Gene Symbol: SPA4
Description: SPA1-related 4
Alias: F8L10.5, F8L10_5, SPA1-related 4, SPA1-related 4
Species: thale cress
Liu B, Zuo Z, Liu H, Liu X, Lin C. Arabidopsis cryptochrome 1 interacts with SPA1 to suppress COP1 activity in response to blue light. Genes Dev. 2011;25:1029-34 pubmed publisher
..These results are consistent with a hypothesis that photoexcited CRY1 interacts with SPA1 to modulate COP1 activity and plant development. ..
Maier A, Schrader A, Kokkelink L, Falke C, Welter B, Iniesto E, et al
. Light and the E3 ubiquitin ligase COP1/SPA control the protein stability of the MYB transcription factors PAP1 and PAP2 involved in anthocyanin accumulation in Arabidopsis. Plant J. 2013;74:638-51 pubmed publisher
..Thus, our findings have identified mechanisms via which the COP1/SPA complex controls anthocyanin levels in Arabidopsis that may be useful for applications in biotechnology directed towards increasing anthocyanin content in plants. ..
Laubinger S, Hoecker U. The SPA1-like proteins SPA3 and SPA4 repress photomorphogenesis in the light. Plant J. 2003;35:373-85 pubmed
..of a small gene family comprising three genes: SPA1-related 2 (SPA2), SPA1-related 3 (SPA3), and SPA1-related 4 (SPA4)...
Zhu D, Maier A, Lee J, Laubinger S, Saijo Y, Wang H, et al
. Biochemical characterization of Arabidopsis complexes containing CONSTITUTIVELY PHOTOMORPHOGENIC1 and SUPPRESSOR OF PHYA proteins in light control of plant development. Plant Cell. 2008;20:2307-23 pubmed publisher
..This study thus provides an in-depth biochemical view of the SPA-COP1 E3 ligase complexes and offers new insights into the molecular basis for their distinct roles in the light control of plant development. ..
Balcerowicz M, Kerner K, Schenkel C, Hoecker U. SPA Proteins Affect the Subcellular Localization of COP1 in the COP1/SPA Ubiquitin Ligase Complex during Photomorphogenesis. Plant Physiol. 2017;174:1314-1321 pubmed publisher
Rolauffs S, Fackendahl P, Sahm J, Fiene G, Hoecker U. Arabidopsis COP1 and SPA genes are essential for plant elongation but not for acceleration of flowering time in response to a low red light to far-red light ratio. Plant Physiol. 2012;160:2015-27 pubmed publisher
..We propose that COP1/SPA activity, via LONG HYPOCOTYL IN FR LIGHT1, is required for shade-induced modulation of the auxin biosynthesis pathway and thereby enhances cell elongation in low R:FR. ..
Heijde M, Binkert M, Yin R, Ares Orpel F, Rizzini L, Van De Slijke E, et al
. Constitutively active UVR8 photoreceptor variant in Arabidopsis. Proc Natl Acad Sci U S A. 2013;110:20326-31 pubmed publisher
..We conclude that UVR8(W285A) is a constitutively active UVR8 photoreceptor variant in Arabidopsis, as is consistent with the crucial importance of monomer formation and COP1 binding for UVR8 activity. ..
Laubinger S, Marchal V, Le Gourrierec J, Gentilhomme J, Wenkel S, Adrian J, et al
. Arabidopsis SPA proteins regulate photoperiodic flowering and interact with the floral inducer CONSTANS to regulate its stability. Development. 2006;133:3213-22 pubmed
..short day (SD) but not long day (LD) conditions, and this phenotype is enhanced by additional loss of SPA3 and SPA4 function...
Chen H, Huang X, Gusmaroli G, Terzaghi W, Lau O, Yanagawa Y, et al
. Arabidopsis CULLIN4-damaged DNA binding protein 1 interacts with CONSTITUTIVELY PHOTOMORPHOGENIC1-SUPPRESSOR OF PHYA complexes to regulate photomorphogenesis and flowering time. Plant Cell. 2010;22:108-23 pubmed publisher
..Thus, a series of CUL4-DDB1-COP1-SPA E3 ligase complexes may mediate the repression of photomorphogenesis and, possibly, of flowering time. ..