SPA2

Summary

Gene Symbol: SPA2
Description: SPA1-related 2
Alias: SPA1-related 2, T22B4.90, T22B4_90, SPA1-related 2
Species: thale cress

Top Publications

  1. Zhu D, Maier A, Lee J, Laubinger S, Saijo Y, Wang H, et al. Biochemical characterization of Arabidopsis complexes containing CONSTITUTIVELY PHOTOMORPHOGENIC1 and SUPPRESSOR OF PHYA proteins in light control of plant development. Plant Cell. 2008;20:2307-23 pubmed publisher
    ..This study thus provides an in-depth biochemical view of the SPA-COP1 E3 ligase complexes and offers new insights into the molecular basis for their distinct roles in the light control of plant development. ..
  2. Rolauffs S, Fackendahl P, Sahm J, Fiene G, Hoecker U. Arabidopsis COP1 and SPA genes are essential for plant elongation but not for acceleration of flowering time in response to a low red light to far-red light ratio. Plant Physiol. 2012;160:2015-27 pubmed publisher
    ..We propose that COP1/SPA activity, via LONG HYPOCOTYL IN FR LIGHT1, is required for shade-induced modulation of the auxin biosynthesis pathway and thereby enhances cell elongation in low R:FR. ..
  3. Chen H, Huang X, Gusmaroli G, Terzaghi W, Lau O, Yanagawa Y, et al. Arabidopsis CULLIN4-damaged DNA binding protein 1 interacts with CONSTITUTIVELY PHOTOMORPHOGENIC1-SUPPRESSOR OF PHYA complexes to regulate photomorphogenesis and flowering time. Plant Cell. 2010;22:108-23 pubmed publisher
    ..Thus, a series of CUL4-DDB1-COP1-SPA E3 ligase complexes may mediate the repression of photomorphogenesis and, possibly, of flowering time. ..
  4. Balcerowicz M, Fittinghoff K, Wirthmueller L, Maier A, Fackendahl P, Fiene G, et al. Light exposure of Arabidopsis seedlings causes rapid de-stabilization as well as selective post-translational inactivation of the repressor of photomorphogenesis SPA2. Plant J. 2011;65:712-23 pubmed publisher
    ..In particular, SPA1 and SPA2 differ in that SPA1 encodes a potent repressor in light- and dark-grown seedlings, but SPA2 fully loses its ..
  5. Maier A, Schrader A, Kokkelink L, Falke C, Welter B, Iniesto E, et al. Light and the E3 ubiquitin ligase COP1/SPA control the protein stability of the MYB transcription factors PAP1 and PAP2 involved in anthocyanin accumulation in Arabidopsis. Plant J. 2013;74:638-51 pubmed publisher
    ..Thus, our findings have identified mechanisms via which the COP1/SPA complex controls anthocyanin levels in Arabidopsis that may be useful for applications in biotechnology directed towards increasing anthocyanin content in plants. ..
  6. Heijde M, Binkert M, Yin R, Ares Orpel F, Rizzini L, Van De Slijke E, et al. Constitutively active UVR8 photoreceptor variant in Arabidopsis. Proc Natl Acad Sci U S A. 2013;110:20326-31 pubmed publisher
    ..We conclude that UVR8(W285A) is a constitutively active UVR8 photoreceptor variant in Arabidopsis, as is consistent with the crucial importance of monomer formation and COP1 binding for UVR8 activity. ..
  7. Laubinger S, Marchal V, Le Gourrierec J, Gentilhomme J, Wenkel S, Adrian J, et al. Arabidopsis SPA proteins regulate photoperiodic flowering and interact with the floral inducer CONSTANS to regulate its stability. Development. 2006;133:3213-22 pubmed
    ..Taken together, our results suggest, that SPA proteins regulate photoperiodic flowering by controlling the stability of the floral inducer CO. ..
  8. Chen S, Wirthmueller L, Stauber J, Lory N, Holtkotte X, Leson L, et al. The functional divergence between SPA1 and SPA2 in Arabidopsis photomorphogenesis maps primarily to the respective N-terminal kinase-like domain. BMC Plant Biol. 2016;16:165 pubmed publisher
    ..In particular, SPA1 and SPA2 strongly differ in their responsiveness to light, while they have indistinguishable activities in darkness...
  9. Chen S, Lory N, Stauber J, Hoecker U. Photoreceptor Specificity in the Light-Induced and COP1-Mediated Rapid Degradation of the Repressor of Photomorphogenesis SPA2 in Arabidopsis. PLoS Genet. 2015;11:e1005516 pubmed publisher
    ..Genetic analysis indicated that COP1/SPA2 function is particularly strongly repressed by light when compared to complexes carrying the other three SPAs, ..

More Information

Publications10

  1. Balcerowicz M, Kerner K, Schenkel C, Hoecker U. SPA Proteins Affect the Subcellular Localization of COP1 in the COP1/SPA Ubiquitin Ligase Complex during Photomorphogenesis. Plant Physiol. 2017;174:1314-1321 pubmed publisher