Gene Symbol: RCN1
Description: ARM repeat superfamily protein
Species: thale cress

Top Publications

  1. Muday G, Brady S, Argueso C, Deruère J, Kieber J, DeLong A. RCN1-regulated phosphatase activity and EIN2 modulate hypocotyl gravitropism by a mechanism that does not require ethylene signaling. Plant Physiol. 2006;141:1617-29 pubmed
    The roots curl in naphthylphthalamic acid1 (rcn1) mutant of Arabidopsis (Arabidopsis thaliana) has altered auxin transport, gravitropism, and ethylene response, providing an opportunity to analyze the interplay between ethylene and auxin ..
  2. Blakeslee J, Zhou H, Heath J, Skottke K, Barrios J, Liu S, et al. Specificity of RCN1-mediated protein phosphatase 2A regulation in meristem organization and stress response in roots. Plant Physiol. 2008;146:539-53 pubmed
    ..Characterization of the regulatory A subunit isoforms (ROOTS CURL IN NAPHTHYLPHTHALAMIC ACID1 [RCN1], PP2AA2, and PP2AA3) of Arabidopsis thaliana PP2A has shown that RCN1 plays a primary role in controlling root and ..
  3. Rashotte A, DeLong A, Muday G. Genetic and chemical reductions in protein phosphatase activity alter auxin transport, gravity response, and lateral root growth. Plant Cell. 2001;13:1683-97 pubmed
    ..Several lines of evidence suggest that reversible protein phosphorylation regulates auxin transport. Arabidopsis rcn1 mutant seedlings exhibit reduced protein phosphatase 2A activity and defects in differential cell elongation...
  4. Tseng T, Briggs W. The Arabidopsis rcn1-1 mutation impairs dephosphorylation of Phot2, resulting in enhanced blue light responses. Plant Cell. 2010;22:392-402 pubmed publisher
    ..Phenotypic characterizations of a phot1-5 rcn1-1 (for root curling in n-naphthylphthalamic acid1) double mutant, in which phot2 is the only functional phototropin ..
  5. Dai M, Zhang C, Kania U, Chen F, Xue Q, McCray T, et al. A PP6-type phosphatase holoenzyme directly regulates PIN phosphorylation and auxin efflux in Arabidopsis. Plant Cell. 2012;24:2497-514 pubmed publisher
    ..biochemical, and genetic data support the notion that FyPP1/3, SAL (for SAPS DOMAIN-LIKE), and PP2AA proteins (RCN1 [for ROOTS CURL IN NAPHTHYLPHTHALAMIC ACID1] or PP2AA1, PP2AA2, and PP2AA3) physically interact to form a novel PP6-..
  6. Larsen P, Chang C. The Arabidopsis eer1 mutant has enhanced ethylene responses in the hypocotyl and stem. Plant Physiol. 2001;125:1061-73 pubmed
    By screening for enhanced ethylene-response (eer) mutants in Arabidopsis, we isolated a novel recessive mutant, eer1, which displays increased ethylene sensitivity in the hypocotyl and stem...
  7. Demarsy E, Schepens I, Okajima K, Hersch M, Bergmann S, Christie J, et al. Phytochrome Kinase Substrate 4 is phosphorylated by the phototropin 1 photoreceptor. EMBO J. 2012;31:3457-67 pubmed publisher
    ..Our physiological analyses suggest that PKS4 phosphorylation is not essential for phototropism but is part of a negative feedback mechanism. ..
  8. Luo J, Shen G, Yan J, He C, Zhang H. AtCHIP functions as an E3 ubiquitin ligase of protein phosphatase 2A subunits and alters plant response to abscisic acid treatment. Plant J. 2006;46:649-57 pubmed
    ..Unlike the rcn1 mutant, that has reduced PP2A activity due to a mutation in one of the A subunit genes of PP2A, AtCHIP-..
  9. Karampelias M, Neyt P, De Groeve S, Aesaert S, Coussens G, Rolčík J, et al. ROTUNDA3 function in plant development by phosphatase 2A-mediated regulation of auxin transporter recycling. Proc Natl Acad Sci U S A. 2016;113:2768-73 pubmed publisher
    ..pharmacological interference with vesicle trafficking processes revealed that single ron3-2 and double ron3-2 rcn1 mutants have altered PIN polarity and endocytosis in specific cells...

More Information


  1. Tang W, Yuan M, Wang R, Yang Y, Wang C, Oses Prieto J, et al. PP2A activates brassinosteroid-responsive gene expression and plant growth by dephosphorylating BZR1. Nat Cell Biol. 2011;13:124-31 pubmed publisher
  2. Jackson K, Soll D. Mutations in a new Arabidopsis cyclophilin disrupt its interaction with protein phosphatase 2A. Mol Gen Genet. 1999;262:830-8 pubmed
    ..These results indicate that cyclophilin may have a role in regulating PP2A activity, by a mechanism that differs from that employed for cyclophilin regulation of PP2B. ..
  3. Saito N, Munemasa S, Nakamura Y, Shimoishi Y, Mori I, Murata Y. Roles of RCN1, regulatory A subunit of protein phosphatase 2A, in methyl jasmonate signaling and signal crosstalk between methyl jasmonate and abscisic acid. Plant Cell Physiol. 2008;49:1396-401 pubmed publisher
    ..We investigated the function of a regulatory A subunit of protein phosphatase 2A, RCN1, in MeJA signaling...
  4. Tran H, Nimick M, Uhrig R, Templeton G, Morrice N, Gourlay R, et al. Arabidopsis thaliana histone deacetylase 14 (HDA14) is an ?-tubulin deacetylase that associates with PP2A and enriches in the microtubule fraction with the putative histone acetyltransferase ELP3. Plant J. 2012;71:263-72 pubmed publisher
    ..The association of a histone deacetylase with PP2A suggests a direct link between protein phosphorylation and acetylation. ..
  5. Kwak J, Moon J, Murata Y, Kuchitsu K, Leonhardt N, DeLong A, et al. Disruption of a guard cell-expressed protein phosphatase 2A regulatory subunit, RCN1, confers abscisic acid insensitivity in Arabidopsis. Plant Cell. 2002;14:2849-61 pubmed
    ..A guard cell-expressed PP2A gene, RCN1, which had been characterized previously as a molecular component affecting auxin transport and gravity response, ..
  6. Camilleri C, Azimzadeh J, Pastuglia M, Bellini C, Grandjean O, Bouchez D. The Arabidopsis TONNEAU2 gene encodes a putative novel protein phosphatase 2A regulatory subunit essential for the control of the cortical cytoskeleton. Plant Cell. 2002;14:833-45 pubmed
  7. Yang Z, Guo G, Zhang M, Liu C, Hu Q, Lam H, et al. Stable isotope metabolic labeling-based quantitative phosphoproteomic analysis of Arabidopsis mutants reveals ethylene-regulated time-dependent phosphoproteins and putative substrates of constitutive triple response 1 kinase. Mol Cell Proteomics. 2013;12:3559-82 pubmed publisher
    ..was performed on both one-minute ethylene-treated Arabidopsis ethylene-overly-sensitive loss-of-function mutant rcn1-1, deficient in PP2A phosphatase activity, and a pair of long-term ethylene-treated wild-type and loss-of-function ..
  8. Haynes J, Hartung A, Hendershot J, Passingham R, Rundle S. Molecular characterization of the B' regulatory subunit gene family of Arabidopsis protein phosphatase 2A. Eur J Biochem. 1999;260:127-36 pubmed
  9. Garbers C, DeLong A, Deruère J, Bernasconi P, Soll D. A mutation in protein phosphatase 2A regulatory subunit A affects auxin transport in Arabidopsis. EMBO J. 1996;15:2115-24 pubmed
    ..We have isolated a novel Arabidopsis thaliana mutant designated roots curl in NPA (rcn1). Mutant seedlings exhibit altered responses to NPA in root curling and hypocotyl elongation...