Gene Symbol: ROC4
Description: rotamase CYP 4
Alias: CYP20-3, PEPTIDYLPROLYL ISOMERASE ROC4, T17J13.1, cyclophilin 20-3, rotamase CYP 4, rotamase CYP 4
Species: thale cress
Lippuner V, Chou I, Scott S, Ettinger W, Theg S, Gasser C. Cloning and characterization of chloroplast and cytosolic forms of cyclophilin from Arabidopsis thaliana. J Biol Chem. 1994;269:7863-8 pubmed
..We have isolated cDNA clones of two genes (designated ROC1 and ROC4) encoding CyP homologs from Arabidopsis thaliana (L.)...
Liebthal M, StrÃ¼ve M, Li X, Hertle Y, Maynard D, Hellweg T, et al
. Redox-Dependent Conformational Dynamics of Decameric 2-Cysteine Peroxiredoxin and its Interaction with Cyclophilin 20-3. Plant Cell Physiol. 2016;57:1415-1425 pubmed
Chou I, Gasser C. Characterization of the cyclophilin gene family of Arabidopsis thaliana and phylogenetic analysis of known cyclophilin proteins. Plant Mol Biol. 1997;35:873-92 pubmed
We have isolated four members of the Arabidopsis cyclophilin (CyP) gene family, designated ROC1 to ROC4 (rotamase CyP)...
Laxa M, König J, Dietz K, Kandlbinder A. Role of the cysteine residues in Arabidopsis thaliana cyclophilin CYP20-3 in peptidyl-prolyl cis-trans isomerase and redox-related functions. Biochem J. 2007;401:287-97 pubmed
..In addition, it was shown that the isomerization and disulfide-reduction activities are two independent functions of CYP20-3 that both are regulated by the redox state of its active centre. ..
Ghelis T, Bolbach G, Clodic G, Habricot Y, Miginiac E, Sotta B, et al
. Protein tyrosine kinases and protein tyrosine phosphatases are involved in abscisic acid-dependent processes in Arabidopsis seeds and suspension cells. Plant Physiol. 2008;148:1668-80 pubmed publisher
Dominguez Solis J, He Z, Lima A, Ting J, Buchanan B, Luan S. A cyclophilin links redox and light signals to cysteine biosynthesis and stress responses in chloroplasts. Proc Natl Acad Sci U S A. 2008;105:16386-91 pubmed publisher
..The cyclophilin CYP20-3 (also known as "ROC4") is the only member of this group located in the stroma (soluble phase) of chloroplasts...
Cai W, Ma J, Guo J, Zhang L. Function of ROC4 in the efficient repair of photodamaged photosystem II in Arabidopsis. Photochem Photobiol. 2008;84:1343-8 pubmed publisher
b>ROC4 is the only cyclophilin in the chloroplast stroma. Here, we used the T-DNA knockout mutant of roc4 to study the physiological role of ROC4 in vivo in Arabidopsis thaliana...
Park S, Li W, Viehhauser A, He B, Kim S, Nilsson A, et al
. Cyclophilin 20-3 relays a 12-oxo-phytodienoic acid signal during stress responsive regulation of cellular redox homeostasis. Proc Natl Acad Sci U S A. 2013;110:9559-64 pubmed publisher
..Thus, we conclude that CYP20-3 is a key effector protein that links OPDA signaling to amino acid biosynthesis and cellular redox homeostasis in stress responses. ..
Deng W, Chen L, Wood D, Metcalfe T, Liang X, Gordon M, et al
. Agrobacterium VirD2 protein interacts with plant host cyclophilins. Proc Natl Acad Sci U S A. 1998;95:7040-5 pubmed
..These data strongly suggest that host cyclophilins play a role in T-DNA transfer. ..