Gene Symbol: SGS3
Description: XS domain-containing protein / XS zinc finger domain-containing protein-like protein
Alias: ATSGS3, MQM1.17, MQM1_17, SUPPRESSOR OF GENE SILENCING 3, XS domain-containing protein / XS zinc finger domain-containing protein-like protein
Species: thale cress
Okano Y, Senshu H, Hashimoto M, Neriya Y, Netsu O, Minato N, et al
. In Planta Recognition of a Double-Stranded RNA Synthesis Protein Complex by a Potexviral RNA Silencing Suppressor. Plant Cell. 2014;26:2168-2183 pubmed
..abnormalities in Arabidopsis thaliana similar to those observed in mutants of SUPPRESSOR OF GENE SILENCING3 (SGS3) and RNA-DEPENDENT RNA POLYMERASE6 (RDR6) required for the trans-acting small interfering RNA synthesis pathway...
Yoshikawa M, Iki T, Tsutsui Y, Miyashita K, Poethig R, Habu Y, et al
. 3' fragment of miR173-programmed RISC-cleaved RNA is protected from degradation in a complex with RISC and SGS3. Proc Natl Acad Sci U S A. 2013;110:4117-22 pubmed publisher
..transformed into tasiRNAs by a pathway that requires several factors including SUPPRESSOR OF GENE SILENCING3 (SGS3) and RNA-DEPENDENT RNA POLYMERASE6...
Cheng X, Wang A. The Potyvirus Silencing Suppressor Protein VPg Mediates Degradation of SGS3 via Ubiquitination and Autophagy Pathways. J Virol. 2017;91: pubmed
..In this study, we show that infection by Turnip mosaic virus (TuMV) causes reduced levels of suppressor of gene silencing 3 (SGS3), a key component of the RNA silencing pathway that functions in double-stranded RNA synthesis ..
Peragine A, Yoshikawa M, Wu G, Albrecht H, Poethig R. SGS3 and SGS2/SDE1/RDR6 are required for juvenile development and the production of trans-acting siRNAs in Arabidopsis. Genes Dev. 2004;18:2368-79 pubmed
..alleles of two genes required for posttranscriptional gene silencing (PTGS)--SUPPRESSOR OF GENE SILENCING3 (SGS3) and SUPPRESSOR OF GENE SILENCING2(SGS2)/SILENCING DEFECTIVE1 (SDE1)/RNA-DEPENDENT POLYMERASE6 (RDR6)...
Elmayan T, Adenot X, Gissot L, Lauressergues D, Gy I, Vaucheret H. A neomorphic sgs3 allele stabilizing miRNA cleavage products reveals that SGS3 acts as a homodimer. FEBS J. 2009;276:835-44 pubmed publisher
The putative RNA-binding protein SUPPRESSOR OF GENE SILENCING 3 (SGS3) protects RNA from degradation before transformation into dsRNA by the RNA-dependent RNA polymerase RDR6 during plant post-transcriptional gene silencing and trans-..
Zhong S, Liu J, Jin H, Lin L, Li Q, Chen Y, et al
. Warm temperatures induce transgenerational epigenetic release of RNA silencing by inhibiting siRNA biogenesis in Arabidopsis. Proc Natl Acad Sci U S A. 2013;110:9171-6 pubmed publisher
..We discovered that the temperature increase reduced the protein abundance of SUPPRESSOR OF GENE SILENCING 3, as a consequence, attenuating the formation of stable dsRNAs required for siRNA biogenesis...
Adenot X, Elmayan T, Lauressergues D, Boutet S, Bouche N, Gasciolli V, et al
. DRB4-dependent TAS3 trans-acting siRNAs control leaf morphology through AGO7. Curr Biol. 2006;16:927-32 pubmed
..TAS gene transcripts are cleaved by miRNAs; the cleavage products are protected against degradation by SGS3, copied into dsRNA by RDR6, and diced into ta-siRNAs by DCL4 ...
Lam P, Zhao L, McFarlane H, Aiga M, Lam V, Hooker T, et al
. RDR1 and SGS3, components of RNA-mediated gene silencing, are required for the regulation of cuticular wax biosynthesis in developing inflorescence stems of Arabidopsis. Plant Physiol. 2012;159:1385-95 pubmed publisher
Mourrain P, Beclin C, Elmayan T, Feuerbach F, Godon C, Morel J, et al
. Arabidopsis SGS2 and SGS3 genes are required for posttranscriptional gene silencing and natural virus resistance. Cell. 2000;101:533-42 pubmed
..Here, we report the isolation of sgs2 and sgs3 Arabidopsis mutants impaired in PTGS...