Gene Symbol: SHM1
Description: serine transhydroxymethyltransferase 1
Alias: F20D10.50, F20D10_50, SERINE HYDROXYMETHYLTRANSFERASE 1, SERINE TRANSHYDROXYMETHYLASE, SERINE TRANSHYDROXYMETHYLTRANSFERASE, SHMT1, STM, serine transhydroxymethyltransferase 1, serine transhydroxymethyltransferase 1
Species: thale cress

Top Publications

  1. Engel N, Ewald R, Gupta K, Zrenner R, Hagemann M, Bauwe H. The presequence of Arabidopsis serine hydroxymethyltransferase SHM2 selectively prevents import into mesophyll mitochondria. Plant Physiol. 2011;157:1711-20 pubmed publisher
    ..In Arabidopsis (Arabidopsis thaliana), SHM1 has been identified as the photorespiratory isozyme, but little is known about the very similar SHM2...
  2. Zhou H, Zhao J, Yang Y, Chen C, Liu Y, Jin X, et al. Ubiquitin-specific protease16 modulates salt tolerance in Arabidopsis by regulating Na(+)/H(+) antiport activity and serine hydroxymethyltransferase stability. Plant Cell. 2012;24:5106-22 pubmed publisher
    ..Through yeast two-hybrid screening, we identified a putative target of UBP16, SERINE HYDROXYMETHYLTRANSFERASE1 (SHM1), which has previously been reported to be involved in photorespiration and salt tolerance in Arabidopsis...
  3. Wei Z, Sun K, Sandoval F, Cross J, Gordon C, Kang C, et al. Folate polyglutamylation eliminates dependence of activity on enzyme concentration in mitochondrial serine hydroxymethyltransferases from Arabidopsis thaliana. Arch Biochem Biophys. 2013;536:87-96 pubmed publisher
    ..Modeling of the enzyme structures presented features that may explain the activity differences between the mitochondrial and cytosolic isozymes...
  4. Takahashi S, Bauwe H, Badger M. Impairment of the photorespiratory pathway accelerates photoinhibition of photosystem II by suppression of repair but not acceleration of damage processes in Arabidopsis. Plant Physiol. 2007;144:487-94 pubmed
    ..Our results suggest that the photorespiratory pathway helps avoid inhibition of the synthesis of the D1 protein, which is important for the repair of photodamaged PSII upon interruption of the Calvin cycle. ..
  5. Kuhn A, Engqvist M, Jansen E, Weber A, Jakobs C, Maurino V. D-2-hydroxyglutarate metabolism is linked to photorespiration in the shm1-1 mutant. Plant Biol (Stuttg). 2013;15:776-84 pubmed publisher
    The Arabidopsis mutant shm1-1 is defective in mitochondrial serine hydroxymethyltransferase 1 activity and displays a lethal photorespiratory phenotype at ambient CO2 concentration but grows normally at high CO2 ...
  6. Zhao J, Zhou H, Li Y. UBIQUITIN-SPECIFIC PROTEASE16 interacts with a HEAVY METAL ASSOCIATED ISOPRENYLATED PLANT PROTEIN27 and modulates cadmium tolerance. Plant Signal Behav. 2013;8:doi: 10.4161/psb.25680 pubmed
    ..Meanwhile, the ubp16 mutant showed more sensitive to cadmium than wild-type. Taken together, HI PP27 may be another target of UBP16 in cadmium response. ..
  7. McClung C, Hsu M, Painter J, Gagne J, Karlsberg S, Salomé P. Integrated temporal regulation of the photorespiratory pathway. Circadian regulation of two Arabidopsis genes encoding serine hydroxymethyltransferase. Plant Physiol. 2000;123:381-92 pubmed
    ..We examined mRNA accumulation for two of these family members, including one probable photorespiratory gene (SHM1) and a second gene expressed maximally in roots (SHM4), and show that both exhibit circadian oscillations in mRNA ..
  8. Voll L, Jamai A, Renné P, Voll H, McClung C, Weber A. The photorespiratory Arabidopsis shm1 mutant is deficient in SHM1. Plant Physiol. 2006;140:59-66 pubmed
    ..The Arabidopsis (Arabidopsis thaliana) mutant shm (now designated shm1-1) is defective in mitochondrial SHMT activity and displays a lethal photorespiratory phenotype when grown at ..
  9. Jamai A, Salome P, Schilling S, Weber A, McClung C. Arabidopsis photorespiratory serine hydroxymethyltransferase activity requires the mitochondrial accumulation of ferredoxin-dependent glutamate synthase. Plant Cell. 2009;21:595-606 pubmed publisher
    ..One class of mutants deficient in SHMT1 activity affects SHM1, which encodes the mitochondrial SHMT required for photorespiration...

More Information


  1. Xu Y, Wang B, Zhu Y. Identification of proteins expressed at extremely low level in Arabidopsis leaves. Biochem Biophys Res Commun. 2007;358:808-12 pubmed
    ..Our results suggest that polyU or similar media may be combined with 2-DE techniques to identify cellular proteins with extremely low transcription levels to fulfill specific research needs. ..
  2. Beckmann K, Dzuibany C, Biehler K, Fock H, Hell R, Migge A, et al. Photosynthesis and fluorescence quenching, and the mRNA levels of plastidic glutamine synthetase or of mitochondrial serine hydroxymethyltransferase (SHMT) in the leaves of the wild-type and of the SHMT-deficient stm mutant of Arabidopsis thaliana in. Planta. 1997;202:379-86 pubmed
    ..was demonstrated by the ability of the conditionally lethal serine hydroxymethyltransferase (SHMT)-deficient stm mutant of A. thaliana to grown normally under these conditions...
  3. Moreno J, Martin R, Castresana C. Arabidopsis SHMT1, a serine hydroxymethyltransferase that functions in the photorespiratory pathway influences resistance to biotic and abiotic stress. Plant J. 2005;41:451-63 pubmed
    We found that a recessive mutation, shmt1-1, causes aberrant regulation of cell death resulting in chlorotic and necrotic lesion formation under a variety of environmental conditions...