SERRATE

Summary

Gene Symbol: SERRATE
Description: C2H2 zinc-finger protein SERRATE (SE)
Alias: SERRATE, T20P8.15, T20P8_15, C2H2 zinc-finger protein SERRATE (SE)
Species: thale cress
Products:     SERRATE

Top Publications

  1. Yang L, Liu Z, Lu F, Dong A, Huang H. SERRATE is a novel nuclear regulator in primary microRNA processing in Arabidopsis. Plant J. 2006;47:841-50 pubmed
    The Arabidopsis gene SERRATE (SE) controls leaf development, meristem activity, inflorescence architecture and developmental phase transition...
  2. Lobbes D, Rallapalli G, Schmidt D, Martin C, Clarke J. SERRATE: a new player on the plant microRNA scene. EMBO Rep. 2006;7:1052-8 pubmed
    ..The serrate-1 (se-1) mutant of Arabidopsis also shows a highly pleiotropic phenotype, which overlaps with the phenotypes of ..
  3. Machida S, Chen H, Adam Yuan Y. Molecular insights into miRNA processing by Arabidopsis thaliana SERRATE. Nucleic Acids Res. 2011;39:7828-36 pubmed publisher
    ..b>SERRATE (SE) protein is an essential component for miRNA processing by assisting DCL1 for accurate cleavage...
  4. Christie M, Carroll B. SERRATE is required for intron suppression of RNA silencing in Arabidopsis. Plant Signal Behav. 2011;6:2035-7 pubmed
    ..Here, we show that SERRATE (SE) is also required for splicing-mediated suppression of RNA silencing in Arabidopsis...
  5. Clarke J, Tack D, Findlay K, Van Montagu M, Van Lijsebettens M. The SERRATE locus controls the formation of the early juvenile leaves and phase length in Arabidopsis. Plant J. 1999;20:493-501 pubmed
    ..Characterization of the serrate mutant (CS3257; Arabidopsis Biological Research Center) revealed defects in both vegetative and inflores-cence ..
  6. Grigg S, Canales C, Hay A, Tsiantis M. SERRATE coordinates shoot meristem function and leaf axial patterning in Arabidopsis. Nature. 2005;437:1022-6 pubmed
    ..Here we show that the zinc-finger protein SERRATE acts in a microRNA (miRNA) gene-silencing pathway to regulate expression of the HD-Zip III gene PHABULOSA (PHB) ..
  7. Fang Y, Spector D. Identification of nuclear dicing bodies containing proteins for microRNA biogenesis in living Arabidopsis plants. Curr Biol. 2007;17:818-23 pubmed
    ..in the nucleus via the enzyme Dicer-like1 (DCL1) and other proteins including the zinc-finger-domain protein Serrate (SE) and a double-stranded RNA (dsRNA) binding-domain protein, Hyponastic Leaves1 (HYL1)...
  8. Fujioka Y, Utsumi M, Ohba Y, Watanabe Y. Location of a possible miRNA processing site in SmD3/SmB nuclear bodies in Arabidopsis. Plant Cell Physiol. 2007;48:1243-53 pubmed
    ..In plants, it has been reported that Dicer-like 1 (DCL1), HYPONASTIC LEAVES1 (HYL1) and SERRATE (SE) are involved in the production of miRNAs...
  9. Prigge M, Wagner D. The arabidopsis serrate gene encodes a zinc-finger protein required for normal shoot development. Plant Cell. 2001;13:1263-79 pubmed
    ..The serrate (se) mutant of Arabidopsis displays defects in the initiation and elaboration of cotyledons and post-embryonic ..

More Information

Publications26

  1. Yang S, Chen H, Yang J, Machida S, Chua N, Yuan Y. Structure of Arabidopsis HYPONASTIC LEAVES1 and its molecular implications for miRNA processing. Structure. 2010;18:594-605 pubmed publisher
    ..LEAVES1 (HYL1) is a double-stranded RNA-binding protein that forms a complex with DICER-LIKE1 (DCL1) and SERRATE to facilitate processing of primary miRNAs into microRNAs (miRNAs)...
  2. Manavella P, Hagmann J, Ott F, Laubinger S, Franz M, Macek B, et al. Fast-forward genetics identifies plant CPL phosphatases as regulators of miRNA processing factor HYL1. Cell. 2012;151:859-870 pubmed publisher
    ..is greatly enhanced through the RNA binding protein HYPONASTIC LEAVES 1 (HYL1) and the zinc finger protein SERRATE (SE)...
  3. Wang L, Song X, Gu L, Li X, Cao S, Chu C, et al. NOT2 proteins promote polymerase II-dependent transcription and interact with multiple MicroRNA biogenesis factors in Arabidopsis. Plant Cell. 2013;25:715-27 pubmed publisher
    ..with polymerase II and other miRNA processing factors, including two cap binding proteins, CBP80/ABH1, CBP20, and SERRATE (SE). Finally, we found that the mRNA levels of some protein coding genes were also affected...
  4. Speth C, Willing E, Rausch S, Schneeberger K, Laubinger S. RACK1 scaffold proteins influence miRNA abundance in Arabidopsis. Plant J. 2013;76:433-45 pubmed publisher
    ..Additional proteins act in concert with DCL1 (e.g. HYL1 and SERRATE) or AGO1 to facilitate efficient and precise pri-miRNA processing and miRNA loading, respectively...
  5. Laubinger S, Sachsenberg T, Zeller G, Busch W, Lohmann J, R├Ątsch G, et al. Dual roles of the nuclear cap-binding complex and SERRATE in pre-mRNA splicing and microRNA processing in Arabidopsis thaliana. Proc Natl Acad Sci U S A. 2008;105:8795-800 pubmed publisher
    ..DCL1), the double-stranded RNA-binding protein HYPONASTIC LEAVES1 (HYL1), and the zinc finger protein SERRATE (SE)...
  6. Zhang S, Liu Y, Yu B. PRL1, an RNA-binding protein, positively regulates the accumulation of miRNAs and siRNAs in Arabidopsis. PLoS Genet. 2014;10:e1004841 pubmed publisher
    ..Based on these results, we propose that CDC5 and PRL1 cooperatively regulate pri-miRNA levels, which results in their synergistic effects on miRNA accumulation, while they function together as a complex to enhance DCL1 activity. ..
  7. Yang X, Ren W, Zhao Q, Zhang P, Wu F, He Y. Homodimerization of HYL1 ensures the correct selection of cleavage sites in primary miRNA. Nucleic Acids Res. 2014;42:12224-36 pubmed publisher
    ..LEAVES1 (HYL1) is a double-stranded RNA-binding protein that forms a complex with DICER-LIKE1 (DCL1) and SERRATE (SE) to process primary miRNA (pri-miRNA) into mature miRNA...
  8. Chen T, Cui P, Xiong L. The RNA-binding protein HOS5 and serine/arginine-rich proteins RS40 and RS41 participate in miRNA biogenesis in Arabidopsis. Nucleic Acids Res. 2015;43:8283-98 pubmed publisher
    ..Accuracy of the processing of pri-miRNA into mature miRNA in plants can be enhanced by SERRATE (SE) and HYPONASTIC LEAVES 1 (HYL1)...
  9. Liu Q, Yan Q, Liu Y, Hong F, Sun Z, Shi L, et al. Complementation of HYPONASTIC LEAVES1 by double-strand RNA-binding domains of DICER-LIKE1 in nuclear dicing bodies. Plant Physiol. 2013;163:108-17 pubmed publisher
  10. Niu D, Lii Y, Chellappan P, Lei L, Peralta K, Jiang C, et al. miRNA863-3p sequentially targets negative immune regulator ARLPKs and positive regulator SERRATE upon bacterial infection. Nat Commun. 2016;7:11324 pubmed publisher
    ..Later during infection, miR863-3p silences SERRATE, which is essential for miRNA accumulation and positively regulates defence, through translational inhibition...
  11. Yan J, Wang P, Wang B, Hsu C, Tang K, Zhang H, et al. The SnRK2 kinases modulate miRNA accumulation in Arabidopsis. PLoS Genet. 2017;13:e1006753 pubmed publisher
    ..biogenesis in plants requires a processing complex that consists of the core components DICER-LIKE 1 (DCL1), SERRATE (SE) and HYPONASTIC LEAVES (HYL1)...
  12. Liu J, Jung C, Xu J, Wang H, Deng S, Bernad L, et al. Genome-wide analysis uncovers regulation of long intergenic noncoding RNAs in Arabidopsis. Plant Cell. 2012;24:4333-45 pubmed publisher
    ..Further analysis of transcriptome data in 11 mutants uncovered SERRATE, CAP BINDING PROTEIN20 (CBP20), and CBP80 as regulators of lincRNA expression and biogenesis...
  13. Iwata Y, Takahashi M, Fedoroff N, Hamdan S. Dissecting the interactions of SERRATE with RNA and DICER-LIKE 1 in Arabidopsis microRNA precursor processing. Nucleic Acids Res. 2013;41:9129-40 pubmed publisher
    ..double-stranded RNA-binding protein HYPONASTIC LEAVES 1 and the zinc-finger (ZnF) domain-containing protein SERRATE (SE)...
  14. Raczynska K, Stepien A, Kierzkowski D, Kalak M, Bajczyk M, McNicol J, et al. The SERRATE protein is involved in alternative splicing in Arabidopsis thaliana. Nucleic Acids Res. 2014;42:1224-44 pubmed publisher
    ..Here we show that both subunits of AtCBC (AtCBP20 and AtCBP80) interact with SERRATE (AtSE), a protein involved in the microRNA biogenesis pathway...
  15. Voisin D, Nawrath C, Kurdyukov S, Franke R, Reina Pinto J, Efremova N, et al. Dissection of the complex phenotype in cuticular mutants of Arabidopsis reveals a role of SERRATE as a mediator. PLoS Genet. 2009;5:e1000703 pubmed publisher
    ..Using MASTA for an in silico suppressor/enhancer screen, we identified SERRATE (SE), which encodes a protein of RNA-processing multi-protein complexes, as a likely enhancer...
  16. Cho S, Ryu M, Poulsen C, Kim J, Oh T, Choi S, et al. HIGLE is a bifunctional homing endonuclease that directly interacts with HYL1 and SERRATE in Arabidopsis thaliana. FEBS Lett. 2017;591:1383-1393 pubmed publisher
    ..microprocessor minimally consists of three components: Dicer-like protein 1 (DCL1), HYPONASTIC LEAF 1 (HYL1), and SERRATE (SE). To precisely modulate miRNA maturation, the microprocessor cooperates with at least 12 proteins in plants...
  17. Chenu K, Franck N, Lecoeur J. Simulations of virtual plants reveal a role for SERRATE in the response of leaf development to light in Arabidopsis thaliana. New Phytol. 2007;175:472-81 pubmed
    The SERRATE gene (SE) was shown to determine leaf organogenesis and morphogenesis patterning in Arabidopsis thaliana. The se-1 mutant was used here to investigate the role of SE in leaf development in response to incident light...