Gene Symbol: ROC1
Description: rotamase CYP 1
Alias: CYCLOPHILIN, T9A14.20, T9A14_20, rotamase CYP 1, rotamase CYP 1
Species: thale cress
Chou I, Gasser C. Characterization of the cyclophilin gene family of Arabidopsis thaliana and phylogenetic analysis of known cyclophilin proteins. Plant Mol Biol. 1997;35:873-92 pubmed
We have isolated four members of the Arabidopsis cyclophilin (CyP) gene family, designated ROC1 to ROC4 (rotamase CyP)...
Deng W, Chen L, Wood D, Metcalfe T, Liang X, Gordon M, et al
. Agrobacterium VirD2 protein interacts with plant host cyclophilins. Proc Natl Acad Sci U S A. 1998;95:7040-5 pubmed
..The VirD2-cyclophilin interaction is disrupted in vitro by cyclosporin A, which also inhibits Agrobacterium-mediated transformation ..
Coaker G, Falick A, Staskawicz B. Activation of a phytopathogenic bacterial effector protein by a eukaryotic cyclophilin. Science. 2005;308:548-50 pubmed
..AvrRpt2 is delivered into the plant cell, where it is activated by a eukaryotic factor that we identify as cyclophilin. This activation of AvrRpt2 is necessary for protease activity. Active AvrRpt2 can then directly cleave RIN4.
Trupkin S, Mora Garcia S, Casal J. The cyclophilin ROC1 links phytochrome and cryptochrome to brassinosteroid sensitivity. Plant J. 2012;71:712-23 pubmed publisher
..The roc1-1D mutant, showing elevated expression of the ROTAMASE CYCLOPHILIN 1 (ROC1/AtCYP18-3) gene, and partial loss-of function roc1 alleles, has defects in phytochrome A (phyA)-, ..
Kovalev N, Nagy P. Cyclophilin A binds to the viral RNA and replication proteins, resulting in inhibition of tombusviral replicase assembly. J Virol. 2013;87:13330-42 pubmed publisher
..In this report, we further characterize single-domain cyclophilins, including the mammalian cyclophilin A and plant Roc1 and Roc2, which are orthologs of the yeast Cpr1p cyclophilin, a known inhibitor of TBSV ..
Li M, Ma X, Chiang Y, Yadeta K, Ding P, Dong L, et al
. Proline isomerization of the immune receptor-interacting protein RIN4 by a cyclophilin inhibits effector-triggered immunity in Arabidopsis. Cell Host Microbe. 2014;16:473-83 pubmed publisher
..We find that RIN4 also interacts with the prolyl-peptidyl isomerase (PPIase) ROC1, which is reduced upon RIN4 Thr166 phosphorylation. ROC1 suppresses RPM1 immunity in a PPIase-dependent manner...
Ma X, Song L, Yang Y, Liu D. A gain-of-function mutation in the ROC1 gene alters plant architecture in Arabidopsis. New Phytol. 2013;197:751-62 pubmed publisher
..Using genetic and molecular approaches, we analyzed the roles of a mutated cyclophilin in the control of plant architecture...