Gene Symbol: RCAR1
Description: regulatory component of ABA receptor 1
Alias: F6F3.16, F6F3_16, PYL9, PYRABACTIN RESISTANCE 1-LIKE 9, regulatory component of ABA receptor 1, regulatory component of ABA receptor 1
Species: thale cress

Top Publications

  1. Ma Y, Szostkiewicz I, Korte A, Moes D, Yang Y, Christmann A, et al. Regulators of PP2C phosphatase activity function as abscisic acid sensors. Science. 2009;324:1064-8 pubmed publisher
    ..b>RCAR1 was shown to bind ABA, to mediate ABA-dependent inactivation of ABI1 or ABI2 in vitro, and to antagonize PP2C ..
  2. Park S, Fung P, Nishimura N, Jensen D, Fujii H, Zhao Y, et al. Abscisic acid inhibits type 2C protein phosphatases via the PYR/PYL family of START proteins. Science. 2009;324:1068-71 pubmed publisher
    ..Our results illustrate the power of the chemical genetic approach for sidestepping genetic redundancy. ..
  3. Merilo E, Laanemets K, Hu H, Xue S, Jakobson L, Tulva I, et al. PYR/RCAR receptors contribute to ozone-, reduced air humidity-, darkness-, and CO2-induced stomatal regulation. Plant Physiol. 2013;162:1652-68 pubmed publisher
    ..Thus, we show that PYR/RCAR receptors play an important role for the whole-plant stomatal adjustments and responses to low humidity, darkness, and O3 and are involved in responses to elevated CO2. ..
  4. Zhao Y, Chan Z, Gao J, Xing L, Cao M, Yu C, et al. ABA receptor PYL9 promotes drought resistance and leaf senescence. Proc Natl Acad Sci U S A. 2016;113:1949-54 pubmed publisher
    ..resistance 1-like (PYL) abscisic acid (ABA) receptor gene combinations and discovered that pRD29A::PYL9 transgenic lines showed dramatically increased drought resistance and drought-induced leaf senescence in both ..
  5. Li Z, Li Z, Gao X, Chinnusamy V, Bressan R, Wang Z, et al. ROP11 GTPase negatively regulates ABA signaling by protecting ABI1 phosphatase activity from inhibition by the ABA receptor RCAR1/PYL9 in Arabidopsis. J Integr Plant Biol. 2012;54:180-8 pubmed publisher
    ..The current work demonstrated that the constitutively active ROP11 (CA-ROP11) can modulate the RCAR1/PYL9-mediated ABA signaling pathway based on reconstitution assays in Arabidopsis thaliana protoplasts...
  6. Bhaskara G, Nguyen T, Verslues P. Unique drought resistance functions of the highly ABA-induced clade A protein phosphatase 2Cs. Plant Physiol. 2012;160:379-95 pubmed publisher
    ..Both this and their distinct PYL interaction demonstrate a new level of functional differentiation among the clade A PP2Cs and a point of cross talk between ABA-dependent and ABA-independent drought-associated signaling. ..
  7. Shibata N, Kagiyama M, Nakagawa M, Hirano Y, Hakoshima T. Crystallization of the plant hormone receptors PYL9/RCAR1, PYL5/RCAR8 and PYR1/RCAR11 in the presence of (+)-abscisic acid. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2010;66:456-9 pubmed publisher
    ..purification, crystallization and X-ray data collection are reported for a member of each of the subfamilies, PYL9/RCAR1 from subfamily I, PYL5/RCAR8 from subfamily II and PYR1/RCAR11 from subfamily III, in the presence of (+)-abscisic ..
  8. Nishimura N, Sarkeshik A, Nito K, Park S, Wang A, Carvalho P, et al. PYR/PYL/RCAR family members are major in-vivo ABI1 protein phosphatase 2C-interacting proteins in Arabidopsis. Plant J. 2010;61:290-9 pubmed publisher
  9. Lee S, Lim C, Lan W, He K, Luan S. ABA signaling in guard cells entails a dynamic protein-protein interaction relay from the PYL-RCAR family receptors to ion channels. Mol Plant. 2013;6:528-38 pubmed publisher
    ..Further study using transgenic plants overexpressing one of the ABA receptors demonstrated that changing the relative level of interacting partners would change ABA sensitivity. ..

More Information


  1. Xing L, Zhao Y, Gao J, Xiang C, Zhu J. The ABA receptor PYL9 together with PYL8 plays an important role in regulating lateral root growth. Sci Rep. 2016;6:27177 pubmed publisher
    ..Among the 14 members of PYR1/PYL/RCAR protein family, PYL9 is a close relative of PYL8...
  2. Zhao Y, Chan Z, Xing L, Liu X, Hou Y, Chinnusamy V, et al. The unique mode of action of a divergent member of the ABA-receptor protein family in ABA and stress signaling. Cell Res. 2013;23:1380-95 pubmed publisher
    ..Our results show that PYL13 is not an ABA receptor but can modulate the ABA pathway by interacting with and inhibiting both the PYL receptors and the PP2C co-receptors...
  3. Irigoyen M, Iniesto E, Rodriguez L, Puga M, Yanagawa Y, Pick E, et al. Targeted degradation of abscisic acid receptors is mediated by the ubiquitin ligase substrate adaptor DDA1 in Arabidopsis. Plant Cell. 2014;26:712-28 pubmed publisher
    ..Thus, we show that DDA1 binds to the abscisic acid (ABA) receptor PYL8, as well as PYL4 and PYL9, in vivo and facilitates its proteasomal degradation...
  4. Ye Y, Zhou L, Liu X, Liu H, Li D, Cao M, et al. A Novel Chemical Inhibitor of ABA Signaling Targets All ABA Receptors. Plant Physiol. 2017;173:2356-2369 pubmed publisher
  5. Zhang X, Jiang L, Wang G, Yu L, Zhang Q, Xin Q, et al. Structural insights into the abscisic acid stereospecificity by the ABA receptors PYR/PYL/RCAR. PLoS ONE. 2013;8:e67477 pubmed publisher
    ..the affinity of PYLs binding to the (-)-ABA and reported the crystal structures of apo-PYL5, PYL3-(-)-ABA and PYL9-(+)-ABA. PYL5 showed the strongest binding affinity with (-)-ABA among all the PYLs...
  6. Li Z, Waadt R, Schroeder J. Release of GTP Exchange Factor Mediated Down-Regulation of Abscisic Acid Signal Transduction through ABA-Induced Rapid Degradation of RopGEFs. PLoS Biol. 2016;14:e1002461 pubmed publisher
  7. Sun H, Wang X, Ding W, Zhu S, Zhao R, Zhang Y, et al. Identification of an important site for function of the type 2C protein phosphatase ABI2 in abscisic acid signalling in Arabidopsis. J Exp Bot. 2011;62:5713-25 pubmed publisher
    ..in the ABI2 molecule is required for the interactions of ABI2 with the two members of the ABA receptors PYL5 and PYL9 and with a downstream protein kinase SnRK2...
  8. Nakagawa M, Kagiyama M, Shibata N, Hirano Y, Hakoshima T. Mechanism of high-affinity abscisic acid binding to PYL9/RCAR1. Genes Cells. 2014;19:386-404 pubmed publisher
    ..Comparative structural and binding studies between PYL9, which is a representative of high-affinity subfamily I, and low-affinity members of subfamily III reveals that the ..