Gene Symbol: PYR1
Description: Polyketide cyclase/dehydrase and lipid transport superfamily protein
Alias: PYRABACTIN RESISTANCE 1, RCAR11, T6K21.50, T6K21_50, regulatory component of ABA receptor 11, Polyketide cyclase/dehydrase and lipid transport superfamily protein
Species: thale cress

Top Publications

  1. Melcher K, Ng L, Zhou X, Soon F, Xu Y, Suino Powell K, et al. A gate-latch-lock mechanism for hormone signalling by abscisic acid receptors. Nature. 2009;462:602-8 pubmed publisher
    ..Together, our results identify a conserved gate-latch-lock mechanism underlying ABA signalling. ..
  2. Nishimura N, Hitomi K, Arvai A, Rambo R, Hitomi C, Cutler S, et al. Structural mechanism of abscisic acid binding and signaling by dimeric PYR1. Science. 2009;326:1373-9 pubmed publisher
    ..Here, we report structures of pyrabactin resistance 1 (PYR1), a prototypical PYR/PYR1-like (PYL)/regulatory component of ABA receptor (RCAR) protein that ..
  3. Dupeux F, Santiago J, Betz K, Twycross J, Park S, Rodriguez L, et al. A thermodynamic switch modulates abscisic acid receptor sensitivity. EMBO J. 2011;30:4171-84 pubmed publisher
    ..ABA binding to pyrabactin resistance (PYR)/PYR1-like (PYL)/Regulatory Component of Abscisic acid Receptor (RCAR) intracellular receptors promotes the formation of ..
  4. Park S, Fung P, Nishimura N, Jensen D, Fujii H, Zhao Y, et al. Abscisic acid inhibits type 2C protein phosphatases via the PYR/PYL family of START proteins. Science. 2009;324:1068-71 pubmed publisher
    ..Pyrabactin acts through PYRABACTIN RESISTANCE 1 (PYR1), the founding member of a family of START proteins called PYR/PYLs, which are necessary for both ..
  5. Santiago J, Dupeux F, Round A, Antoni R, Park S, Jamin M, et al. The abscisic acid receptor PYR1 in complex with abscisic acid. Nature. 2009;462:665-8 pubmed publisher
    ..Here we present the crystal structure of Arabidopsis thaliana PYR1, which consists of a dimer in which one of the subunits is bound to ABA...
  6. Dupeux F, Antoni R, Betz K, Santiago J, Gonzalez Guzman M, Rodriguez L, et al. Modulation of abscisic acid signaling in vivo by an engineered receptor-insensitive protein phosphatase type 2C allele. Plant Physiol. 2011;156:106-16 pubmed publisher
    ..ABA binding to PYRABACTIN RESISTANCE1 (PYR1)/PYR1-LIKE (PYL)/REGULATORY COMPONENTS OF ABA RECEPTORS intracellular receptors leads to inhibition of key negative ..
  7. Santiago J, Rodrigues A, Saez A, Rubio S, Antoni R, Dupeux F, et al. Modulation of drought resistance by the abscisic acid receptor PYL5 through inhibition of clade A PP2Cs. Plant J. 2009;60:575-88 pubmed publisher
    ..Moreover, we show that enhanced resistance to drought can be obtained through PYL5-mediated inhibition of clade A PP2Cs. ..
  8. Melcher K, Xu Y, Ng L, Zhou X, Soon F, Chinnusamy V, et al. Identification and mechanism of ABA receptor antagonism. Nat Struct Mol Biol. 2010;17:1102-8 pubmed publisher
    ..Here we demonstrate that pyrabactin is an agonist of PYR1 and PYL1 but is unexpectedly an antagonist of PYL2...
  9. Peterson F, Burgie E, Park S, Jensen D, Weiner J, Bingman C, et al. Structural basis for selective activation of ABA receptors. Nat Struct Mol Biol. 2010;17:1109-13 pubmed publisher
    ..We recently discovered a selective ABA agonist, pyrabactin, and used it to discover its primary target PYR1, the founding member of the PYR/PYL family of soluble ABA receptors...

More Information


  1. Nishimura N, Sarkeshik A, Nito K, Park S, Wang A, Carvalho P, et al. PYR/PYL/RCAR family members are major in-vivo ABI1 protein phosphatase 2C-interacting proteins in Arabidopsis. Plant J. 2010;61:290-9 pubmed publisher
    ..ABI1-PYR1 interaction was stimulated within 5 min of ABA treatment in Arabidopsis. Interestingly, in contrast, PYR1 and SnRK2...
  2. Kim W, Lee Y, Park J, Lee N, Choi G. HONSU, a protein phosphatase 2C, regulates seed dormancy by inhibiting ABA signaling in Arabidopsis. Plant Cell Physiol. 2013;54:555-72 pubmed publisher
    ..Like other PP2C family members, HON interacts with PYR1/RCAR11 in the presence of ABA...
  3. Rodriguez L, Gonzalez Guzman M, Díaz M, Rodrigues A, Izquierdo Garcia A, Peirats Llobet M, et al. C2-domain abscisic acid-related proteins mediate the interaction of PYR/PYL/RCAR abscisic acid receptors with the plasma membrane and regulate abscisic acid sensitivity in Arabidopsis. Plant Cell. 2014;26:4802-20 pubmed publisher
    ..In summary, we identified PYR/PYL-interacting partners that mediate a transient Ca(2+)-dependent interaction with phospholipid vesicles, which affects PYR/PYL subcellular localization and positively regulates ABA signaling. ..
  4. Bueso E, Rodriguez L, Lorenzo Orts L, Gonzalez Guzman M, Sayas E, Muñoz Bertomeu J, et al. The single-subunit RING-type E3 ubiquitin ligase RSL1 targets PYL4 and PYR1 ABA receptors in plasma membrane to modulate abscisic acid signaling. Plant J. 2014;80:1057-71 pubmed publisher
    ..In this study we describe a single-subunit RING-type E3 ubiquitin ligase RSL1 that interacts with the PYL4 and PYR1 ABA receptors at the plasma membrane...
  5. Park E, Kim T. Production of ABA responses requires both the nuclear and cytoplasmic functional involvement of PYR1. Biochem Biophys Res Commun. 2017;484:34-39 pubmed publisher
    ..Because PYR1 is known to localize to nucleus and cytoplasm it is a question whether nuclear or cytoplasmic PYR1 confer different ..
  6. Merilo E, Laanemets K, Hu H, Xue S, Jakobson L, Tulva I, et al. PYR/RCAR receptors contribute to ozone-, reduced air humidity-, darkness-, and CO2-induced stomatal regulation. Plant Physiol. 2013;162:1652-68 pubmed publisher
    ..Thus, we show that PYR/RCAR receptors play an important role for the whole-plant stomatal adjustments and responses to low humidity, darkness, and O3 and are involved in responses to elevated CO2. ..
  7. Zhang X, Jiang L, Wang G, Yu L, Zhang Q, Xin Q, et al. Structural insights into the abscisic acid stereospecificity by the ABA receptors PYR/PYL/RCAR. PLoS ONE. 2013;8:e67477 pubmed publisher
    ..Our results provide novel insights of the bioactivity of ABA enantiomers onto PYLs, and shed light on designing the selective ABA receptors agonists. ..
  8. Bhaskara G, Nguyen T, Verslues P. Unique drought resistance functions of the highly ABA-induced clade A protein phosphatase 2Cs. Plant Physiol. 2012;160:379-95 pubmed publisher
    ..Both this and their distinct PYL interaction demonstrate a new level of functional differentiation among the clade A PP2Cs and a point of cross talk between ABA-dependent and ABA-independent drought-associated signaling. ..
  9. Park S, Peterson F, Mosquna A, Yao J, Volkman B, Cutler S. Agrochemical control of plant water use using engineered abscisic acid receptors. Nature. 2015;520:545-8 pubmed publisher
    ..Here we describe a variant of the ABA receptor PYRABACTIN RESISTANCE 1 (PYR1) that possesses nanomolar sensitivity to the agrochemical mandipropamid and demonstrate its ..
  10. Dorosh L, Kharenko O, Rajagopalan N, Loewen M, Stepanova M. Molecular mechanisms in the activation of abscisic acid receptor PYR1. PLoS Comput Biol. 2013;9:e1003114 pubmed publisher
    The pyrabactin resistance 1 (PYR1)/PYR1-like (PYL)/regulatory component of abscisic acid (ABA) response (RCAR) proteins comprise a well characterized family of ABA receptors...
  11. Zhao Y, Chan Z, Xing L, Liu X, Hou Y, Chinnusamy V, et al. The unique mode of action of a divergent member of the ABA-receptor protein family in ABA and stress signaling. Cell Res. 2013;23:1380-95 pubmed publisher
    ..Our results show that PYL13 is not an ABA receptor but can modulate the ABA pathway by interacting with and inhibiting both the PYL receptors and the PP2C co-receptors...
  12. Shibata N, Kagiyama M, Nakagawa M, Hirano Y, Hakoshima T. Crystallization of the plant hormone receptors PYL9/RCAR1, PYL5/RCAR8 and PYR1/RCAR11 in the presence of (+)-abscisic acid. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2010;66:456-9 pubmed publisher
    ..for a member of each of the subfamilies, PYL9/RCAR1 from subfamily I, PYL5/RCAR8 from subfamily II and PYR1/RCAR11 from subfamily III, in the presence of (+)-abscisic acid...
  13. Ye Y, Zhou L, Liu X, Liu H, Li D, Cao M, et al. A Novel Chemical Inhibitor of ABA Signaling Targets All ABA Receptors. Plant Physiol. 2017;173:2356-2369 pubmed publisher group A type 2C protein phosphatases (PP2Cs), and then ABA binds to its receptor of the ACTIN RESISTANCE1 (PYR1), PYR1-LIKE (PYL), and REGULATORY COMPONENTS OF ABA RECEPTORS (RCAR) family, which, in turn, inhibits PP2Cs and ..