Gene Symbol: SKP1
Description: S phase kinase-associated protein 1
Alias: ARABIDOPSIS SKP1 HOMOLOGUE 1, ASK1, ATSKP1, S phase kinase-associated protein 1, SKP1A, T4O12.17, T4O12_17, UFO INTERACTING PROTEIN 1, UIP1, S phase kinase-associated protein 1
Species: thale cress
Products:     SKP1

Top Publications

  1. Marrocco K, Zhou Y, Bury E, Dieterle M, Funk M, Genschik P, et al. Functional analysis of EID1, an F-box protein involved in phytochrome A-dependent light signal transduction. Plant J. 2006;45:423-38 pubmed
    ..EID1 interacts specifically with several Arabidopsis Skp1-like (ASK) proteins and Cullin1 to form stable dimeric and trimeric complexes...
  2. Tan X, Calderon Villalobos L, Sharon M, Zheng C, Robinson C, Estelle M, et al. Mechanism of auxin perception by the TIR1 ubiquitin ligase. Nature. 2007;446:640-5 pubmed
    ..Here we present the crystal structures of the Arabidopsis TIR1-ASK1 complex, free and in complexes with three different auxin compounds and an Aux/IAA substrate peptide...
  3. Kong H, Landherr L, Frohlich M, Leebens Mack J, Ma H, dePamphilis C. Patterns of gene duplication in the plant SKP1 gene family in angiosperms: evidence for multiple mechanisms of rapid gene birth. Plant J. 2007;50:873-85 pubmed
    ..Here we show that plant SKP1 genes have evolved by multiple duplication events from a single ancestral copy in the most recent common ancestor (..
  4. Stolpe T, Süsslin C, Marrocco K, Nick P, Kretsch T, Kircher S. In planta analysis of protein-protein interactions related to light signaling by bimolecular fluorescence complementation. Protoplasma. 2005;226:137-46 pubmed
    ..the F-box protein EID1 (empfindlicher im dunkelroten Licht 1) and the Arabidopsis S-phase kinase-related protein 1 (ASK1). The interaction of both proteins was specific and strictly dependent on the presence of an intact F-box domain...
  5. Zhao D, Yang X, Quan L, Timofejeva L, Rigel N, Ma H, et al. ASK1, a SKP1 homolog, is required for nuclear reorganization, presynaptic homolog juxtaposition and the proper distribution of cohesin during meiosis in Arabidopsis. Plant Mol Biol. 2006;62:99-110 pubmed
    ..demonstrate that nuclear reorganization and homolog juxtapositioning processes are defective in a null mutant, ask1-1...
  6. Díaz Camino C, Risseeuw E, Liu E, Crosby W. A high-throughput system for two-hybrid screening based on growth curve analysis in microtiter plates. Anal Biochem. 2003;316:171-4 pubmed
  7. Takahashi N, Kuroda H, Kuromori T, Hirayama T, Seki M, Shinozaki K, et al. Expression and interaction analysis of Arabidopsis Skp1-related genes. Plant Cell Physiol. 2004;45:83-91 pubmed
    ..of such proteolysis is regulated by protein polyubiquitination that is promoted by the SCF complex consisting of Skp1, cullin, and an F-box protein. We examined the activities of the Arabidopsis Skp1-related proteins (ASKs)...
  8. Sheard L, Tan X, Mao H, Withers J, Ben Nissan G, Hinds T, et al. Jasmonate perception by inositol-phosphate-potentiated COI1-JAZ co-receptor. Nature. 2010;468:400-5 pubmed publisher
    ..Our results unravel the mechanism of jasmonate perception and highlight the ability of F-box proteins to evolve as multi-component signalling hubs...
  9. Devoto A, Nieto Rostro M, Xie D, Ellis C, Harmston R, Patrick E, et al. COI1 links jasmonate signalling and fertility to the SCF ubiquitin-ligase complex in Arabidopsis. Plant J. 2002;32:457-66 pubmed
    ..Significantly, each of these responses requires COI1, an F-box protein. Other F-box proteins interact with SKP1 and cullin proteins to form SCF complexes that selectively recruit regulatory proteins targeted for ubiquitination...

More Information


  1. Dharmasiri N, Dharmasiri S, Weijers D, Lechner E, Yamada M, Hobbie L, et al. Plant development is regulated by a family of auxin receptor F box proteins. Dev Cell. 2005;9:109-19 pubmed
    ..Correspondingly, all TIR1/AFB proteins interact with BDL, and BDL is stabilized in triple mutant plants. Our results indicate that TIR1 and the AFB proteins collectively mediate auxin responses throughout plant development. ..
  2. Wang Y, Yang M. The ARABIDOPSIS SKP1-LIKE1 (ASK1) protein acts predominately from leptotene to pachytene and represses homologous recombination in male meiosis. Planta. 2006;223:613-7 pubmed
    ..The ARABIDOPSIS SKP1-LIKE1 (ASK1) protein is a component of the Skp1-Cullin-F-box-protein (SCF) ubiquitin ligases that target a variety of proteins ..
  3. Harmon F, Kay S. The F box protein AFR is a positive regulator of phytochrome A-mediated light signaling. Curr Biol. 2003;13:2091-6 pubmed
    ..Furthermore, AFR is a true SCF E3 ubiquitin ligase component. SCF(AFR) is expected to mediate the turnover of a repressor of phyA signaling, possibly to prepare the plant to receive light signals at dawn. ..
  4. Gagne J, Downes B, Shiu S, Durski A, Vierstra R. The F-box subunit of the SCF E3 complex is encoded by a diverse superfamily of genes in Arabidopsis. Proc Natl Acad Sci U S A. 2002;99:11519-24 pubmed
    ..One ligase type, the SCF E3s are composed of four proteins, cullin1/Cdc53, Rbx1/Roc1/Hrt1, Skp1, and an F-box protein...
  5. Jurado S, Diaz Trivino S, Abraham Z, Manzano C, Gutierrez C, Del Pozo C. SKP2A, an F-box protein that regulates cell division, is degraded via the ubiquitin pathway. Plant J. 2008;53:828-41 pubmed
    ..Taken together, our results indicate that SKP2A is a positive regulator of cell division, and its stability is controlled by auxin-dependent degradation. ..
  6. Dieterle M, Zhou Y, Schafer E, Funk M, Kretsch T. EID1, an F-box protein involved in phytochrome A-specific light signaling. Genes Dev. 2001;15:939-44 pubmed
    ..EID1 most probably acts by targeting activated components of the phyA signaling pathway to ubiquitin-dependent proteolysis. ..
  7. Ren C, Pan J, Peng W, Genschik P, Hobbie L, Hellmann H, et al. Point mutations in Arabidopsis Cullin1 reveal its essential role in jasmonate response. Plant J. 2005;42:514-24 pubmed
    The SKP1-Cullin/Cdc53-F-box protein ubiquitin ligases (SCF) target many important regulatory proteins for degradation and play vital roles in diverse cellular processes. In Arabidopsis there are 11 Cullin members (AtCUL)...
  8. Durfee T, Roe J, Sessions R, Inouye C, Serikawa K, Feldmann K, et al. The F-box-containing protein UFO and AGAMOUS participate in antagonistic pathways governing early petal development in Arabidopsis. Proc Natl Acad Sci U S A. 2003;100:8571-6 pubmed
    ..gene encodes an F-box-containing protein, UFO, which interacts physically and genetically with the Skp1 homolog, ASK1. In this report, we describe four ufo alleles characterized by the absence of petals, which uncover another role ..
  9. Dieterle M, Thomann A, Renou J, Parmentier Y, Cognat V, Lemonnier G, et al. Molecular and functional characterization of Arabidopsis Cullin 3A. Plant J. 2005;41:386-99 pubmed
    ..The viability of the mutant plants suggests functional redundancy between the two CUL3 genes in Arabidopsis. ..
  10. Maldonado Calderón M, Sepúlveda García E, Rocha Sosa M. Characterization of novel F-box proteins in plants induced by biotic and abiotic stress. Plant Sci. 2012;185-186:208-17 pubmed publisher
    ..A yeast two-hybrid assay proved that AtFBS1 was able to interact with ASK1, the component of the SCF complex that binds the F-box...
  11. Moon J, Zhao Y, Dai X, Zhang W, Gray W, Huq E, et al. A new CULLIN 1 mutant has altered responses to hormones and light in Arabidopsis. Plant Physiol. 2007;143:684-96 pubmed
    ..Characterization of weak cul1 mutants provides insight into the role of SCFs throughout plant growth and development. ..
  12. Xu L, Liu F, Lechner E, Genschik P, Crosby W, Ma H, et al. The SCF(COI1) ubiquitin-ligase complexes are required for jasmonate response in Arabidopsis. Plant Cell. 2002;14:1919-35 pubmed
    ..In this study, we demonstrate that COI1 associates physically with AtCUL1, AtRbx1, and either of the Arabidopsis Skp1-like proteins ASK1 or ASK2 to assemble ubiquitin-ligase complexes, which we have designated SCF(COI1)...
  13. Zhu J, Li Y, Cao D, Yang H, Oh E, Bi Y, et al. The F-box Protein KIB1 Mediates Brassinosteroid-Induced Inactivation and Degradation of GSK3-like Kinases in Arabidopsis. Mol Cell. 2017;66:648-657.e4 pubmed publisher
    ..Our study demonstrates that KIB1 plays an essential role in BR signaling by inhibiting BIN2 through dual mechanisms of blocking substrate access and promoting degradation. ..
  14. Gingerich D, Gagne J, Salter D, Hellmann H, Estelle M, Ma L, et al. Cullins 3a and 3b assemble with members of the broad complex/tramtrack/bric-a-brac (BTB) protein family to form essential ubiquitin-protein ligases (E3s) in Arabidopsis. J Biol Chem. 2005;280:18810-21 pubmed
    ..Arabidopsis defective in both CUL3a and CUL3b are embryo-lethal, indicating that BTB E3s are essential for plant development. ..
  15. Li C, Liu Z, Zhang Q, Wang R, Xiao L, Ma H, et al. SKP1 is involved in abscisic acid signalling to regulate seed germination, stomatal opening and root growth in Arabidopsis thaliana. Plant Cell Environ. 2012;35:952-65 pubmed publisher
    ..Plant SKP1 proteins are subunits of the SCF complex E3 ligases, which regulate several phytohormone signalling pathways ..
  16. Tzfira T, Vaidya M, Citovsky V. Involvement of targeted proteolysis in plant genetic transformation by Agrobacterium. Nature. 2004;431:87-92 pubmed publisher
    ..These results suggest that VIP1 and its cognate VirE2 are specifically targeted by the VirF-containing Skp1-Cdc53-cullin-F-box complex for proteolysis...
  17. Yang M, Hu Y, Lodhi M, McCombie W, Ma H. The Arabidopsis SKP1-LIKE1 gene is essential for male meiosis and may control homologue separation. Proc Natl Acad Sci U S A. 1999;96:11416-21 pubmed
    ..Nine Arabidopsis SKP1 homologues have been uncovered and are named ASK1 through ASK9...
  18. Anand A, Rojas C, Tang Y, Mysore K. Several components of SKP1/Cullin/F-box E3 ubiquitin ligase complex and associated factors play a role in Agrobacterium-mediated plant transformation. New Phytol. 2012;195:203-16 pubmed publisher
    ..studies suggested that the Arabidopsis homologs of yeast SKP1 (suppressor of kinetochore protein 1) protein, ASK1 and ASK2, are required for Agrobacterium-mediated plant transformation...
  19. Song Y, Estrada D, Johnson R, Kim S, Lee S, MacCoss M, et al. Distinct roles of FKF1, Gigantea, and Zeitlupe proteins in the regulation of Constans stability in Arabidopsis photoperiodic flowering. Proc Natl Acad Sci U S A. 2014;111:17672-7 pubmed publisher
    ..kinase-associated protein 1 (Skp1)/Cullin(CUL)/F-box complex through interactions with Arabidopsis Skp1-like 1 (ASK1), ASK2, and CUL1 proteins and mainly interacts with GI protein in vivo...
  20. Lu D, Ni W, Stanley B, Ma H. Proteomics and transcriptomics analyses of Arabidopsis floral buds uncover important functions of ARABIDOPSIS SKP1-LIKE1. BMC Plant Biol. 2016;16:61 pubmed publisher
    The ARABIDOPSIS SKP1-LIKE1 (ASK1) protein functions as a subunit of SKP1-CUL1-F-box (SCF) E3 ubiquitin ligases. Previous genetic studies showed that ASK1 plays important roles in Arabidopsis flower development and male meiosis...
  21. Kim O, Jung J, Park C. An Arabidopsis F-box protein regulates tapetum degeneration and pollen maturation during anther development. Planta. 2010;232:353-66 pubmed publisher
    ..It physically interacts with the Arabidopsis-Skp1-like1 protein via the F-box motif...
  22. Yang X, Timofejeva L, Ma H, Makaroff C. The Arabidopsis SKP1 homolog ASK1 controls meiotic chromosome remodeling and release of chromatin from the nuclear membrane and nucleolus. J Cell Sci. 2006;119:3754-63 pubmed
    ..electron microscopy and immunolocalization studies with antibodies to modified histones, we demonstrate that ASK1 is essential for early nuclear reorganization events...
  23. Fu X, Richards D, Fleck B, Xie D, Burton N, Harberd N. The Arabidopsis mutant sleepy1gar2-1 protein promotes plant growth by increasing the affinity of the SCFSLY1 E3 ubiquitin ligase for DELLA protein substrates. Plant Cell. 2004;16:1406-18 pubmed
    ..Growth-promoting DELLA destruction is dependent on SLY1 availability, on the strength of the interaction between SLY1 and the DELLA target, and on promotion of the SCFSLY1-DELLA interaction by DELLA phosphorylation. ..
  24. Wang X, Ni W, Ge X, Zhang J, Ma H, Cao K. Proteomic identification of potential target proteins regulated by an ASK1-mediated proteolysis pathway. Cell Res. 2006;16:489-98 pubmed
    The ASK1 (ARABIDOPSIS SKP1-LIKE) protein is a critical component of the SCF (Skp1-Cullin-F box protein) ubiquitin ligase complexes that recruit target proteins for degradation by the 26S proteosome...
  25. Quint M, Ito H, Zhang W, Gray W. Characterization of a novel temperature-sensitive allele of the CUL1/AXR6 subunit of SCF ubiquitin-ligases. Plant J. 2005;43:371-83 pubmed
    ..The axr6-3 mutation interferes with Skp1 binding, thus preventing SCF complex assembly...
  26. Dezfulian M, Soulliere D, Dhaliwal R, Sareen M, Crosby W. The SKP1-like gene family of Arabidopsis exhibits a high degree of differential gene expression and gene product interaction during development. PLoS ONE. 2012;7:e50984 pubmed publisher
    ..One such gene family encodes the Skp1-like class of polypeptide subunits, where 21 genes have been identified and are known to be expressed in ..
  27. Kevei E, Gyula P, Hall A, Kozma Bognar L, Kim W, Eriksson M, et al. Forward genetic analysis of the circadian clock separates the multiple functions of ZEITLUPE. Plant Physiol. 2006;140:933-45 pubmed
    ..Forward genetics continues to provide insight regarding both known and newly discovered components of the circadian system, although current approaches have saturated mutations at some loci. ..
  28. Gray W, del Pozo J, Walker L, Hobbie L, Risseeuw E, Banks T, et al. Identification of an SCF ubiquitin-ligase complex required for auxin response in Arabidopsis thaliana. Genes Dev. 1999;13:1678-91 pubmed
    ..Mutations in either ASK1 or TIR1 result in decreased auxin response...
  29. Bao Y, Song W, Jin Y, Jiang C, Yang Y, Li B, et al. Characterization of Arabidopsis Tubby-like proteins and redundant function of AtTLP3 and AtTLP9 in plant response to ABA and osmotic stress. Plant Mol Biol. 2014;86:471-83 pubmed publisher
    ..PM) tethering, plant TLPs also possess an amino (N)-terminal F-box domain to interact with specific Arabidopsis Skp1-like (ASK) proteins as functional SCF-type E3 ligases...
  30. Farras R, Ferrando A, Jasik J, Kleinow T, Okrész L, Tiburcio A, et al. SKP1-SnRK protein kinase interactions mediate proteasomal binding of a plant SCF ubiquitin ligase. EMBO J. 2001;20:2742-56 pubmed
    ..Here we show that SKP1/ASK1, a conserved SCF (Skp1-cullin-F-box) ubiquitin ligase subunit, which suppresses the skp1-4 mitotic defect in yeast, ..
  31. Lai C, Lee C, Chen P, Wu S, Yang C, Shaw J. Molecular analyses of the Arabidopsis TUBBY-like protein gene family. Plant Physiol. 2004;134:1586-97 pubmed
    ..The interaction between AtTLP9 and ASK1 (Arabidopsis Skp1-like 1) is confirmed via yeast (Saccharomyces cerevisiae) two-hybrid assays...
  32. Zaltsman A, Krichevsky A, Loyter A, Citovsky V. Agrobacterium induces expression of a host F-box protein required for tumorigenicity. Cell Host Microbe. 2010;7:197-209 pubmed publisher
    ..During this process, a Skp1-Cdc53-cullin-F-box (SCF) complex that contains the bacterial virulence F-box protein VirF facilitates genetic ..
  33. Stirnberg P, Furner I, Ottoline Leyser H. MAX2 participates in an SCF complex which acts locally at the node to suppress shoot branching. Plant J. 2007;50:80-94 pubmed
    ..Myc-epitope-tagged MAX2 interacts with the core SCF subunits ASK1 and AtCUL1 in planta...
  34. Koops P, Pelser S, Ignatz M, Klose C, Marrocco Selden K, Kretsch T. EDL3 is an F-box protein involved in the regulation of abscisic acid signalling in Arabidopsis thaliana. J Exp Bot. 2011;62:5547-60 pubmed publisher
    ..Thus, the protein is presumed to act as a component of a ubiquitin ligase complex that specifically directs negatively acting factors in ABA signalling to degradation via the proteasome. ..
  35. Pazhouhandeh M, Dieterle M, Marrocco K, Lechner E, Berry B, Brault V, et al. F-box-like domain in the polerovirus protein P0 is required for silencing suppressor function. Proc Natl Acad Sci U S A. 2006;103:1994-9 pubmed
    ..means of a conserved minimal F-box motif with Arabidopsis thaliana orthologs of S-phase kinase-related protein 1 (SKP1), a component of the SCF family of ubiquitin E3 ligases...
  36. Takahashi Y, Ebisu Y, Kinoshita T, Doi M, Okuma E, Murata Y, et al. bHLH transcription factors that facilitate K? uptake during stomatal opening are repressed by abscisic acid through phosphorylation. Sci Signal. 2013;6:ra48 pubmed publisher
  37. Serino G, Su H, Peng Z, Tsuge T, Wei N, Gu H, et al. Characterization of the last subunit of the Arabidopsis COP9 signalosome: implications for the overall structure and origin of the complex. Plant Cell. 2003;15:719-31 pubmed
    ..Comparative analyses of the subunit interaction of CSN revealed a set of conserved subunit contacts and resulted in a model of CSN subunit topology, some aspects of which were substantiated by in vivo cross-link tests. ..
  38. Potuschak T, Lechner E, Parmentier Y, Yanagisawa S, Grava S, Koncz C, et al. EIN3-dependent regulation of plant ethylene hormone signaling by two arabidopsis F box proteins: EBF1 and EBF2. Cell. 2003;115:679-89 pubmed
    ..Our work places EBF1 and EBF2 within the genetic framework of the ethylene-response pathway and supports a model in which ethylene action depends on EIN3 protein stabilization. ..
  39. Porat R, Lu P, O Neill S. Arabidopsis SKP1, a homologue of a cell cycle regulator gene, is predominantly expressed in meristematic cells. Planta. 1998;204:345-51 pubmed
    ..Heynh. cDNA designated ATskp1 that also has high sequence similarity to yeast SKP1...
  40. Gray W, Muskett P, Chuang H, Parker J. Arabidopsis SGT1b is required for SCF(TIR1)-mediated auxin response. Plant Cell. 2003;15:1310-9 pubmed
    ..We conclude that ETA3/SGT1b is required for the SCF(TIR1)-mediated degradation of Aux/IAA proteins. ..
  41. Andrade M, Gonzalez Guzman M, Serrano R, Rodriguez P. A combination of the F-box motif and kelch repeats defines a large Arabidopsis family of F-box proteins. Plant Mol Biol. 2001;46:603-14 pubmed
    ..was shown to be functionally active by its ability to mediate the in vitro interaction between At5g48990 and ASK1 proteins...
  42. Zhang W, Ito H, Quint M, Huang H, Noël L, Gray W. Genetic analysis of CAND1-CUL1 interactions in Arabidopsis supports a role for CAND1-mediated cycling of the SCFTIR1 complex. Proc Natl Acad Sci U S A. 2008;105:8470-5 pubmed publisher
    b>SKP1-Cullin1-F-box protein (SCF) ubiquitin-ligases regulate numerous aspects of eukaryotic growth and development. Cullin-Associated and Neddylation-Dissociated (CAND1) modulates SCF function through its interactions with the CUL1 subunit...
  43. Franciosini A, Lombardi B, Iafrate S, Pecce V, Mele G, Lupacchini L, et al. The Arabidopsis COP9 SIGNALOSOME INTERACTING F-BOX KELCH 1 protein forms an SCF ubiquitin ligase and regulates hypocotyl elongation. Mol Plant. 2013;6:1616-29 pubmed publisher
    ..We propose that CFK1 (and its regulation by CSN) is a novel component of the cellular mechanisms controlling hypocotyl elongation. ..
  44. Wang Z, Li N, Jiang S, Gonzalez N, Huang X, Wang Y, et al. SCF(SAP) controls organ size by targeting PPD proteins for degradation in Arabidopsis thaliana. Nat Commun. 2016;7:11192 pubmed publisher
    ..We show that SAP is an F-box protein that forms part of a SKP1/Cullin/F-box E3 ubiquitin ligase complex and controls organ size by promoting the proliferation of meristemoid ..
  45. Kim S, Park B, Kim D, Yeu S, Song S, Song J, et al. E3 SUMO ligase AtSIZ1 positively regulates SLY1-mediated GA signalling and plant development. Biochem J. 2015;469:299-314 pubmed publisher
    ..In addition, sumoylated SLY1 interacted with RGA and SLY1 sumoylation was significantly increased by GA. Taken together, our results indicate that, in Arabidopsis, AtSIZ1 positively controls GA signalling through SLY1 sumoylation. ..
  46. Schouten J, De Kam R, Fetter K, Hoge J. Overexpression of Arabidopsis thaliana SKP1 homologues in yeast inactivates the Mig1 repressor by destabilising the F-box protein Grr1. Mol Gen Genet. 2000;263:309-19 pubmed
    ..Recently, Skp1 from yeast (Saccharomyces cerevisiae) was shown to play an important role in the ubiquitin-mediated proteolysis of ..
  47. Hellmann H, Hobbie L, Chapman A, Dharmasiri S, Dharmasiri N, Del Pozo C, et al. Arabidopsis AXR6 encodes CUL1 implicating SCF E3 ligases in auxin regulation of embryogenesis. EMBO J. 2003;22:3314-25 pubmed
    ..In addition, we show that CUL1 has a role in auxin response throughout the life cycle of the plant. ..
  48. Pauwels L, Ritter A, Goossens J, Durand A, Liu H, Gu Y, et al. The RING E3 Ligase KEEP ON GOING Modulates JASMONATE ZIM-DOMAIN12 Stability. Plant Physiol. 2015;169:1405-17 pubmed publisher
    ..Our results provide additional evidence for KEG as an important factor in plant hormone signaling and a positive regulator of JAZ12 stability. ..
  49. Li Y, Zhang L, Li D, Liu Z, Wang J, Li X, et al. The Arabidopsis F-box E3 ligase RIFP1 plays a negative role in abscisic acid signalling by facilitating ABA receptor RCAR3 degradation. Plant Cell Environ. 2016;39:571-82 pubmed publisher
    ..F-BOX PROTEIN 1 (RIFP1) interacts with ABA receptor (RCAR3) and SCF E3 ligase complex subunits Arabidopsis SKP1-LIKE PROTEINs (ASKs) in vitro and in vivo...
  50. Jeong C, Roh H, Dang T, Choi Y, Fischer R, Lee J, et al. An E3 ligase complex regulates SET-domain polycomb group protein activity in Arabidopsis thaliana. Proc Natl Acad Sci U S A. 2011;108:8036-41 pubmed publisher
    ..Taken together, these results demonstrate the posttranslational regulation of the CLF SET-domain PcG activity by the UCL1 F-box protein in the E3 ligase complex. ..
  51. Schrammeijer B, Risseeuw E, Pansegrau W, Regensburg Tuïnk T, Crosby W, Hooykaas P. Interaction of the virulence protein VirF of Agrobacterium tumefaciens with plant homologs of the yeast Skp1 protein. Curr Biol. 2001;11:258-62 pubmed
    ..protein is the first prokaryotic protein with an F box by which it can interact with plant homologs of the yeast Skp1 protein. The presence of the F box turned out to be essential for the biological function of VirF...
  52. Dezfulian M, Jalili E, Roberto D, Moss B, Khoo K, Nemhauser J, et al. Oligomerization of SCFTIR1 Is Essential for Aux/IAA Degradation and Auxin Signaling in Arabidopsis. PLoS Genet. 2016;12:e1006301 pubmed publisher
    ..We propose oligomerization of TIR1 as a novel regulatory mechanism in the regulation of auxin-mediated plant patterning and development. ..
  53. Kim H, Chiang Y, Kieber J, Schaller G. SCF(KMD) controls cytokinin signaling by regulating the degradation of type-B response regulators. Proc Natl Acad Sci U S A. 2013;110:10028-33 pubmed publisher
    ..KMD proteins form an S-phase kinase-associated PROTEIN1 (SKP1)/Cullin/F-box protein (SCF) E3 ubiquitin ligase complex and directly interact with type-B ARR proteins...
  54. Wang X, Feng S, Nakayama N, Crosby W, Irish V, Deng X, et al. The COP9 signalosome interacts with SCF UFO and participates in Arabidopsis flower development. Plant Cell. 2003;15:1071-82 pubmed
    ..We conclude that CSN is an essential regulator of Arabidopsis flower development and suggest that CSN regulates Arabidopsis flower development in part by modulating SCF(UFO)-mediated AP3 activation. ..
  55. Kim H, Oh S, Brownfield L, Hong S, Ryu H, Hwang I, et al. Control of plant germline proliferation by SCF(FBL17) degradation of cell cycle inhibitors. Nature. 2008;455:1134-7 pubmed publisher
    ..We show that FBL17 is transiently expressed in the male germ line after asymmetric division and forms an SKP1-Cullin1-F-box protein (SCF) E3 ubiquitin ligase complex (SCF(FBL17)) that targets the cyclin-dependent kinase ..
  56. Gou M, Su N, Zheng J, Huai J, Wu G, Zhao J, et al. An F-box gene, CPR30, functions as a negative regulator of the defense response in Arabidopsis. Plant J. 2009;60:757-70 pubmed publisher
    ..As an F-box protein, CPR30 could interact with multiple Arabidopsis-SKP1-like (ASK) proteins in vivo. Co-localization of CPR30 and ASK1 or ASK2 was observed in Arabidopsis protoplasts...
  57. Yasuhara M, Mitsui S, Hirano H, Takanabe R, Tokioka Y, Ihara N, et al. Identification of ASK and clock-associated proteins as molecular partners of LKP2 (LOV kelch protein 2) in Arabidopsis. J Exp Bot. 2004;55:2015-27 pubmed
    ..Yeast two-hybrid analysis demonstrated that LKP2 interacted with some Arabidopsis Skp1-like proteins (ASK), as do other ADO/FKF/LKP/ZTL family proteins, suggesting that LKP2 can form an SCF (Skp1-Cullin-..
  58. Han L, Mason M, Risseeuw E, Crosby W, Somers D. Formation of an SCF(ZTL) complex is required for proper regulation of circadian timing. Plant J. 2004;40:291-301 pubmed
    ..Co-immunoprecipitation of full-length (FL) ZTL with the three known core components of SCF complexes (ASK1, AtCUL1 and AtRBX1) demonstrates that ZTL can assemble into an SCF complex in vivo...
  59. Thelander M, Fredriksson D, Schouten J, Hoge J, Ronne H. Cloning by pathway activation in yeast: identification of an Arabidopsis thaliana F-box protein that can turn on glucose repression. Plant Mol Biol. 2002;49:69-79 pubmed
    ..Two-hybrid experiments revealed that AtGRH1 can interact with AtSKP1a and AtSKP1b, two recently identified SKP1 homologues in Arabidopsis...
  60. Dai L, Xu L, Huang D, Li X, Luo K, Guan C. ASK1 physically interacts with COI1 and is required for male fertility in Arabidopsis. Sci China C Life Sci. 2002;45:631-6 pubmed publisher
    ..We demonstrated for the first time that COI1 interacts with the Arabidopsis SKP1-LIKE1 (ASK1) to form a complex that is required for jasmonate action in planta...
  61. Chuang H, Zhang W, Gray W. Arabidopsis ETA2, an apparent ortholog of the human cullin-interacting protein CAND1, is required for auxin responses mediated by the SCF(TIR1) ubiquitin ligase. Plant Cell. 2004;16:1883-97 pubmed
    ..Our genetic and molecular analysis of SCF(TIR1) function in eta2 mutants provides novel insight into the role of CAND1 in the regulation of SCF ubiquitin-ligase activity. ..
  62. Samach A, Klenz J, Kohalmi S, Risseeuw E, Haughn G, Crosby W. The UNUSUAL FLORAL ORGANS gene of Arabidopsis thaliana is an F-box protein required for normal patterning and growth in the floral meristem. Plant J. 1999;20:433-45 pubmed
    ..mode of action of the UFO gene product, we show here that UFO is an F-box protein that interacts with Arabidopsis SKP1-like proteins, both in the yeast two-hybrid system and in vitro...
  63. Wang Y, Yang M. The Arabidopsis skp1-like1-1 (ask1-1) mutant and the mouse cells of a sporadic Parkinson's disease model created with downregulation of SKP1 share similar cellular defects. Parkinsonism Relat Disord. 2012;18:102-3 pubmed publisher