Genomes and Genes
Gene Symbol: RD21A
Description: Granulin repeat cysteine protease family protein
Alias: F2G19.31, F2G19_31, RD21, RESPONSIVE TO DEHYDRATION 21A, responsive to dehydration 21, responsive to dehydration 21A, Granulin repeat cysteine protease family protein
Species: thale cress
- Zhang B, Tremousaygue D, Denancé N, van Esse H, Hörger A, Dabos P, et al. PIRIN2 stabilizes cysteine protease XCP2 and increases susceptibility to the vascular pathogen Ralstonia solanacearum in Arabidopsis. Plant J. 2014;79:1009-19 pubmed publisher..molecular mechanism by analyzing PRN2 interactions with the papain-like cysteine proteases (PLCPs) XCP2, RD21A, and RD21B, all of which bound to PRN2 in yeast two-hybrid assays and in Arabidopsis protoplast co-..
- Rustgi S, Boex Fontvieille E, Reinbothe C, von Wettstein D, Reinbothe S. Serpin1 and WSCP differentially regulate the activity of the cysteine protease RD21 during plant development in Arabidopsis thaliana. Proc Natl Acad Sci U S A. 2017;114:2212-2217 pubmed publisher..an example of how nature evolved alternative mechanisms to fine-tune the activity of a cysteine protease dubbed RD21 (RESPONSIVE TO DESICCATION-21)...
- Lampl N, Alkan N, Davydov O, Fluhr R. Set-point control of RD21 protease activity by AtSerpin1 controls cell death in Arabidopsis. Plant J. 2013;74:498-510 pubmed publisher..serpin protease inhibitor, AtSerpin1, exhibits a pro-survival function by inhibiting its target pro-death protease, RD21. AtSerpin1 accumulates in the cytoplasm and RD21 accumulates in the vacuole and in endoplasmic reticulum bodies...
- Boex Fontvieille E, Rustgi S, Reinbothe S, Reinbothe C. A Kunitz-type protease inhibitor regulates programmed cell death during flower development in Arabidopsis thaliana. J Exp Bot. 2015;66:6119-35 pubmed publisher..thaliana. Genetic, biochemical, and cell biology approaches revealed that WSCP physically interacts with RD21 (RESPONSIVE TO DESICCATION) and that this interaction in turn inhibits the activity of RD21 as a pro-death protein...