Gene Symbol: SNRK2.3
Description: sucrose nonfermenting 1(SNF1)-related protein kinase 2.3
Alias: SNRK2-3, SRK2I, SUCROSE NONFERMENTING 1 (SNF1)-RELATED PROTEIN KINASE 2-3, sucrose nonfermenting 1(SNF1)-related protein kinase 2.3, sucrose nonfermenting 1(SNF1)-related protein kinase 2.3
Species: thale cress

Top Publications

  1. Nakashima K, Fujita Y, Kanamori N, Katagiri T, Umezawa T, Kidokoro S, et al. Three Arabidopsis SnRK2 protein kinases, SRK2D/SnRK2.2, SRK2E/SnRK2.6/OST1 and SRK2I/SnRK2.3, involved in ABA signaling are essential for the control of seed development and dormancy. Plant Cell Physiol. 2009;50:1345-63 pubmed publisher
    ..SRK2D/SnRK2.2, SRK2E/SnRK2.6/OST1 and SRK2I/SnRK2.3 are redundant ABA-activated SNF1-related protein kinases 2 (SnRK2s) in Arabidopsis thaliana...
  2. Fujii H, Verslues P, Zhu J. Identification of two protein kinases required for abscisic acid regulation of seed germination, root growth, and gene expression in Arabidopsis. Plant Cell. 2007;19:485-94 pubmed
    ..Together, these results demonstrate that SnRK2.2 and SnRK2.3 are redundant but key protein kinases that mediate a major part of ABA signaling in Arabidopsis. ..
  3. Li J, Wang X, Watson M, Assmann S. Regulation of abscisic acid-induced stomatal closure and anion channels by guard cell AAPK kinase. Science. 2000;287:300-3 pubmed
    ..This information should allow cell-specific, targeted biotechnological manipulation of crop water status. ..
  4. West G, Pascal B, Ng L, Soon F, Melcher K, Xu H, et al. Protein conformation ensembles monitored by HDX reveal a structural rationale for abscisic acid signaling protein affinities and activities. Structure. 2013;21:229-35 pubmed publisher
    ..Furthermore, kinase activity is linked to a more stable "closed" conformation. These solution-based studies complement the static crystal structures and provide a more detailed understanding of the ABA signaling pathway. ..
  5. Cai Z, Liu J, Wang H, Yang C, Chen Y, Li Y, et al. GSK3-like kinases positively modulate abscisic acid signaling through phosphorylating subgroup III SnRK2s in Arabidopsis. Proc Natl Acad Sci U S A. 2014;111:9651-6 pubmed publisher
    ..2 and SnRK2.3. These findings provide significant insight into the modulation of ABA signaling by Arabidopsis GSK3-like kinases. ..
  6. Umezawa T, Sugiyama N, Mizoguchi M, Hayashi S, Myouga F, Yamaguchi Shinozaki K, et al. Type 2C protein phosphatases directly regulate abscisic acid-activated protein kinases in Arabidopsis. Proc Natl Acad Sci U S A. 2009;106:17588-93 pubmed publisher
    ..Our results demonstrate that group A PP2Cs act as 'gatekeepers' of subclass III SnRK2s, unraveling an important regulatory mechanism of ABA signaling. ..
  7. Feng C, Chen Y, Wang C, Kong Y, Wu W, Chen Y. Arabidopsis RAV1 transcription factor, phosphorylated by SnRK2 kinases, regulates the expression of ABI3, ABI4, and ABI5 during seed germination and early seedling development. Plant J. 2014;80:654-68 pubmed publisher
    ..Together, these results demonstrated that the Arabidopsis RAV1 transcription factor plays an important role in ABA signaling by modulating the expression of ABI3, ABI4, and ABI5, and that its activity is negatively affected by SnRK2s. ..
  8. Boudsocq M, Barbier Brygoo H, Laurière C. Identification of nine sucrose nonfermenting 1-related protein kinases 2 activated by hyperosmotic and saline stresses in Arabidopsis thaliana. J Biol Chem. 2004;279:41758-66 pubmed
    ..The probable involvement of the different Arabidopsis SnRK2 in several abiotic transduction pathways is discussed. ..
  9. Nishimura N, Sarkeshik A, Nito K, Park S, Wang A, Carvalho P, et al. PYR/PYL/RCAR family members are major in-vivo ABI1 protein phosphatase 2C-interacting proteins in Arabidopsis. Plant J. 2010;61:290-9 pubmed publisher

More Information


  1. Mogami J, Fujita Y, Yoshida T, Tsukiori Y, Nakagami H, Nomura Y, et al. Two distinct families of protein kinases are required for plant growth under high external Mg2+ concentrations in Arabidopsis. Plant Physiol. 2015;167:1039-57 pubmed publisher
    ..These results suggested that SRK2D/E/I- and CIPK26/3/9/23-mediated phosphorylation signaling pathways maintain cellular Mg(2+) homeostasis. ..
  2. Piskurewicz U, Jikumaru Y, Kinoshita N, Nambara E, Kamiya Y, Lopez Molina L. The gibberellic acid signaling repressor RGL2 inhibits Arabidopsis seed germination by stimulating abscisic acid synthesis and ABI5 activity. Plant Cell. 2008;20:2729-45 pubmed publisher
    ..These data support the notion that ABI5 acts as the final common repressor of germination in response to changes in ABA and GA levels. ..
  3. Zhou X, Soon F, Ng L, Kovach A, Suino Powell K, Li J, et al. Catalytic mechanism and kinase interactions of ABA-signaling PP2C phosphatases. Plant Signal Behav. 2012;7:581-8 pubmed publisher
    ..6-HAB1 complex, we present the catalytic mechanism of PP2C and provide new insight into PP2C-SnRK2 interactions and possible roles of other SnRK2 kinases in ABA signaling. ..
  4. Wang P, Zhu J, Lang Z. Nitric oxide suppresses the inhibitory effect of abscisic acid on seed germination by S-nitrosylation of SnRK2 proteins. Plant Signal Behav. 2015;10:e1031939 pubmed publisher
    ..Our results suggest that NO negatively regulates ABA signaling in germination and early seedling growth through S-nitrosylation of SnRK2.2 and SnRK2.3. ..
  5. Lynch T, Erickson B, Finkelstein R. Direct interactions of ABA-insensitive(ABI)-clade protein phosphatase(PP)2Cs with calcium-dependent protein kinases and ABA response element-binding bZIPs may contribute to turning off ABA response. Plant Mol Biol. 2012;80:647-58 pubmed publisher
    ..These studies support specific interactions among kinases, phosphatases and transcription factors that are co-expressed in early seedling development. ..
  6. Cheng C, Wang Z, Ren Z, Zhi L, Yao B, Su C, et al. SCFAtPP2-B11 modulates ABA signaling by facilitating SnRK2.3 degradation in Arabidopsis thaliana. PLoS Genet. 2017;13:e1006947 pubmed publisher
    ..3 overexpression lines. These results reveal a novel mechanism through which AtPP2-B11 specifically degrades SnRK2.3 to attenuate ABA signaling and the abiotic stress response in Arabidopsis. ..
  7. Soon F, Ng L, Zhou X, West G, Kovach A, Tan M, et al. Molecular mimicry regulates ABA signaling by SnRK2 kinases and PP2C phosphatases. Science. 2012;335:85-8 pubmed publisher
    ..These structural results provide a simple mechanism that directly couples ABA binding to SnRK2 kinase activation and highlight a new paradigm of kinase-phosphatase regulation through mutual packing of their catalytic sites. ..
  8. Fujii H, Chinnusamy V, Rodrigues A, Rubio S, Antoni R, Park S, et al. In vitro reconstitution of an abscisic acid signalling pathway. Nature. 2009;462:660-4 pubmed publisher
    ..Our results reveal new insights into ABA signalling mechanisms and define a minimal set of core components of a complete major ABA signalling pathway...
  9. Fujii H, Verslues P, Zhu J. Arabidopsis decuple mutant reveals the importance of SnRK2 kinases in osmotic stress responses in vivo. Proc Natl Acad Sci U S A. 2011;108:1717-22 pubmed publisher
    ..These results demonstrate critical functions of the SnRK2s in mediating osmotic stress signaling and tolerance. ..
  10. Ding Y, Li H, Zhang X, Xie Q, Gong Z, Yang S. OST1 kinase modulates freezing tolerance by enhancing ICE1 stability in Arabidopsis. Dev Cell. 2015;32:278-89 pubmed publisher
    ..Our results thus uncover the unexpected roles of OST1 in modulating CBF-dependent cold signaling in Arabidopsis. ..
  11. Fujita Y, Nakashima K, Yoshida T, Katagiri T, Kidokoro S, Kanamori N, et al. Three SnRK2 protein kinases are the main positive regulators of abscisic acid signaling in response to water stress in Arabidopsis. Plant Cell Physiol. 2009;50:2123-32 pubmed publisher
    ..2, SRK2E/SnRK2.6 and SRK2I/SnRK2.3 (SRK2D/E/I)...