Gene Symbol: SHP1
Description: K-box region and MADS-box transcription factor family protein
Alias: AGAMOUS-like 1, AGL1, SHATTERPROOF 1, K-box region and MADS-box transcription factor family protein
Species: thale cress

Top Publications

  1. Gauffin F, Diffner E, Gustafsson B, Nordgren A, Wingren A, Sander B, et al. Expression of PTEN and SHP1, investigated from tissue microarrays in pediatric acute lymphoblastic, leukemia. Pediatr Hematol Oncol. 2009;26:48-56 pubmed publisher
    PTEN and SHP1 are tumor suppressor genes involved in the regulation of cell cycle control and apoptosis...
  2. Brambilla V, Battaglia R, Colombo M, Masiero S, Bencivenga S, Kater M, et al. Genetic and molecular interactions between BELL1 and MADS box factors support ovule development in Arabidopsis. Plant Cell. 2007;19:2544-56 pubmed
    ..factors, such as the homeodomain factor BELL1 (BEL1) and MADS box family members SEEDSTICK (STK), SHATTERPROOF1 (SHP1), SHP2, and AGAMOUS...
  3. Vrebalov J, Pan I, Arroyo A, McQuinn R, Chung M, Poole M, et al. Fleshy fruit expansion and ripening are regulated by the Tomato SHATTERPROOF gene TAGL1. Plant Cell. 2009;21:3041-62 pubmed publisher
    ..In Arabidopsis, the duplicate SHP1 and SHP2 MADS box genes regulate the development of separation layers essential for pod shatter...
  4. Smaczniak C, Immink R, Muiño J, Blanvillain R, Busscher M, Busscher Lange J, et al. Characterization of MADS-domain transcription factor complexes in Arabidopsis flower development. Proc Natl Acad Sci U S A. 2012;109:1560-5 pubmed publisher
    ..Furthermore, members of other transcription factor families were identified as interaction partners of floral MADS-domain proteins suggesting various specific combinatorial modes of action. ..
  5. Matalon O, Fried S, Ben Shmuel A, Pauker M, Joseph N, Keizer D, et al. Dephosphorylation of the adaptor LAT and phospholipase C-γ by SHP-1 inhibits natural killer cell cytotoxicity. Sci Signal. 2016;9:ra54 pubmed publisher
    ..Together, these data identify previously uncharacterized SHP-1 substrates and inhibitory mechanisms that determine the response of NK cells. ..
  6. de Folter S, Shchennikova A, Franken J, Busscher M, Baskar R, Grossniklaus U, et al. A Bsister MADS-box gene involved in ovule and seed development in petunia and Arabidopsis. Plant J. 2006;47:934-46 pubmed
    ..The results presented here demonstrate the importance of the comparative analysis of key regulatory genes in various model systems to fully understand all aspects of plant development...
  7. Favaro R, Pinyopich A, Battaglia R, Kooiker M, Borghi L, Ditta G, et al. MADS-box protein complexes control carpel and ovule development in Arabidopsis. Plant Cell. 2003;15:2603-11 pubmed
    ..and carpel development and is part of a monophyletic clade of MADS-box genes that also includes SHATTERPROOF1 (SHP1), SHP2, and SEEDSTICK (STK)...
  8. Losa A, Colombo M, Brambilla V, Colombo L. Genetic interaction between AINTEGUMENTA (ANT) and the ovule identity genes SEEDSTICK (STK), SHATTERPROOF1 (SHP1) and SHATTERPROOF2 (SHP2). Sex Plant Reprod. 2010;23:115-21 pubmed publisher
    ..ovule integuments which cell fate is specified by ovule identity factors, such as SEEDSTICK (STK), SHATTERPROOF1 (SHP1) and SHATTERPROOF2 (SHP2)...
  9. Liljegren S, Ditta G, Eshed Y, Savidge B, Bowman J, Yanofsky M. SHATTERPROOF MADS-box genes control seed dispersal in Arabidopsis. Nature. 2000;404:766-70 pubmed
    ..Here we show that the closely related SHATTERPROOF (SHP1) and SHATTERPROOF2 (SHP2) MADS-box genes are required for fruit dehiscence in Arabidopsis...

More Information


  1. Kaufmann K, Anfang N, Saedler H, Theissen G. Mutant analysis, protein-protein interactions and subcellular localization of the Arabidopsis B sister (ABS) protein. Mol Genet Genomics. 2005;274:103-18 pubmed
    ..proteins and multimeric complexes that also include the AGAMOUS-like proteins SEEDSTICK (STK) or SHATTERPROOF1/2 (SHP1, SHP2)...
  2. Colombo M, Brambilla V, Marcheselli R, Caporali E, Kater M, Colombo L. A new role for the SHATTERPROOF genes during Arabidopsis gynoecium development. Dev Biol. 2010;337:294-302 pubmed publisher
    ..SHATTERPROOF1 (SHP1) and SHP2, two closely related MADS-box genes, redundantly control the differentiation of the dehiscence zone and ..
  3. Battaglia R, Brambilla V, Colombo L, Stuitje A, Kater M. Functional analysis of MADS-box genes controlling ovule development in Arabidopsis using the ethanol-inducible alc gene-expression system. Mech Dev. 2006;123:267-76 pubmed
    ..Recently, it has been shown that the three MADS-box genes SEEDSTICK (STK), SHATTERPROOF1 (SHP1) and SHP2 act redundantly to control ovule identity...
  4. Ehlers K, Bhide A, Tekleyohans D, Wittkop B, Snowdon R, Becker A. The MADS Box Genes ABS, SHP1, and SHP2 Are Essential for the Coordination of Cell Divisions in Ovule and Seed Coat Development and for Endosperm Formation in Arabidopsis thaliana. PLoS ONE. 2016;11:e0165075 pubmed publisher
    ..Two closely related MADS-box genes, SHATTERPROOF 1 and 2 (SHP1 and SHP2) are involved in specifying ovule integument identity in Arabidopsis thaliana...