Gene Symbol: RAP2.12
Description: related to AP2 12
Alias: T18A20.14, T18A20_14, related to AP2 12, related to AP2 12
Species: thale cress

Top Publications

  1. Licausi F, Kosmacz M, Weits D, Giuntoli B, Giorgi F, Voesenek L, et al. Oxygen sensing in plants is mediated by an N-end rule pathway for protein destabilization. Nature. 2011;479:419-22 pubmed publisher
    ..Our discovery of an oxygen-sensing mechanism opens up new possibilities for improving flooding tolerance in crops. ..
  2. Paul M, Iyer S, Amerhauser C, Lehmann M, van Dongen J, Geigenberger P. Oxygen Sensing via the Ethylene Response Transcription Factor RAP2.12 Affects Plant Metabolism and Performance under Both Normoxia and Hypoxia. Plant Physiol. 2016;172:141-53 pubmed publisher
    ..These results show that oxygen-sensing, mediating RAP2.12 degradation is indispensable to optimize metabolic performance, plant growth, and development under both normoxic and hypoxic conditions. ..
  3. Eysholdt Derzsó E, Sauter M. Root Bending Is Antagonistically Affected by Hypoxia and ERF-Mediated Transcription via Auxin Signaling. Plant Physiol. 2017;175:412-423 pubmed publisher
    ..Taken together, we show that hypoxia triggers an escape response of the primary root that is controlled by ERFVII activity and mediated by auxin signaling in the root tip. ..
  4. Giuntoli B, Lee S, Licausi F, Kosmacz M, Oosumi T, van Dongen J, et al. A trihelix DNA binding protein counterbalances hypoxia-responsive transcriptional activation in Arabidopsis. PLoS Biol. 2014;12:e1001950 pubmed publisher
    ..12. This mechanism is crucial for plant survival under suboptimal oxygenation conditions. The discovery of the feedback loop regulating the oxygen-sensing mechanism in plants opens new perspectives for breeding flood-resistant crops. ..
  5. Papdi C, Pérez Salamó I, Joseph M, Giuntoli B, Bögre L, Koncz C, et al. The low oxygen, oxidative and osmotic stress responses synergistically act through the ethylene response factor VII genes RAP2.12, RAP2.2 and RAP2.3. Plant J. 2015;82:772-84 pubmed publisher
    ..12 and its homologues RAP2.2 and RAP2.3 act redundantly in multiple stress responses. Alternative protein degradation pathways may provide inputs to the RAP2 transcription factors for the distinct stresses. ..
  6. Gasch P, Fundinger M, Müller J, Lee T, Bailey Serres J, Mustroph A. Redundant ERF-VII Transcription Factors Bind to an Evolutionarily Conserved cis-Motif to Regulate Hypoxia-Responsive Gene Expression in Arabidopsis. Plant Cell. 2016;28:160-80 pubmed publisher
    ..This motif, designated the hypoxia-responsive promoter element, is enriched in promoters of hypoxia-responsive genes in multiple species. ..
  7. Okamuro J, Caster B, Villarroel R, Van Montagu M, Jofuku K. The AP2 domain of APETALA2 defines a large new family of DNA binding proteins in Arabidopsis. Proc Natl Acad Sci U S A. 1997;94:7076-81 pubmed
    ..Moreover, the expression of at least three RAP2 genes in vegetative tissues are controlled by AP2. Thus, unlike other floral homeotic genes, AP2 is active during both reproductive and vegetative development. ..
  8. Yao Y, He R, Xie Q, Zhao X, Deng X, He J, et al. ETHYLENE RESPONSE FACTOR 74 (ERF74) plays an essential role in controlling a respiratory burst oxidase homolog D (RbohD)-dependent mechanism in response to different stresses in Arabidopsis. New Phytol. 2017;213:1667-1681 pubmed publisher