Gene Symbol: PLDALPHA1
Description: phospholipase D alpha 1
Alias: PHOSPHOLIPASE D, PLD, phospholipase D alpha 1, phospholipase D alpha 1
Species: thale cress
Products:     PLDALPHA1

Top Publications

  1. Zhao J, Wang X. Arabidopsis phospholipase Dalpha1 interacts with the heterotrimeric G-protein alpha-subunit through a motif analogous to the DRY motif in G-protein-coupled receptors. J Biol Chem. 2004;279:1794-800 pubmed
    b>Phospholipase D (PLD) and heterotrimeric G-protein both play important, diverse roles in cellular regulation and signal transduction...
  2. Zhang Y, Zhu H, Zhang Q, Li M, Yan M, Wang R, et al. Phospholipase dalpha1 and phosphatidic acid regulate NADPH oxidase activity and production of reactive oxygen species in ABA-mediated stomatal closure in Arabidopsis. Plant Cell. 2009;21:2357-77 pubmed publisher
    We determined the role of Phospholipase Dalpha1 (PLDalpha1) and its lipid product phosphatidic acid (PA) in abscisic acid (ABA)-induced production of reactive oxygen species (ROS) in Arabidopsis thaliana guard cells...
  3. Bargmann B, Laxalt A, ter Riet B, Testerink C, Merquiol E, Mosblech A, et al. Reassessing the role of phospholipase D in the Arabidopsis wounding response. Plant Cell Environ. 2009;32:837-50 pubmed publisher
    ..b>Phospholipase D (PLD) has previously been implicated in the wounding response...
  4. Mishra G, Zhang W, Deng F, Zhao J, Wang X. A bifurcating pathway directs abscisic acid effects on stomatal closure and opening in Arabidopsis. Science. 2006;312:264-6 pubmed
    ..Here, we show that phospholipase Dalpha1 (PLDalpha1) mediates the ABA effects on stomata through interaction with a protein phosphatase 2C (PP2C) and a ..
  5. Sang Y, Cui D, Wang X. Phospholipase D and phosphatidic acid-mediated generation of superoxide in Arabidopsis. Plant Physiol. 2001;126:1449-58 pubmed
    b>Phospholipase D (PLD), which hydrolyzes phospholipids into free head groups and phosphatidic acid (PA), may regulate cellular processes through the production of lipid and lipid-derived messengers...
  6. Jiang Y, Wu K, Lin F, Qu Y, Liu X, Zhang Q. Phosphatidic acid integrates calcium signaling and microtubule dynamics into regulating ABA-induced stomatal closure in Arabidopsis. Planta. 2014;239:565-75 pubmed publisher
    ..In this study, the regulation and dynamic organization of microtubules during ABA-induced stomatal closure by phospholipase D (PLD) and its product PA were investigated...
  7. Zien C, Wang C, Wang X, Welti R. In vivo substrates and the contribution of the common phospholipase D, PLDalpha, to wound-induced metabolism of lipids in Arabidopsis. Biochim Biophys Acta. 2001;1530:236-48 pubmed
    The common plant phospholipase D (PLD), PLDalpha, has been proposed to be involved in wound-induced production of jasmonic acid...
  8. Zhang Q, Lin F, Mao T, Nie J, Yan M, Yuan M, et al. Phosphatidic acid regulates microtubule organization by interacting with MAP65-1 in response to salt stress in Arabidopsis. Plant Cell. 2012;24:4555-76 pubmed publisher
    ..Here, we report that phosphatidic acid (PA), a product of phospholipase D (PLD), regulates MAP65-1, a microtubule-associated protein, in response to salt stress...
  9. Roy Choudhury S, Pandey S. The role of PLD?1 in providing specificity to signal-response coupling by heterotrimeric G-protein components in Arabidopsis. Plant J. 2016;86:50-61 pubmed publisher
    ..We now present evidence that the phospholipase D?1 protein is a key component and modulator of the G-protein complex in affecting a subset of signaling ..

More Information


  1. Qu Y, An Z, Zhuang B, Jing W, Zhang Q, Zhang W. Copper amine oxidase and phospholipase D act independently in abscisic acid (ABA)-induced stomatal closure in Vicia faba and Arabidopsis. J Plant Res. 2014;127:533-44 pubmed publisher
    Recent evidence has demonstrated that both copper amine oxidase (CuAO; EC and phospholipase D (PLD; EC are involved in abscisic acid (ABA)-induced stomatal closure...
  2. Zhang Q, Qu Y, Wang Q, Song P, Wang P, Jia Q, et al. Arabidopsis phospholipase D alpha 1-derived phosphatidic acid regulates microtubule organization and cell development under microtubule-interacting drugs treatment. J Plant Res. 2017;130:193-202 pubmed publisher
    b>Phospholipase D (PLD) and its product phosphatidic acid (PA) are emerging as essential regulators of cytoskeleton organization in plants...
  3. Gookin T, Assmann S. Significant reduction of BiFC non-specific assembly facilitates in planta assessment of heterotrimeric G-protein interactors. Plant J. 2014;80:553-67 pubmed publisher
    ..We further demonstrate that GPA1 and AGB1 each physically interact with PLDα1 in planta, and that mutation of the so-called PLDα1 'DRY' motif abolishes both of these interactions.
  4. Devaiah S, Pan X, Hong Y, Roth M, Welti R, Wang X. Enhancing seed quality and viability by suppressing phospholipase D in Arabidopsis. Plant J. 2007;50:950-7 pubmed
    ..Ablation of the gene for a membrane lipid-hydrolyzing phospholipase D (PLDalpha1) in Arabidopsis enhanced seed germination and oil stability after storage or exposure of seeds to ..
  5. Fan L, Zheng S, Cui D, Wang X. Subcellular distribution and tissue expression of phospholipase Dalpha, Dbeta, and Dgamma in Arabidopsis. Plant Physiol. 1999;119:1371-8 pubmed flowers, siliques, and roots than in dry seeds and mature leaves, whereas the polyphosphoinositide-dependent PLD activity was greater in older, senescing leaves than in other organs...
  6. Camehl I, Drzewiecki C, Vadassery J, Shahollari B, Sherameti I, Forzani C, et al. The OXI1 kinase pathway mediates Piriformospora indica-induced growth promotion in Arabidopsis. PLoS Pathog. 2011;7:e1002051 pubmed publisher
    ..Under beneficial co-cultivation conditions, H?O? formation is even reduced by the fungus. Importantly, phospholipase D (PLD)?1 or PLD? mutants, which are impaired in PA synthesis do not show growth promotion in response to ..
  7. Qin W, Pappan K, Wang X. Molecular heterogeneity of phospholipase D (PLD). Cloning of PLDgamma and regulation of plant PLDgamma, -beta, and -alpha by polyphosphoinositides and calcium. J Biol Chem. 1997;272:28267-73 pubmed
    b>Phospholipase D (PLD) has emerged as an important enzyme involved in signal transduction, vesicle trafficking, and membrane metabolism...
  8. Xiao S, Gao W, Chen Q, Chan S, Zheng S, Ma J, et al. Overexpression of Arabidopsis acyl-CoA binding protein ACBP3 promotes starvation-induced and age-dependent leaf senescence. Plant Cell. 2010;22:1463-82 pubmed publisher
    ..Accelerated senescence in ACBP3-OEs is dependent on salicylic acid but not jasmonic acid signaling. ..
  9. Du Z, Chen M, Chen Q, Xiao S, Chye M. Arabidopsis acyl-CoA-binding protein ACBP1 participates in the regulation of seed germination and seedling development. Plant J. 2013;74:294-309 pubmed publisher
    ..RNA assays showed that ACBP1 over-production in 12-day-old seedlings up-regulated the expression of PHOSPHOLIPASE D?1 (PLD?1) and three ABA/stress-responsive genes: ABA-RESPONSIVE ELEMENT BINDING PROTEIN1 (AREB1), RESPONSE TO ..
  10. Uraji M, Katagiri T, Okuma E, Ye W, Hossain M, Masuda C, et al. Cooperative function of PLD? and PLD?1 in abscisic acid-induced stomatal closure in Arabidopsis. Plant Physiol. 2012;159:450-60 pubmed publisher
    b>Phospholipase D (PLD) is involved in responses to abiotic stress and abscisic acid (ABA) signaling...
  11. Rajashekar C, Zhou H, Zhang Y, Li W, Wang X. Suppression of phospholipase Dalpha1 induces freezing tolerance in Arabidopsis: response of cold-responsive genes and osmolyte accumulation. J Plant Physiol. 2006;163:916-26 pubmed
    b>Phospholipase D (PLD; EC plays an important role in membrane lipid hydrolysis and in mediation of plant responses to a wide range of stresses...
  12. Guo L, Mishra G, Markham J, Li M, Tawfall A, Welti R, et al. Connections between sphingosine kinase and phospholipase D in the abscisic acid signaling pathway in Arabidopsis. J Biol Chem. 2012;287:8286-96 pubmed publisher
    ..we isolated Arabidopsis thaliana SPHK mutants sphk1-1 and sphk2-1 and characterized them, together with phospholipase D?1 knock-out, pld?1, in plant response to ABA...
  13. Li W, Wang R, Li M, Li L, Wang C, Welti R, et al. Differential degradation of extraplastidic and plastidic lipids during freezing and post-freezing recovery in Arabidopsis thaliana. J Biol Chem. 2008;283:461-8 pubmed
    ..We previously showed that phospholipase D (PLD) is involved in lipid hydrolysis and Arabidopsis thaliana freezing tolerance...
  14. Mane S, Vasquez Robinet C, Sioson A, Heath L, Grene R. Early PLDalpha-mediated events in response to progressive drought stress in Arabidopsis: a transcriptome analysis. J Exp Bot. 2007;58:241-52 pubmed
    b>Phospholipase D (PLD) has been implicated in a variety of stresses including osmotic stress and wounding. PLDalpha1-derived phosphatidic acid interacts with ABI1 phosphatase 2C and promotes abscisic acid signalling...