Gene Symbol: PYL2
Description: PYR1-like 2
Alias: PYR1-like 2, RCAR14, T19L18.15, T19L18_15, regulatory components of ABA receptor 14, PYR1-like 2
Species: thale cress

Top Publications

  1. Park S, Fung P, Nishimura N, Jensen D, Fujii H, Zhao Y, et al. Abscisic acid inhibits type 2C protein phosphatases via the PYR/PYL family of START proteins. Science. 2009;324:1068-71 pubmed publisher
    ..Our results illustrate the power of the chemical genetic approach for sidestepping genetic redundancy. ..
  2. Melcher K, Ng L, Zhou X, Soon F, Xu Y, Suino Powell K, et al. A gate-latch-lock mechanism for hormone signalling by abscisic acid receptors. Nature. 2009;462:602-8 pubmed publisher
    ..Here we report crystal structures of apo and ABA-bound receptors as well as a ternary PYL2-ABA-PP2C complex...
  3. Zhang X, Zhang Q, Xin Q, Yu L, Wang Z, Wu W, et al. Complex structures of the abscisic acid receptor PYL3/RCAR13 reveal a unique regulatory mechanism. Structure. 2012;20:780-90 pubmed publisher
    ..According to different conformations of ligand-bound PYLs, the PYLs family can be divided into three subclasses, among which the trans-dimeric subclass, represented by PYL3, reveals a distinct regulatory mechanism. ..
  4. Bhaskara G, Nguyen T, Verslues P. Unique drought resistance functions of the highly ABA-induced clade A protein phosphatase 2Cs. Plant Physiol. 2012;160:379-95 pubmed publisher
    ..Both this and their distinct PYL interaction demonstrate a new level of functional differentiation among the clade A PP2Cs and a point of cross talk between ABA-dependent and ABA-independent drought-associated signaling. ..
  5. Nishimura N, Sarkeshik A, Nito K, Park S, Wang A, Carvalho P, et al. PYR/PYL/RCAR family members are major in-vivo ABI1 protein phosphatase 2C-interacting proteins in Arabidopsis. Plant J. 2010;61:290-9 pubmed publisher
    ..To investigate the biological relevance of the PYR/PYLs, we analysed pyr1/pyl1/pyl2/pyl4 quadruple mutant plants and found strong insensitivities in ABA-induced stomatal closure and ABA-inhibition of ..
  6. Soon F, Ng L, Zhou X, West G, Kovach A, Tan M, et al. Molecular mimicry regulates ABA signaling by SnRK2 kinases and PP2C phosphatases. Science. 2012;335:85-8 pubmed publisher
    ..These structural results provide a simple mechanism that directly couples ABA binding to SnRK2 kinase activation and highlight a new paradigm of kinase-phosphatase regulation through mutual packing of their catalytic sites. ..
  7. Zhang X, Jiang L, Wang G, Yu L, Zhang Q, Xin Q, et al. Structural insights into the abscisic acid stereospecificity by the ABA receptors PYR/PYL/RCAR. PLoS ONE. 2013;8:e67477 pubmed publisher
    ..Our results provide novel insights of the bioactivity of ABA enantiomers onto PYLs, and shed light on designing the selective ABA receptors agonists. ..
  8. Minkoff B, Stecker K, Sussman M. Rapid Phosphoproteomic Effects of Abscisic Acid (ABA) on Wild-Type and ABA Receptor-Deficient A. thaliana Mutants. Mol Cell Proteomics. 2015;14:1169-82 pubmed publisher
    ..Altogether, these data expand our understanding of the model by which the family of ABA receptors directs rapid phosphoproteomic changes. ..
  9. Melcher K, Xu Y, Ng L, Zhou X, Soon F, Chinnusamy V, et al. Identification and mechanism of ABA receptor antagonism. Nat Struct Mol Biol. 2010;17:1102-8 pubmed publisher
    ..Here we demonstrate that pyrabactin is an agonist of PYR1 and PYL1 but is unexpectedly an antagonist of PYL2. Crystal structures of the PYL2-pyrabactin and PYL1-pyrabactin-ABI1 complexes reveal the mechanism responsible for ..

More Information


  1. West G, Pascal B, Ng L, Soon F, Melcher K, Xu H, et al. Protein conformation ensembles monitored by HDX reveal a structural rationale for abscisic acid signaling protein affinities and activities. Structure. 2013;21:229-35 pubmed publisher
    ..Here, insights into the structural mechanism of proteins in the ABA signaling pathway (the ABA receptor PYL2, HAB1 phosphatase, and two kinases, SnRK2.3 and 2...
  2. Peterson F, Burgie E, Park S, Jensen D, Weiner J, Bingman C, et al. Structural basis for selective activation of ABA receptors. Nat Struct Mol Biol. 2010;17:1109-13 pubmed publisher
    ..Our results provide a robust framework for the design of new agonists and reveal a new mechanism for agonist selectivity. ..
  3. Zhao Y, Chan Z, Xing L, Liu X, Hou Y, Chinnusamy V, et al. The unique mode of action of a divergent member of the ABA-receptor protein family in ABA and stress signaling. Cell Res. 2013;23:1380-95 pubmed publisher
    ..Our results show that PYL13 is not an ABA receptor but can modulate the ABA pathway by interacting with and inhibiting both the PYL receptors and the PP2C co-receptors...