using high-throughput transient transformation of Arabidopsis seedlings. Plant J. 2008;56:169-79 pubmed publisher
  3. Guo L, Mishra G, Taylor K, Wang X. Phosphatidic acid binds and stimulates Arabidopsis sphingosine kinases. J Biol Chem. 2011;286:13336-45 pubmed publisher
    ..b>SPHK1 and SPHK2 exhibited strong binding to 18:1/18:1, 16:0/18:1, and 16:0/18:2 PA, but poor binding to 16:0/16:0, 8:0/8:..
  4. Worrall D, Liang Y, Alvarez S, Holroyd G, Spiegel S, Panagopulos M, et al. Involvement of sphingosine kinase in plant cell signalling. Plant J. 2008;56:64-72 pubmed publisher
    ..We show that Sphingosine kinase1 (SPHK1) encodes an enzyme that phosphorylates sphingosine, phytosphingosine and other sphingoid long-chain bases...
  5. Guo L, Mishra G, Markham J, Li M, Tawfall A, Welti R, et al. Connections between sphingosine kinase and phospholipase D in the abscisic acid signaling pathway in Arabidopsis. J Biol Chem. 2012;287:8286-96 pubmed publisher
    ..the cellular and physiological functions of the PA-SPHK interaction, we isolated Arabidopsis thaliana SPHK mutants sphk1-1 and sphk2-1 and characterized them, together with phospholipase D?1 knock-out, pld?1, in plant response to ABA...
  6. Qin X, Zhang R, Ge S, Zhou T, Liang Y. Sphingosine kinase AtSPHK1 functions in fumonisin B1-triggered cell death in Arabidopsis. Plant Physiol Biochem. 2017;119:70-80 pubmed publisher
    ..Here, we report sphingosine kinase 1 (SPHK1) as a key factor in FB1-induced HR by modulating the salicylic acid (SA) pathway and reactive oxygen ..