RBX1

Summary

Gene Symbol: RBX1
Description: RING-box 1
Alias: ATRBX1, F7C8.160, F7C8_160, HRT1, REGULATOR OF CULLINS-1, RING-BOX 1, RING-box 1, ROC1, RING-box 1
Species: thale cress

Top Publications

  1. Mori Y, Hayashi M, Nishimura M, Yamamoto K. A new temperature-insensitive allele of the Arabidopsis AXR6/CUL1 locus derived from a missense mutation in the C-terminal RBX1 binding region. Plant Signal Behav. 2015;10:e1078956 pubmed publisher
    ..of the CUL1 protein, which is likely to affect its ability to bind to the C-terminal RING domain of RING-box 1 (RBX1)...
  2. Dieterle M, Thomann A, Renou J, Parmentier Y, Cognat V, Lemonnier G, et al. Molecular and functional characterization of Arabidopsis Cullin 3A. Plant J. 2005;41:386-99 pubmed
    ..We found that CUL3A is ubiquitously expressed in plants and is able to interact with the ring-finger protein RBX1. A genomic search revealed the existence of at least 76 BTB-domain proteins in Arabidopsis belonging to 11 major ..
  3. Ren C, Pan J, Peng W, Genschik P, Hobbie L, Hellmann H, et al. Point mutations in Arabidopsis Cullin1 reveal its essential role in jasmonate response. Plant J. 2005;42:514-24 pubmed
    ..Furthermore, we show that the point mutations in AtCUL1 affect the assembly of COI1 into SCF, thus attenuating SCF(COI1) formation. ..
  4. Han L, Mason M, Risseeuw E, Crosby W, Somers D. Formation of an SCF(ZTL) complex is required for proper regulation of circadian timing. Plant J. 2004;40:291-301 pubmed
    ..of full-length (FL) ZTL with the three known core components of SCF complexes (ASK1, AtCUL1 and AtRBX1) demonstrates that ZTL can assemble into an SCF complex in vivo...
  5. Bernhardt A, Lechner E, Hano P, Schade V, Dieterle M, Anders M, et al. CUL4 associates with DDB1 and DET1 and its downregulation affects diverse aspects of development in Arabidopsis thaliana. Plant J. 2006;47:591-603 pubmed
    ..In this work Arabidopsis cullin 4 is shown to assemble with DDB1, RBX1, DET1 and DDB2 in vitro and in planta...
  6. Moon J, Zhao Y, Dai X, Zhang W, Gray W, Huq E, et al. A new CULLIN 1 mutant has altered responses to hormones and light in Arabidopsis. Plant Physiol. 2007;143:684-96 pubmed
    ..SCFs are composed of four subunits: CULLIN 1 (CUL1), ASK, RBX1, and an F-box protein...
  7. Hellmann H, Hobbie L, Chapman A, Dharmasiri S, Dharmasiri N, Del Pozo C, et al. Arabidopsis AXR6 encodes CUL1 implicating SCF E3 ligases in auxin regulation of embryogenesis. EMBO J. 2003;22:3314-25 pubmed
    ..In addition, we show that CUL1 has a role in auxin response throughout the life cycle of the plant. ..
  8. Gingerich D, Gagne J, Salter D, Hellmann H, Estelle M, Ma L, et al. Cullins 3a and 3b assemble with members of the broad complex/tramtrack/bric-a-brac (BTB) protein family to form essential ubiquitin-protein ligases (E3s) in Arabidopsis. J Biol Chem. 2005;280:18810-21 pubmed
    ..as scaffolds to form multisubunit E3 complexes in which the CUL binds a target recognition subcomplex and the RBX1 docking protein, which delivers the activated ubiquitin moiety...
  9. Chen H, Shen Y, Tang X, Yu L, Wang J, Guo L, et al. Arabidopsis CULLIN4 Forms an E3 Ubiquitin Ligase with RBX1 and the CDD Complex in Mediating Light Control of Development. Plant Cell. 2006;18:1991-2004 pubmed
    ..Thus, this study suggests a biochemical activity connection between CSN and CDD complexes in their cooperation with COP1 in orchestrating the repression of photomorphogenesis. ..

More Information

Publications15

  1. Xu L, Liu F, Lechner E, Genschik P, Crosby W, Ma H, et al. The SCF(COI1) ubiquitin-ligase complexes are required for jasmonate response in Arabidopsis. Plant Cell. 2002;14:1919-35 pubmed
    ..In this study, we demonstrate that COI1 associates physically with AtCUL1, AtRbx1, and either of the Arabidopsis Skp1-like proteins ASK1 or ASK2 to assemble ubiquitin-ligase complexes, which we ..
  2. Gray W, Hellmann H, Dharmasiri S, Estelle M. Role of the Arabidopsis RING-H2 protein RBX1 in RUB modification and SCF function. Plant Cell. 2002;14:2137-44 pubmed
    ..The RING-H2 finger protein RBX1 is a subunit of SCF complexes in fungi and animals...
  3. Weber H, Bernhardt A, Dieterle M, Hano P, Mutlu A, Estelle M, et al. Arabidopsis AtCUL3a and AtCUL3b form complexes with members of the BTB/POZ-MATH protein family. Plant Physiol. 2005;137:83-93 pubmed
    ..In addition, we show that AtCUL3 proteins assemble with the RING-finger protein AtRBX1 and are targets for the RUB-conjugation pathway...
  4. Lechner E, Xie D, Grava S, Pigaglio E, Planchais S, Murray J, et al. The AtRbx1 protein is part of plant SCF complexes, and its down-regulation causes severe growth and developmental defects. J Biol Chem. 2002;277:50069-80 pubmed
    ..investigate the function of SCF, we characterized at the molecular level the Arabidopsis RING-H2 finger protein AtRbx1. We demonstrated that the plant gene is able to functionally complement a yeast knockout mutant strain and showed ..
  5. Dharmasiri S, Dharmasiri N, Hellmann H, Estelle M. The RUB/Nedd8 conjugation pathway is required for early development in Arabidopsis. EMBO J. 2003;22:1762-70 pubmed
    ..In addition, we show that RCE1 interacts directly with the RING protein RBX1 and is present in a stable complex with SCF. We propose that RBX1 functions as an E3 for RUB modification of CUL1.
  6. Figueroa P, Gusmaroli G, Serino G, Habashi J, Ma L, Shen Y, et al. Arabidopsis has two redundant Cullin3 proteins that are essential for embryo development and that interact with RBX1 and BTB proteins to form multisubunit E3 ubiquitin ligase complexes in vivo. Plant Cell. 2005;17:1180-95 pubmed
    ..Besides supporting anticipated specific AtCUL3 interactions with the RING protein AtRBX1 and representative Arabidopsis proteins containing a BTB domain in vitro, we show that AtCUL3 cofractionates and ..