Gene Symbol: SHP2
Description: K-box region and MADS-box transcription factor family protein
Alias: AGAMOUS-like 5, AGL5, F7D19.17, F7D19_17, SHATTERPROOF 2, K-box region and MADS-box transcription factor family protein
Species: thale cress
Favaro R, Pinyopich A, Battaglia R, Kooiker M, Borghi L, Ditta G, et al
. MADS-box protein complexes control carpel and ovule development in Arabidopsis. Plant Cell. 2003;15:2603-11 pubmed
..carpel development and is part of a monophyletic clade of MADS-box genes that also includes SHATTERPROOF1 (SHP1), SHP2, and SEEDSTICK (STK)...
Brambilla V, Battaglia R, Colombo M, Masiero S, Bencivenga S, Kater M, et al
. Genetic and molecular interactions between BELL1 and MADS box factors support ovule development in Arabidopsis. Plant Cell. 2007;19:2544-56 pubmed
..such as the homeodomain factor BELL1 (BEL1) and MADS box family members SEEDSTICK (STK), SHATTERPROOF1 (SHP1), SHP2, and AGAMOUS...
Vrebalov J, Pan I, Arroyo A, McQuinn R, Chung M, Poole M, et al
. Fleshy fruit expansion and ripening are regulated by the Tomato SHATTERPROOF gene TAGL1. Plant Cell. 2009;21:3041-62 pubmed publisher
..In Arabidopsis, the duplicate SHP1 and SHP2 MADS box genes regulate the development of separation layers essential for pod shatter...
Kaufmann K, Anfang N, Saedler H, Theissen G. Mutant analysis, protein-protein interactions and subcellular localization of the Arabidopsis B sister (ABS) protein. Mol Genet Genomics. 2005;274:103-18 pubmed
..and multimeric complexes that also include the AGAMOUS-like proteins SEEDSTICK (STK) or SHATTERPROOF1/2 (SHP1, SHP2)...
Ehlers K, Bhide A, Tekleyohans D, Wittkop B, Snowdon R, Becker A. The MADS Box Genes ABS, SHP1, and SHP2 Are Essential for the Coordination of Cell Divisions in Ovule and Seed Coat Development and for Endosperm Formation in Arabidopsis thaliana. PLoS ONE. 2016;11:e0165075 pubmed publisher
..Two closely related MADS-box genes, SHATTERPROOF 1 and 2 (SHP1 and SHP2) are involved in specifying ovule integument identity in Arabidopsis thaliana...
Rathnakumar K, Savant S, Giri H, Ghosh A, Fisslthaler B, Fleming I, et al
. Angiopoietin-2 mediates thrombin-induced monocyte adhesion and endothelial permeability. J Thromb Haemost. 2016;14:1655-67 pubmed publisher
..Ang-2 mediates vessel leakage and monocyte adhesion through SHP-2/p38MAPK pathway. Calcium dependent SHP2/p38MAPK activation regulates Ang-2 expression through a feedback loop...
Losa A, Colombo M, Brambilla V, Colombo L. Genetic interaction between AINTEGUMENTA (ANT) and the ovule identity genes SEEDSTICK (STK), SHATTERPROOF1 (SHP1) and SHATTERPROOF2 (SHP2). Sex Plant Reprod. 2010;23:115-21 pubmed publisher
..cell fate is specified by ovule identity factors, such as SEEDSTICK (STK), SHATTERPROOF1 (SHP1) and SHATTERPROOF2 (SHP2)...
Colombo M, Brambilla V, Marcheselli R, Caporali E, Kater M, Colombo L. A new role for the SHATTERPROOF genes during Arabidopsis gynoecium development. Dev Biol. 2010;337:294-302 pubmed publisher
..SHATTERPROOF1 (SHP1) and SHP2, two closely related MADS-box genes, redundantly control the differentiation of the dehiscence zone and promote the ..
Krejci P, Masri B, Salazar L, Farrington Rock C, Prats H, Thompson L, et al
. Bisindolylmaleimide I suppresses fibroblast growth factor-mediated activation of Erk MAP kinase in chondrocytes by preventing Shp2 association with the Frs2 and Gab1 adaptor proteins. J Biol Chem. 2007;282:2929-36 pubmed
..Indeed, Bis I abolished the FGF2-mediated association of Shp2 tyrosine phosphatase with Frs2 and Gab1 adaptor proteins necessary for proper Ras activation...