RIN4

Summary

Gene Symbol: RIN4
Description: RPM1 interacting protein 4
Alias: AtRIN4, RPM1 interacting protein 4, RPM1 interacting protein 4
Species: thale cress

Top Publications

  1. Axtell M, Staskawicz B. Initiation of RPS2-specified disease resistance in Arabidopsis is coupled to the AvrRpt2-directed elimination of RIN4. Cell. 2003;112:369-77 pubmed
    ..We demonstrate that RPS2 physically interacts with Arabidopsis RIN4 and that AvrRpt2 causes the elimination of RIN4 during activation of the RPS2 pathway...
  2. Day B, Dahlbeck D, Staskawicz B. NDR1 interaction with RIN4 mediates the differential activation of multiple disease resistance pathways in Arabidopsis. Plant Cell. 2006;18:2782-91 pubmed publisher
    ..involves the physical association of at least two R proteins with the negative regulator RPM1 INTERACTING PROTEIN4 (RIN4). While the RIN4-RPS2 (for RESISTANCE TO P. SYRINGAE2) and RIN4-RPM1 (for RESISTANCE TO P...
  3. Mackey D, Holt B, Wiig A, Dangl J. RIN4 interacts with Pseudomonas syringae type III effector molecules and is required for RPM1-mediated resistance in Arabidopsis. Cell. 2002;108:743-54 pubmed
    ..An RPM1-interacting protein (RIN4) coimmunoprecipitates from plant cell extracts with AvrB, AvrRpm1, or RPM1...
  4. Kim H, Desveaux D, Singer A, Patel P, Sondek J, Dangl J. The Pseudomonas syringae effector AvrRpt2 cleaves its C-terminally acylated target, RIN4, from Arabidopsis membranes to block RPM1 activation. Proc Natl Acad Sci U S A. 2005;102:6496-501 pubmed
    ..The Arabidopsis RIN4 protein is targeted by three different type III effectors...
  5. Kim M, da Cunha L, McFall A, Belkhadir Y, DebRoy S, Dangl J, et al. Two Pseudomonas syringae type III effectors inhibit RIN4-regulated basal defense in Arabidopsis. Cell. 2005;121:749-59 pubmed
    ..b>RIN4 is an Arabidopsis protein targeted by AvrRpt2 and AvrRpm1 for degradation and phosphorylation, respectively...
  6. Mackey D, Belkhadir Y, Alonso J, Ecker J, Dangl J. Arabidopsis RIN4 is a target of the type III virulence effector AvrRpt2 and modulates RPS2-mediated resistance. Cell. 2003;112:379-89 pubmed
    ..previously that two unrelated type III effectors from Pseudomonas syringae target and modify the Arabidopsis RIN4 protein...
  7. Lim M, Kunkel B. The Pseudomonas syringae type III effector AvrRpt2 promotes virulence independently of RIN4, a predicted virulence target in Arabidopsis thaliana. Plant J. 2004;40:790-8 pubmed
    ..The activation of RPS2 is coupled to the AvrRpt2-induced disappearance of the A. thaliana RIN4 protein. However, the significance of this RIN4 elimination to AvrRpt2 virulence function is unresolved...
  8. Qi Y, Katagiri F. Purification of low-abundance Arabidopsis plasma-membrane protein complexes and identification of candidate components. Plant J. 2009;57:932-44 pubmed publisher
    ..We identified RIN4, a known RPS2 interactor, as well as other potential components of the RPS2 complex(es)...
  9. Liu J, Elmore J, Lin Z, Coaker G. A receptor-like cytoplasmic kinase phosphorylates the host target RIN4, leading to the activation of a plant innate immune receptor. Cell Host Microbe. 2011;9:137-46 pubmed publisher
    ..Both effectors associate with and affect the phosphorylation of RIN4, an immune regulator...

More Information

Publications27

  1. Day B, Dahlbeck D, Huang J, Chisholm S, Li D, Staskawicz B. Molecular basis for the RIN4 negative regulation of RPS2 disease resistance. Plant Cell. 2005;17:1292-305 pubmed
    ..nucleotide binding site/leucine-rich repeat protein from Arabidopsis thaliana, associates with RPM1 Interacting Protein 4 (RIN4) and that this association functions to modulate the RPS2-mediated defense pathway in response to ..
  2. Afzal A, da Cunha L, Mackey D. Separable fragments and membrane tethering of Arabidopsis RIN4 regulate its suppression of PAMP-triggered immunity. Plant Cell. 2011;23:3798-811 pubmed publisher
    RPM1-interacting protein 4 (RIN4) is a multifunctional Arabidopsis thaliana protein that regulates plant immune responses to pathogen-associated molecular patterns (PAMPs) and bacterial type III effector proteins (T3Es)...
  3. Century K, Holub E, Staskawicz B. NDR1, a locus of Arabidopsis thaliana that is required for disease resistance to both a bacterial and a fungal pathogen. Proc Natl Acad Sci U S A. 1995;92:6597-601 pubmed
    ..Characterization of the ndr1-1 mutation suggests that a common step exists in pathways of resistance to two unrelated pathogens. ..
  4. Luo Y, Caldwell K, Wroblewski T, Wright M, Michelmore R. Proteolysis of a negative regulator of innate immunity is dependent on resistance genes in tomato and Nicotiana benthamiana and induced by multiple bacterial effectors. Plant Cell. 2009;21:2458-72 pubmed publisher
    RPM1-interacting protein 4 (RIN4), a negative regulator of the basal defense response in plants, is targeted by multiple bacterial virulence effectors...
  5. Sun X, Greenwood D, Templeton M, Libich D, McGhie T, Xue B, et al. The intrinsically disordered structural platform of the plant defence hub protein RPM1-interacting protein 4 provides insights into its mode of action in the host-pathogen interface and evolution of the nitrate-induced domain protein family. FEBS J. 2014;281:3955-79 pubmed publisher
    ..Little is known about the overall protein structure of AtRIN4, especially in its unbound form, and the relevance of structure to its diverse biological functions...
  6. Qi Y, Tsuda K, Glazebrook J, Katagiri F. Physical association of pattern-triggered immunity (PTI) and effector-triggered immunity (ETI) immune receptors in Arabidopsis. Mol Plant Pathol. 2011;12:702-8 pubmed publisher
    ..Our findings suggest that signalling interactions occur between PTI and ETI at very early stages and/or that FLS2 forms a PTI signalling complex, some components of which are guarded by R proteins. ..
  7. Wilton M, Subramaniam R, Elmore J, Felsensteiner C, Coaker G, Desveaux D. The type III effector HopF2Pto targets Arabidopsis RIN4 protein to promote Pseudomonas syringae virulence. Proc Natl Acad Sci U S A. 2010;107:2349-54 pubmed publisher
    ..The Arabidopsis protein RIN4 plays an important role in both branches of plant immunity...
  8. Cui H, Wang Y, Xue L, Chu J, Yan C, Fu J, et al. Pseudomonas syringae effector protein AvrB perturbs Arabidopsis hormone signaling by activating MAP kinase 4. Cell Host Microbe. 2010;7:164-75 pubmed publisher
    ..mitogen-activated protein kinase MAP kinase 4 (MPK4), HSP90 chaperone components, and the AvrB-interacting protein, RIN4. AvrB interacts with MPK4 and the HSP90 chaperone, and AvrB induces MPK4 activation in a manner promoted by HSP90; ..
  9. Liu J, Elmore J, Fuglsang A, Palmgren M, Staskawicz B, Coaker G. RIN4 functions with plasma membrane H+-ATPases to regulate stomatal apertures during pathogen attack. PLoS Biol. 2009;7:e1000139 pubmed publisher
    ..The Arabidopsis protein RIN4 is a negative regulator of plant immunity...
  10. Li M, Ma X, Chiang Y, Yadeta K, Ding P, Dong L, et al. Proline isomerization of the immune receptor-interacting protein RIN4 by a cyclophilin inhibits effector-triggered immunity in Arabidopsis. Cell Host Microbe. 2014;16:473-83 pubmed publisher
    ..ETI receptor RPM1 is activated via bacterial effector AvrB-induced phosphorylation of the RPM1-interacting protein RIN4 at Threonine 166...
  11. Lee D, Bourdais G, Yu G, Robatzek S, Coaker G. Phosphorylation of the Plant Immune Regulator RPM1-INTERACTING PROTEIN4 Enhances Plant Plasma Membrane H⁺-ATPase Activity and Inhibits Flagellin-Triggered Immune Responses in Arabidopsis. Plant Cell. 2015;27:2042-56 pubmed publisher
    ..targets multiple host proteins during infection, including the plant immune regulator RPM1-INTERACTING PROTEIN4 (RIN4) and RPM1-INDUCED PROTEIN KINASE (RIPK)...
  12. Chung E, da Cunha L, Wu A, Gao Z, Cherkis K, Afzal A, et al. Specific threonine phosphorylation of a host target by two unrelated type III effectors activates a host innate immune receptor in plants. Cell Host Microbe. 2011;9:125-36 pubmed publisher
    ..Although neither effector is itself a kinase, AvrRpm1 and AvrB are known to target Arabidopsis RIN4, a negative regulator of basal plant defense, for phosphorylation. We show that RIN4 phosphorylation activates RPM1...
  13. Takemoto D, Jones D. Membrane release and destabilization of Arabidopsis RIN4 following cleavage by Pseudomonas syringae AvrRpt2. Mol Plant Microbe Interact. 2005;18:1258-68 pubmed
    The Arabidopsis RIN4 protein mediates interaction between the Pseudomonas syringae type III effector proteins AvrB, AvrRpm1, and AvrRpt2 and the Arabidopsis disease-resistance proteins RPM1 and RPS2...
  14. Russell A, Ashfield T, Innes R. Pseudomonas syringae Effector AvrPphB Suppresses AvrB-Induced Activation of RPM1 but Not AvrRpm1-Induced Activation. Mol Plant Microbe Interact. 2015;28:727-35 pubmed publisher
    ..In Arabidopsis, AvrB induces RPM1-interacting protein kinase (RIPK) to phosphorylate a disease regulator known as RIN4, which subsequently activates RPM1-mediated defenses...
  15. Sabol P, Kulich I, Zarsky V. RIN4 recruits the exocyst subunit EXO70B1 to the plasma membrane. J Exp Bot. 2017;68:3253-3265 pubmed publisher
    ..subunit, a protein which was previously associated with both the defense response and autophagy, and RPM1 INTERACTING PROTEIN 4 (RIN4), the best studied member of the NOI protein family and a known regulator of plant defense ..
  16. Desveaux D, Singer A, Wu A, McNulty B, Musselwhite L, Nimchuk Z, et al. Type III effector activation via nucleotide binding, phosphorylation, and host target interaction. PLoS Pathog. 2007;3:e48 pubmed publisher
    ..III effector protein avirulence protein B (AvrB) is delivered into plant cells, where it targets the Arabidopsis RIN4 protein (resistance to Pseudomonas maculicula protein 1 [RPM1]-interacting protein)...
  17. Elmore J, Liu J, Smith B, Phinney B, Coaker G. Quantitative proteomics reveals dynamic changes in the plasma membrane during Arabidopsis immune signaling. Mol Cell Proteomics. 2012;11:M111.014555 pubmed publisher
    ..This study presents the largest quantitative proteomics data set of plant immunity to date and provides a framework for understanding global plasma membrane proteome dynamics during plant immune responses. ..
  18. Chung E, El Kasmi F, He Y, Loehr A, Dangl J. A plant phosphoswitch platform repeatedly targeted by type III effector proteins regulates the output of both tiers of plant immune receptors. Cell Host Microbe. 2014;16:484-94 pubmed publisher
    ..Immune detection is suppressed by equally complex pathogen mechanisms. The small plasma-membrane-tethered protein RIN4 negatively regulates microbe-associated molecular pattern (MAMP)-triggered responses, which are derepressed upon ..