Gene Symbol: PSKR1
Description: phytosulfokin receptor 1
Alias: ATPSKR1, PHYTOSULFOKIN RECEPTOR, PHYTOSULFOKIN RECEPTOR 1, PSK RECEPTOR 1, phytosulfokin receptor 1, phytosulfokin receptor 1
Species: thale cress

Top Publications

  1. Amano Y, Tsubouchi H, Shinohara H, Ogawa M, Matsubayashi Y. Tyrosine-sulfated glycopeptide involved in cellular proliferation and expansion in Arabidopsis. Proc Natl Acad Sci U S A. 2007;104:18333-8 pubmed
    ..The present results suggest that this paralogous LRR-RK family integrates growth-promoting signals mediated by two structurally distinct sulfated peptides: PSY1 and PSK. ..
  2. Matsubayashi Y, Ogawa M, Kihara H, Niwa M, Sakagami Y. Disruption and overexpression of Arabidopsis phytosulfokine receptor gene affects cellular longevity and potential for growth. Plant Physiol. 2006;142:45-53 pubmed
    ..that loss-of-function and gain-of-function mutations of the Arabidopsis (Arabidopsis thaliana) PSK receptor gene (AtPSKR1) alter cellular longevity and potential for growth without interfering with basic morphogenesis of plants...
  3. Mosher S, Seybold H, Rodriguez P, Stahl M, Davies K, Dayaratne S, et al. The tyrosine-sulfated peptide receptors PSKR1 and PSY1R modify the immunity of Arabidopsis to biotrophic and necrotrophic pathogens in an antagonistic manner. Plant J. 2013;73:469-82 pubmed publisher
    ..In a reverse genetic screen, we identified the phytosulfokine (PSK) receptor PSKR1 as an important component of plant defense...
  4. Stührwohldt N, Dahlke R, Steffens B, Johnson A, Sauter M. Phytosulfokine-α controls hypocotyl length and cell expansion in Arabidopsis thaliana through phytosulfokine receptor 1. PLoS ONE. 2011;6:e21054 pubmed publisher
    ..In this study, a role for PSK signaling through PSK receptor PSKR1 in Arabidopsis thaliana hypocotyl cell elongation is established...
  5. Kutschmar A, Rzewuski G, Stührwohldt N, Beemster G, Inze D, Sauter M. PSK-? promotes root growth in Arabidopsis. New Phytol. 2009;181:820-31 pubmed publisher
    ..In this study, the involvement of PSK signaling through the PSK receptor gene AtPSKR1 in Arabidopsis root growth was assessed...
  6. Hartmann J, Stührwohldt N, Dahlke R, Sauter M. Phytosulfokine control of growth occurs in the epidermis, is likely to be non-cell autonomous and is dependent on brassinosteroids. Plant J. 2013;73:579-90 pubmed publisher
    ..Expression of PSKR1 under the control of tissue- and cell type-specific promoters in a receptor null background strongly suggests that ..
  7. Kwezi L, Ruzvidzo O, Wheeler J, Govender K, Iacuone S, Thompson P, et al. The phytosulfokine (PSK) receptor is capable of guanylate cyclase activity and enabling cyclic GMP-dependent signaling in plants. J Biol Chem. 2011;286:22580-8 pubmed publisher
    ..We expressed the recombinant complete kinase (cytoplasmic) domain of AtPSKR1 and show that it has serine/threonine kinase activity using the Ser/Thr peptide 1 as a substrate with an ..
  8. Igarashi D, Tsuda K, Katagiri F. The peptide growth factor, phytosulfokine, attenuates pattern-triggered immunity. Plant J. 2012;71:194-204 pubmed publisher
    ..This research was motivated by the observation that expression of the PSK Receptor 1 (PSKR1) gene was induced by MAMP treatment...
  9. Loivamäki M, Stührwohldt N, Deeken R, Steffens B, Roitsch T, Hedrich R, et al. A role for PSK signaling in wounding and microbial interactions in Arabidopsis. Physiol Plant. 2010;139:348-57 pubmed publisher
    ..Heynh and is perceived by leucine-rich repeat receptor kinases. Arabidopsis has two PSK receptor genes, PSKR1 and PSKR2...

More Information


  1. Mosher S, Kemmerling B. PSKR1 and PSY1R-mediated regulation of plant defense responses. Plant Signal Behav. 2013;8:e24119 pubmed publisher
    ..Our recent findings show that the tyrosine sulfated peptide receptors PSKR1 and PSY1R are not only involved in growth and development but also in plant defense...
  2. Hartmann J, Fischer C, Dietrich P, Sauter M. Kinase activity and calmodulin binding are essential for growth signaling by the phytosulfokine receptor PSKR1. Plant J. 2014;78:192-202 pubmed publisher
    ..To elucidate PSK receptor function we analyzed PSKR1 kinase activity and binding to Ca(2+) sensors and evaluated the contribution of these activities to growth control ..
  3. Wang J, Li H, Han Z, Zhang H, Wang T, Lin G, et al. Allosteric receptor activation by the plant peptide hormone phytosulfokine. Nature. 2015;525:265-8 pubmed publisher
    ..Our data reveal the structural basis for PSKR recognition of PSK and allosteric activation of PSKR by PSK, opening up new avenues for the design of PSKR-specific small molecules. ..
  4. Muleya V, Wheeler J, Ruzvidzo O, Freihat L, Manallack D, Gehring C, et al. Calcium is the switch in the moonlighting dual function of the ligand-activated receptor kinase phytosulfokine receptor 1. Cell Commun Signal. 2014;12:60 pubmed publisher
    ..A prototypical example is the phytosulfokine receptor 1 (PSKR1) that is involved in regulating growth responses in plants...
  5. Ladwig F, Dahlke R, Stührwohldt N, Hartmann J, Harter K, Sauter M. Phytosulfokine Regulates Growth in Arabidopsis through a Response Module at the Plasma Membrane That Includes CYCLIC NUCLEOTIDE-GATED CHANNEL17, H+-ATPase, and BAK1. Plant Cell. 2015;27:1718-29 pubmed publisher
    Phytosulfokine (PSK) is perceived by the leucine-rich repeat receptor kinase PSKR1 and promotes growth in Arabidopsis thaliana. PSKR1 is coexpressed with the CYCLIC NUCLEOTIDE-GATED CHANNEL gene CNGC17...
  6. Rodiuc N, Barlet X, Hok S, Perfus Barbeoch L, Allasia V, Engler G, et al. Evolutionarily distant pathogens require the Arabidopsis phytosulfokine signalling pathway to establish disease. Plant Cell Environ. 2016;39:1396-407 pubmed publisher
    ..characterized by the tissue-specific transcriptional regulation of genes encoding Arabidopsis PSKs and the PSK receptor 1 (PSKR1)...
  7. Hartmann J, Linke D, Bönniger C, Tholey A, Sauter M. Conserved phosphorylation sites in the activation loop of the Arabidopsis phytosulfokine receptor PSKR1 differentially affect kinase and receptor activity. Biochem J. 2015;472:379-91 pubmed publisher
    ..Phosphosite mapping of epitope-tagged PSKR1 (phytosulfokine receptor 1) from Arabidopsis thaliana plants identified Ser(696) and Ser(698) in the JM (..
  8. Muleya V, Marondedze C, Wheeler J, Thomas L, Mok Y, Griffin M, et al. Phosphorylation of the dimeric cytoplasmic domain of the phytosulfokine receptor, PSKR1. Biochem J. 2016;473:3081-98 pubmed publisher
    ..signal through a plasma membrane localized leucine-rich repeat receptor-like kinase (phytosulfokine receptor 1, PSKR1) that also contains a functional cytosolic guanylate cyclase with its cyclase catalytic center embedded within the ..