RGS1

Summary

Gene Symbol: RGS1
Description: REGULATOR OF G-PROTEIN SIGNALING 1
Alias: ATRGS1, REGULATOR OF G-PROTEIN SIGNALING 1, REGULATOR OF G-PROTEIN SIGNALING 1
Species: thale cress

Top Publications

  1. Chen J, Willard F, Huang J, Liang J, Chasse S, Jones A, et al. A seven-transmembrane RGS protein that modulates plant cell proliferation. Science. 2003;301:1728-31 pubmed
    ..Here we identified an RGS protein (AtRGS1) in Arabidopsis that has a predicted structure similar to a GPCR as well as an RGS box with GTPase accelerating ..
  2. Johnston C, Taylor J, Gao Y, Kimple A, Grigston J, Chen J, et al. GTPase acceleration as the rate-limiting step in Arabidopsis G protein-coupled sugar signaling. Proc Natl Acad Sci U S A. 2007;104:17317-22 pubmed
    ..b>AtRGS1 is a seven-transmembrane, RGS domain-containing protein that is a putative membrane receptor for d-glucose...
  3. Chen J, Jones A. AtRGS1 function in Arabidopsis thaliana. Methods Enzymol. 2004;389:338-50 pubmed
    Arabidopsis thaliana RGS1 is a novel "regulator of G-protein signaling" (AtRGS1) protein that consists of an N-terminal seven transmembrane domain characteristic of G-protein-coupled receptors and a C-terminal RGS box...
  4. Mudgil Y, Uhrig J, Zhou J, Temple B, Jiang K, Jones A. Arabidopsis N-MYC DOWNREGULATED-LIKE1, a positive regulator of auxin transport in a G protein-mediated pathway. Plant Cell. 2009;21:3591-609 pubmed publisher
    ..AGB1, auxin, and sugars are required for NDL1 protein stability in regions of the root where auxin gradients are established; thus, the signaling mechanism contains feedback loops. ..
  5. Jones J, Temple B, Jones A, Dohlman H. Functional reconstitution of an atypical G protein heterotrimer and regulator of G protein signaling protein (RGS1) from Arabidopsis thaliana. J Biol Chem. 2011;286:13143-50 pubmed publisher
    ..It is unknown how AtGPA1 is regulated by G?? and the RGS (regulator of G protein signaling) protein AtRGS1, which is comprised of an RGS domain fused to a receptor-like domain...
  6. Grigston J, Osuna D, Scheible W, Liu C, Stitt M, Jones A. D-Glucose sensing by a plasma membrane regulator of G signaling protein, AtRGS1. FEBS Lett. 2008;582:3577-84 pubmed publisher
    ..The Arabidopsis thaliana regulator of G-protein signaling protein 1 (AtRGS1) combines a receptor-like seven transmembrane domain with an RGS domain, interacts with the Arabidopsis Galpha ..
  7. Willard F, Siderovski D. Purification and in vitro functional analysis of the Arabidopsis thaliana regulator of G-protein signaling-1. Methods Enzymol. 2004;389:320-38 pubmed
    ..thaliana genome, regulator of G-protein signaling-1 (AtRGS1)...
  8. Fan L, Zhang W, Chen J, Taylor J, Jones A, Assmann S. Abscisic acid regulation of guard-cell K+ and anion channels in Gbeta- and RGS-deficient Arabidopsis lines. Proc Natl Acad Sci U S A. 2008;105:8476-81 pubmed publisher
    ..harboring mutations in the sole Arabidopsis Galpha (AtGPA1), Gbeta (AGB1), and Regulator of G protein Signaling (AtRGS1) genes for impacts on ion channel regulation...
  9. Tunc Ozdemir M, Urano D, Jaiswal D, Clouse S, Jones A. Direct Modulation of Heterotrimeric G Protein-coupled Signaling by a Receptor Kinase Complex. J Biol Chem. 2016;291:13918-25 pubmed publisher
    ..In Arabidopsis, the sole 7-transmembrane regulator of G protein signaling 1 (AtRGS1) modulates the G protein complex by keeping it in the resting state (GDP-bound)...
  10. Tunc Ozdemir M, Jones A. BRL3 and AtRGS1 cooperate to fine tune growth inhibition and ROS activation. PLoS ONE. 2017;12:e0177400 pubmed publisher
    ..activates G protein complex via interaction with seven transmembrane domain Regulator of G-protein Signaling 1 (AtRGS1) protein. Brassinosteroid insensitive 1 (BRI1) LIKE3 (BRL3) phosphorylates AtRGS1 in vitro...

Detail Information

Publications15

  1. Chen J, Willard F, Huang J, Liang J, Chasse S, Jones A, et al. A seven-transmembrane RGS protein that modulates plant cell proliferation. Science. 2003;301:1728-31 pubmed
    ..Here we identified an RGS protein (AtRGS1) in Arabidopsis that has a predicted structure similar to a GPCR as well as an RGS box with GTPase accelerating ..
  2. Johnston C, Taylor J, Gao Y, Kimple A, Grigston J, Chen J, et al. GTPase acceleration as the rate-limiting step in Arabidopsis G protein-coupled sugar signaling. Proc Natl Acad Sci U S A. 2007;104:17317-22 pubmed
    ..b>AtRGS1 is a seven-transmembrane, RGS domain-containing protein that is a putative membrane receptor for d-glucose...
  3. Chen J, Jones A. AtRGS1 function in Arabidopsis thaliana. Methods Enzymol. 2004;389:338-50 pubmed
    Arabidopsis thaliana RGS1 is a novel "regulator of G-protein signaling" (AtRGS1) protein that consists of an N-terminal seven transmembrane domain characteristic of G-protein-coupled receptors and a C-terminal RGS box...
  4. Mudgil Y, Uhrig J, Zhou J, Temple B, Jiang K, Jones A. Arabidopsis N-MYC DOWNREGULATED-LIKE1, a positive regulator of auxin transport in a G protein-mediated pathway. Plant Cell. 2009;21:3591-609 pubmed publisher
    ..AGB1, auxin, and sugars are required for NDL1 protein stability in regions of the root where auxin gradients are established; thus, the signaling mechanism contains feedback loops. ..
  5. Jones J, Temple B, Jones A, Dohlman H. Functional reconstitution of an atypical G protein heterotrimer and regulator of G protein signaling protein (RGS1) from Arabidopsis thaliana. J Biol Chem. 2011;286:13143-50 pubmed publisher
    ..It is unknown how AtGPA1 is regulated by G?? and the RGS (regulator of G protein signaling) protein AtRGS1, which is comprised of an RGS domain fused to a receptor-like domain...
  6. Grigston J, Osuna D, Scheible W, Liu C, Stitt M, Jones A. D-Glucose sensing by a plasma membrane regulator of G signaling protein, AtRGS1. FEBS Lett. 2008;582:3577-84 pubmed publisher
    ..The Arabidopsis thaliana regulator of G-protein signaling protein 1 (AtRGS1) combines a receptor-like seven transmembrane domain with an RGS domain, interacts with the Arabidopsis Galpha ..
  7. Willard F, Siderovski D. Purification and in vitro functional analysis of the Arabidopsis thaliana regulator of G-protein signaling-1. Methods Enzymol. 2004;389:320-38 pubmed
    ..thaliana genome, regulator of G-protein signaling-1 (AtRGS1)...
  8. Fan L, Zhang W, Chen J, Taylor J, Jones A, Assmann S. Abscisic acid regulation of guard-cell K+ and anion channels in Gbeta- and RGS-deficient Arabidopsis lines. Proc Natl Acad Sci U S A. 2008;105:8476-81 pubmed publisher
    ..harboring mutations in the sole Arabidopsis Galpha (AtGPA1), Gbeta (AGB1), and Regulator of G protein Signaling (AtRGS1) genes for impacts on ion channel regulation...
  9. Tunc Ozdemir M, Urano D, Jaiswal D, Clouse S, Jones A. Direct Modulation of Heterotrimeric G Protein-coupled Signaling by a Receptor Kinase Complex. J Biol Chem. 2016;291:13918-25 pubmed publisher
    ..In Arabidopsis, the sole 7-transmembrane regulator of G protein signaling 1 (AtRGS1) modulates the G protein complex by keeping it in the resting state (GDP-bound)...
  10. Tunc Ozdemir M, Jones A. BRL3 and AtRGS1 cooperate to fine tune growth inhibition and ROS activation. PLoS ONE. 2017;12:e0177400 pubmed publisher
    ..activates G protein complex via interaction with seven transmembrane domain Regulator of G-protein Signaling 1 (AtRGS1) protein. Brassinosteroid insensitive 1 (BRI1) LIKE3 (BRL3) phosphorylates AtRGS1 in vitro...
  11. Chen Y, Ji F, Xie H, Liang J. Overexpression of the regulator of G-protein signalling protein enhances ABA-mediated inhibition of root elongation and drought tolerance in Arabidopsis. J Exp Bot. 2006;57:2101-10 pubmed
    ..In the experiments reported here, the overexpression approach was used to present evidence that RGS1 protein plays critical roles in plant development and in modulating abscisic acid (ABA) and drought stress signal ..
  12. Booker K, Schwarz J, Garrett M, Jones A. Glucose attenuation of auxin-mediated bimodality in lateral root formation is partly coupled by the heterotrimeric G protein complex. PLoS ONE. 2010;5: pubmed publisher
    ..beta (AGB1), and gamma (AGG) subunits and a GTPase accelerating protein called Regulator of G Signaling 1 protein (AtRGS1), are involved in glucose signaling and regulate auxin transport...
  13. Urano D, Phan N, Jones J, Yang J, Huang J, GRIGSTON J, et al. Endocytosis of the seven-transmembrane RGS1 protein activates G-protein-coupled signalling in Arabidopsis. Nat Cell Biol. 2012;14:1079-88 pubmed publisher
    ..G? protein self-activates without accessory proteins, and is kept in its resting state by the negative regulator, AtRGS1 (regulator of G-protein signalling 1), which is the prototype of a seven-transmembrane receptor fused with an RGS ..
  14. Huang P, Yeh H, Yi H, Lin C, Yang C. Fluorescence-based assay probing regulator of G protein signaling partner proteins. Anal Biochem. 2012;423:133-40 pubmed publisher
    ..We present a method for real-time examination of the protein-protein interactions between RGS and G? subunits. AtRGS1 from plants and RGS4 from mammals were site-directedly labeled with the fluorescent probe Lucifer yellow on ..
  15. Huang J, Tunc Ozdemir M, Chang Y, Jones A. Cooperative control between AtRGS1 and AtHXK1 in a WD40-repeat protein pathway in Arabidopsis thaliana. Front Plant Sci. 2015;6:851 pubmed publisher
    HEXOKINASE 1 (AtHXK1) and Regulator of G-protein Signaling 1 (AtRGS1) pathways, mediate D-glucose signaling in Arabidopsis. However, it is not known the degree, if any, that these pathways overlap and how...