Gene Symbol: SLEEPY1
Description: F-box family protein
Alias: SLEEPY1, T22A6.40, T22A6_40, F-box family protein
Species: thale cress
Products:     SLEEPY1

Top Publications

  1. Nakajima M, Shimada A, Takashi Y, Kim Y, Park S, Ueguchi Tanaka M, et al. Identification and characterization of Arabidopsis gibberellin receptors. Plant J. 2006;46:880-9 pubmed
    ..The expression of each AtGID1 clone in the rice gid1-1 mutant rescued the GA-insensitive dwarf phenotype. These results demonstrate that all three AtGID1s functioned as GA receptors in Arabidopsis. ..
  2. McGinnis K, Thomas S, Soule J, Strader L, Zale J, Sun T, et al. The Arabidopsis SLEEPY1 gene encodes a putative F-box subunit of an SCF E3 ubiquitin ligase. Plant Cell. 2003;15:1120-30 pubmed
    The Arabidopsis SLY1 (SLEEPY1) gene positively regulates gibberellin (GA) signaling. Positional cloning of SLY1 revealed that it encodes a putative F-box protein...
  3. Griffiths J, Murase K, Rieu I, Zentella R, Zhang Z, Powers S, et al. Genetic characterization and functional analysis of the GID1 gibberellin receptors in Arabidopsis. Plant Cell. 2006;18:3399-414 pubmed
    ..Furthermore, yeast three-hybrid assays showed that the GA-GID1 complex promotes the interaction between RGA and the F-box protein SLY1, a component of the SCF(SLY1) E3 ubiquitin ligase that targets the DELLA protein for degradation. ..
  4. Ariizumi T, Lawrence P, Steber C. The role of two f-box proteins, SLEEPY1 and SNEEZY, in Arabidopsis gibberellin signaling. Plant Physiol. 2011;155:765-75 pubmed publisher
    The SLEEPY1 (SLY1) F-box gene is a positive regulator of gibberellin (GA) signaling in Arabidopsis (Arabidopsis thaliana)...
  5. Dill A, Thomas S, Hu J, Steber C, Sun T. The Arabidopsis F-box protein SLEEPY1 targets gibberellin signaling repressors for gibberellin-induced degradation. Plant Cell. 2004;16:1392-405 pubmed
    ..b>SLEEPY1 (SLY1) encodes an F-box-containing protein, and the loss-of-function sly1 mutant has a GA-insensitive dwarf ..
  6. Fu X, Richards D, Fleck B, Xie D, Burton N, Harberd N. The Arabidopsis mutant sleepy1gar2-1 protein promotes plant growth by increasing the affinity of the SCFSLY1 E3 ubiquitin ligase for DELLA protein substrates. Plant Cell. 2004;16:1406-18 pubmed
    ..Growth-promoting DELLA destruction is dependent on SLY1 availability, on the strength of the interaction between SLY1 and the DELLA target, and on promotion of the SCFSLY1-DELLA interaction by DELLA phosphorylation. ..
  7. Ariizumi T, Murase K, Sun T, Steber C. Proteolysis-independent downregulation of DELLA repression in Arabidopsis by the gibberellin receptor GIBBERELLIN INSENSITIVE DWARF1. Plant Cell. 2008;20:2447-59 pubmed publisher
    ..biosynthesis, three functionally redundant GA receptors GIBBERELLIN INSENSITIVE DWARF1 (GID1a, b, and c), and the SLEEPY1 (SLY1) F-box subunit of an SCF E3 ubiquitin ligase...
  8. Ariizumi T, Steber C. Seed germination of GA-insensitive sleepy1 mutants does not require RGL2 protein disappearance in Arabidopsis. Plant Cell. 2007;19:791-804 pubmed
    We explore the roles of gibberellin (GA) signaling genes SLEEPY1 (SLY1) and RGA-LIKE2 (RGL2) in regulation of seed germination in Arabidopsis thaliana, a plant in which the hormone GA is required for seed germination...
  9. Suzuki H, Park S, Okubo K, Kitamura J, Ueguchi Tanaka M, Iuchi S, et al. Differential expression and affinities of Arabidopsis gibberellin receptors can explain variation in phenotypes of multiple knock-out mutants. Plant J. 2009;60:48-55 pubmed publisher

More Information


  1. Kim S, Park B, Kim D, Yeu S, Song S, Song J, et al. E3 SUMO ligase AtSIZ1 positively regulates SLY1-mediated GA signalling and plant development. Biochem J. 2015;469:299-314 pubmed publisher to DELLA protein degradation; the regulatory mechanisms controlling how the stability and function of SLEEPY1 (SLY1), a protein that interacts with target DELLA proteins as components of the Skp, Cullin, F-box (SCF)(SLY1) ..
  2. Sheerin D, Buchanan J, Kirk C, Harvey D, Sun X, Spagnuolo J, et al. Inter- and intra-molecular interactions of Arabidopsis thaliana DELLA protein RGL1. Biochem J. 2011;435:629-39 pubmed publisher
    ..thaliana with the gibberellin receptor GID1A (GIBBERELLIC ACID-INSENSITIVE DWARF-1A) and the F-box protein SLY1 (SLEEPY1)...
  3. Hauvermale A, Ariizumi T, Steber C. The roles of the GA receptors GID1a, GID1b, and GID1c in sly1-independent GA signaling. Plant Signal Behav. 2014;9:e28030 pubmed
    ..In proteolytic GA signaling, the SLEEPY1 (SLY1) F-box protein targets DELLA proteins in the GID1-GA-DELLA complex for destruction through the ubiquitin-..