Gene Symbol: PRL1
Description: pleiotropic regulatory locus 1
Alias: DL3990W, FCAALL.40, PRL1 PROTEIN, pleiotropic regulatory locus 1, pleiotropic regulatory locus 1
Species: thale cress

Top Publications

  1. Palma K, Zhao Q, Cheng Y, Bi D, Monaghan J, Cheng W, et al. Regulation of plant innate immunity by three proteins in a complex conserved across the plant and animal kingdoms. Genes Dev. 2007;21:1484-93 pubmed
    ..protein complex containing at least three members--MOS4 (Modifier Of snc1, 4), AtCDC5, and PRL1 (Pleiotropic Regulatory Locus 1)--that are all essential for plant innate immunity...
  2. Baruah A, Simková K, Hincha D, Apel K, Laloi C. Modulation of O-mediated retrograde signaling by the PLEIOTROPIC RESPONSE LOCUS 1 (PRL1) protein, a central integrator of stress and energy signaling. Plant J. 2009;60:22-32 pubmed publisher map-based cloning and sequencing to contain a single amino acid change in the PLEIOTROPIC RESPONSE LOCUS 1 (PRL1) protein. PRL1 suppresses the expression of AAA-ATPase and other (1)O(2)-responsive genes...
  3. Nemeth K, Salchert K, Putnoky P, Bhalerao R, Koncz Kalman Z, Stankovic Stangeland B, et al. Pleiotropic control of glucose and hormone responses by PRL1, a nuclear WD protein, in Arabidopsis. Genes Dev. 1998;12:3059-73 pubmed
    The prl1 mutation localized by T-DNA tagging on Arabidopsis chromosome 4-44 confers hypersensitivity to glucose and sucrose...
  4. Bhalerao R, Salchert K, Bako L, Okrész L, Szabados L, Muranaka T, et al. Regulatory interaction of PRL1 WD protein with Arabidopsis SNF1-like protein kinases. Proc Natl Acad Sci U S A. 1999;96:5322-7 pubmed
    ..AKIN11, which can complement the Deltasnf1 mutation, were found to interact with an N-terminal domain of the PRL1 protein in the two-hybrid system and in vitro...
  5. Weihmann T, Palma K, Nitta Y, Li X. Pleiotropic regulatory locus 2 exhibits unequal genetic redundancy with its homolog PRL1. Plant Cell Physiol. 2012;53:1617-26 pubmed publisher
    ..b>PLEIOTROPIC REGULATORY LOCUS 1 (PRL1) and >20 other proteins are members of the MOS4-associated complex (MAC), a regulatory node ..
  6. Zhang S, Liu Y, Yu B. PRL1, an RNA-binding protein, positively regulates the accumulation of miRNAs and siRNAs in Arabidopsis. PLoS Genet. 2014;10:e1004841 pubmed publisher
    The evolutionary conserved WD-40 protein PRL1 plays important roles in immunity and development. Here we show that PRL1 is required for the accumulation of microRNAs (miRNAs) and small interfering RNAs (siRNAs)...
  7. Deng X, Lu T, Wang L, Gu L, Sun J, Kong X, et al. Recruitment of the NineTeen Complex to the activated spliceosome requires AtPRMT5. Proc Natl Acad Sci U S A. 2016;113:5447-52 pubmed publisher
  8. Flores Pérez U, Perez Gil J, Closa M, Wright L, Botella Pavía P, Phillips M, et al. Pleiotropic regulatory locus 1 (PRL1) integrates the regulation of sugar responses with isoprenoid metabolism in Arabidopsis. Mol Plant. 2010;3:101-12 pubmed publisher
    ..This mutant was found to be a new loss-of-function allele of PRL1 (Pleiotropic Regulatory Locus 1), a gene encoding a conserved WD-protein that functions as a global regulator of sugar, stress, and ..