RCAR3

Summary

Gene Symbol: RCAR3
Description: regulatory components of ABA receptor 3
Alias: MFH8.10, MFH8_10, PYL8, PYR1-like 8, regulatory components of ABA receptor 3, regulatory components of ABA receptor 3
Species: thale cress

Top Publications

  1. Santiago J, Rodrigues A, Saez A, Rubio S, Antoni R, Dupeux F, et al. Modulation of drought resistance by the abscisic acid receptor PYL5 through inhibition of clade A PP2Cs. Plant J. 2009;60:575-88 pubmed publisher
    ..Three proteins were identified, PYL5, PYL6 and PYL8, which belong to a 14-member subfamily of the Bet v1-like superfamily...
  2. Szostkiewicz I, Richter K, Kepka M, Demmel S, Ma Y, Korte A, et al. Closely related receptor complexes differ in their ABA selectivity and sensitivity. Plant J. 2010;61:25-35 pubmed publisher
    ..In this study we characterize a novel member of the RCAR family, RCAR3. RCAR3 was identified in a screen for interactors of the PP2Cs ABI1 and ABI2, which are key regulators of ABA ..
  3. Park S, Fung P, Nishimura N, Jensen D, Fujii H, Zhao Y, et al. Abscisic acid inhibits type 2C protein phosphatases via the PYR/PYL family of START proteins. Science. 2009;324:1068-71 pubmed publisher
    ..Our results illustrate the power of the chemical genetic approach for sidestepping genetic redundancy. ..
  4. Ma Y, Szostkiewicz I, Korte A, Moes D, Yang Y, Christmann A, et al. Regulators of PP2C phosphatase activity function as abscisic acid sensors. Science. 2009;324:1064-8 pubmed publisher
    ..Other RCARs also mediated ABA-dependent regulation of ABI1 and ABI2, consistent with a combinatorial assembly of receptor complexes. ..
  5. Dupeux F, Santiago J, Betz K, Twycross J, Park S, Rodriguez L, et al. A thermodynamic switch modulates abscisic acid receptor sensitivity. EMBO J. 2011;30:4171-84 pubmed publisher
    ..This work illustrates how receptor oligomerization can modulate hormonal responses and more generally, the sensitivity of a ligand-dependent signalling system. ..
  6. Bhaskara G, Nguyen T, Verslues P. Unique drought resistance functions of the highly ABA-induced clade A protein phosphatase 2Cs. Plant Physiol. 2012;160:379-95 pubmed publisher
    ..Both this and their distinct PYL interaction demonstrate a new level of functional differentiation among the clade A PP2Cs and a point of cross talk between ABA-dependent and ABA-independent drought-associated signaling. ..
  7. Lee S, Lim C, Lan W, He K, Luan S. ABA signaling in guard cells entails a dynamic protein-protein interaction relay from the PYL-RCAR family receptors to ion channels. Mol Plant. 2013;6:528-38 pubmed publisher
    ..Further study using transgenic plants overexpressing one of the ABA receptors demonstrated that changing the relative level of interacting partners would change ABA sensitivity. ..
  8. Li Y, Zhang L, Li D, Liu Z, Wang J, Li X, et al. The Arabidopsis F-box E3 ligase RIFP1 plays a negative role in abscisic acid signalling by facilitating ABA receptor RCAR3 degradation. Plant Cell Environ. 2016;39:571-82 pubmed publisher
    ..Here, we report that an Arabidopsis thaliana F-box protein RCAR3 INTERACTING F-BOX PROTEIN 1 (RIFP1) interacts with ABA receptor (RCAR3) and SCF E3 ligase complex subunits ..
  9. Zhao Y, Chan Z, Xing L, Liu X, Hou Y, Chinnusamy V, et al. The unique mode of action of a divergent member of the ABA-receptor protein family in ABA and stress signaling. Cell Res. 2013;23:1380-95 pubmed publisher
    ..Our results show that PYL13 is not an ABA receptor but can modulate the ABA pathway by interacting with and inhibiting both the PYL receptors and the PP2C co-receptors...

More Information

Publications19

  1. Lim C, Kim J, Baek W, Kim B, Lee S. Functional roles of the protein phosphatase 2C, AtAIP1, in abscisic acid signaling and sugar tolerance in Arabidopsis. Plant Sci. 2012;187:83-8 pubmed publisher
    ..Taken together, these results demonstrated that AIP1 is associated with ABA-mediated cell signaling and function as positive regulators of ABA. ..
  2. Zhang X, Jiang L, Wang G, Yu L, Zhang Q, Xin Q, et al. Structural insights into the abscisic acid stereospecificity by the ABA receptors PYR/PYL/RCAR. PLoS ONE. 2013;8:e67477 pubmed publisher
    ..Our results provide novel insights of the bioactivity of ABA enantiomers onto PYLs, and shed light on designing the selective ABA receptors agonists. ..
  3. Irigoyen M, Iniesto E, Rodriguez L, Puga M, Yanagawa Y, Pick E, et al. Targeted degradation of abscisic acid receptors is mediated by the ubiquitin ligase substrate adaptor DDA1 in Arabidopsis. Plant Cell. 2014;26:712-28 pubmed publisher
    ..Thus, we show that DDA1 binds to the abscisic acid (ABA) receptor PYL8, as well as PYL4 and PYL9, in vivo and facilitates its proteasomal degradation...
  4. Lee H, Lee K, Kim C. Abscisic acid receptor PYRABACTIN RESISTANCE-LIKE 8, PYL8, is involved in glucose response and dark-induced leaf senescence in Arabidopsis. Biochem Biophys Res Commun. 2015;463:24-8 pubmed publisher
    ..In this study, we investigated the effect of the disruption and overexpression of an ABA receptor gene, PYL8 (At5g53160) on plant responses to glucose (Glc) and dark-induced leaf senescence...
  5. Zhao Y, Xing L, Wang X, Hou Y, Gao J, Wang P, et al. The ABA receptor PYL8 promotes lateral root growth by enhancing MYB77-dependent transcription of auxin-responsive genes. Sci Signal. 2014;7:ra53 pubmed publisher
    ..by a group of receptors known as the PYR1/PYL/RCAR family, which includes the pyrabactin resistance 1-like protein PYL8. Under stress conditions, ABA signaling activates SnRK2 protein kinases to inhibit lateral root growth after ..
  6. Nishimura N, Sarkeshik A, Nito K, Park S, Wang A, Carvalho P, et al. PYR/PYL/RCAR family members are major in-vivo ABI1 protein phosphatase 2C-interacting proteins in Arabidopsis. Plant J. 2010;61:290-9 pubmed publisher
  7. Rodriguez L, Gonzalez Guzman M, Díaz M, Rodrigues A, Izquierdo Garcia A, Peirats Llobet M, et al. C2-domain abscisic acid-related proteins mediate the interaction of PYR/PYL/RCAR abscisic acid receptors with the plasma membrane and regulate abscisic acid sensitivity in Arabidopsis. Plant Cell. 2014;26:4802-20 pubmed publisher
    ..In summary, we identified PYR/PYL-interacting partners that mediate a transient Ca(2+)-dependent interaction with phospholipid vesicles, which affects PYR/PYL subcellular localization and positively regulates ABA signaling. ..
  8. Xing L, Zhao Y, Gao J, Xiang C, Zhu J. The ABA receptor PYL9 together with PYL8 plays an important role in regulating lateral root growth. Sci Rep. 2016;6:27177 pubmed publisher
    ..Exogenous ABA induces growth quiescence of lateral roots, which is prolonged by knockout of the ABA receptor PYL8. Among the 14 members of PYR1/PYL/RCAR protein family, PYL9 is a close relative of PYL8...
  9. Antoni R, Gonzalez Guzman M, Rodriguez L, Peirats Llobet M, Pizzio G, Fernandez M, et al. PYRABACTIN RESISTANCE1-LIKE8 plays an important role for the regulation of abscisic acid signaling in root. Plant Physiol. 2013;161:931-41 pubmed publisher
    ..As a result, we discovered that PYL8 plays a nonredundant role for the regulation of root ABA sensitivity...
  10. Saavedra X, Modrego A, Rodriguez D, González García M, Sanz L, Nicolás G, et al. The nuclear interactor PYL8/RCAR3 of Fagus sylvatica FsPP2C1 is a positive regulator of abscisic acid signaling in seeds and stress. Plant Physiol. 2010;152:133-50 pubmed publisher
    ..Two closely related members (PYL8/RCAR3 and PYL7/RCAR2) of the Arabidopsis (Arabidopsis thaliana) BetV I family were shown to bind FsPP2C1 in a yeast two-..