PHYA

Summary

Gene Symbol: PHYA
Description: phytochrome A
Alias: ELONGATED HYPOCOTYL 8, F14J9.23, F14J9_23, FAR RED ELONGATED 1, FAR RED ELONGATED HYPOCOTYL 2, FHY2, FRE1, HY8, phytochrome A, phytochrome A
Species: thale cress

Top Publications

  1. Franklin K, Allen T, Whitelam G. Phytochrome A is an irradiance-dependent red light sensor. Plant J. 2007;50:108-17 pubmed
    ..In Arabidopsis thaliana, five phytochromes (phyA-phyE) have been identified and characterized...
  2. Tepperman J, Hwang Y, Quail P. phyA dominates in transduction of red-light signals to rapidly responding genes at the initiation of Arabidopsis seedling de-etiolation. Plant J. 2006;48:728-42 pubmed
    ..profiles of genes responding to Rc within 1 h (early response genes) of initial exposure of dark-grown wild-type, phyA, phyB and phyAphyB double mutant seedlings to the light signal...
  3. Al Sady B, Ni W, Kircher S, Schafer E, Quail P. Photoactivated phytochrome induces rapid PIF3 phosphorylation prior to proteasome-mediated degradation. Mol Cell. 2006;23:439-46 pubmed
    Following light-induced nuclear translocation, specific members of the phytochrome (phy) photoreceptor family (phyA to phyE) interact with bHLH transcription factors, such as PIF3, and induce changes in target-gene expression...
  4. Müller R, Fernández A, Hiltbrunner A, Schafer E, Kretsch T. The histidine kinase-related domain of Arabidopsis phytochrome a controls the spectral sensitivity and the subcellular distribution of the photoreceptor. Plant Physiol. 2009;150:1297-309 pubmed publisher
    b>Phytochrome A (phyA) is the primary photoreceptor for sensing extremely low amounts of light and for mediating various far-red light-induced responses in higher plants...
  5. Rausenberger J, Tscheuschler A, Nordmeier W, Wüst F, Timmer J, Schafer E, et al. Photoconversion and nuclear trafficking cycles determine phytochrome A's response profile to far-red light. Cell. 2011;146:813-25 pubmed publisher
    b>Phytochrome A (phyA) is the only photoreceptor in plants, initiating responses in far-red light and, as such, essential for survival in canopy shade...
  6. Su Y, Lagarias J. Light-independent phytochrome signaling mediated by dominant GAF domain tyrosine mutants of Arabidopsis phytochromes in transgenic plants. Plant Cell. 2007;19:2124-39 pubmed
    ..photoinsensitive Tyr-to-His mutant alleles of Arabidopsis thaliana phytochrome B (PHYB(Y276H)) and Arabidopsis phytochrome A (PHYA(Y242H)) in transgenic Arabidopsis plants, we demonstrate that photoconversion is not a prerequisite for ..
  7. Qin Y, Guo M, Li X, Xiong X, He C, Nie X, et al. Stress responsive gene CIPK14 is involved in phytochrome A-mediated far-red light inhibition of greening in Arabidopsis. Sci China Life Sci. 2010;53:1307-14 pubmed publisher
    In this study, we show that CIPK14, a stress responsive CBL-interacting protein kinase gene, is involved in phytochrome A-mediated far-red light inhibition of greening in Arabidopsis seedlings...
  8. Huq E, Al Sady B, Hudson M, Kim C, Apel K, Quail P. Phytochrome-interacting factor 1 is a critical bHLH regulator of chlorophyll biosynthesis. Science. 2004;305:1937-41 pubmed
  9. Hiltbrunner A, Viczian A, Bury E, Tscheuschler A, Kircher S, Toth R, et al. Nuclear accumulation of the phytochrome A photoreceptor requires FHY1. Curr Biol. 2005;15:2125-30 pubmed
    ..Arabidopsis has five phytochromes, phyA-phyE, among which phyA and phyB play the most predominant functions ...

More Information

Publications84

  1. Ni M, Tepperman J, Quail P. PIF3, a phytochrome-interacting factor necessary for normal photoinduced signal transduction, is a novel basic helix-loop-helix protein. Cell. 1998;95:657-67 pubmed
    ..PIF3 binds to wild-type C-terminal domains of both phyA and phyB, but less strongly to signaling-defective, missense mutant-containing domains...
  2. Warnasooriya S, Porter K, Montgomery B. Tissue- and isoform-specific phytochrome regulation of light-dependent anthocyanin accumulation in Arabidopsis thaliana. Plant Signal Behav. 2011;6:624-31 pubmed
    ..Mesophyll-specific phyA alone has been linked to the regulation of anthocyanin accumulation in response to far-red light in Arabidopsis ..
  3. Hiltbrunner A, Tscheuschler A, Viczian A, Kunkel T, Kircher S, Schafer E. FHY1 and FHL act together to mediate nuclear accumulation of the phytochrome A photoreceptor. Plant Cell Physiol. 2006;47:1023-34 pubmed
    ..The Arabidopsis genome contains five phytochromes (phyA-E), among which phyA and phyB play the most important roles...
  4. Yanovsky M, Luppi J, Kirchbauer D, Ogorodnikova O, Sineshchekov V, Adam E, et al. Missense mutation in the PAS2 domain of phytochrome A impairs subnuclear localization and a subset of responses. Plant Cell. 2002;14:1591-603 pubmed
    b>Phytochrome A signaling shows two photobiologically discrete outputs: so-called very-low-fluence responses (VLFR) and high-irradiance responses (HIR)...
  5. Bauer D, Viczian A, Kircher S, Nobis T, Nitschke R, Kunkel T, et al. Constitutive photomorphogenesis 1 and multiple photoreceptors control degradation of phytochrome interacting factor 3, a transcription factor required for light signaling in Arabidopsis. Plant Cell. 2004;16:1433-45 pubmed
    ..fashion, induces nuclear import of the plant photoreceptors phytochrome, promotes interaction of phytochrome A (phyA) and phyB with transcription factors including phytochrome interacting factor 3 (PIF3), and is thought ..
  6. Dieterle M, Bauer D, Buche C, Krenz M, Schafer E, Kretsch T. A new type of mutation in phytochrome A causes enhanced light sensitivity and alters the degradation and subcellular partitioning of the photoreceptor. Plant J. 2005;41:146-61 pubmed
    ..consisting of multiple treatments with alternating red and far-red light pulses was used to isolate mutants in phytochrome A-dependent signal transduction pathways in Arabidopsis...
  7. Choi G, Yi H, Lee J, Kwon Y, Soh M, Shin B, et al. Phytochrome signalling is mediated through nucleoside diphosphate kinase 2. Nature. 1999;401:610-3 pubmed
    ..These results indicate that NDPK2 is a positive signalling component of the phytochrome-mediated light-signal-transduction pathway in Arabidopsis. ..
  8. Viczian A, Adam E, Wolf I, Bindics J, Kircher S, Heijde M, et al. A short amino-terminal part of Arabidopsis phytochrome A induces constitutive photomorphogenic response. Mol Plant. 2012;5:629-41 pubmed publisher
    b>Phytochrome A (phyA) is the dominant photoreceptor of far-red light sensing in Arabidopsis thaliana...
  9. Han I, Tseng T, Eisinger W, Briggs W. Phytochrome A regulates the intracellular distribution of phototropin 1-green fluorescent protein in Arabidopsis thaliana. Plant Cell. 2008;20:2835-47 pubmed publisher
    ..This red light effect is mediated by phytochrome A and requires approximately 2 h in the dark at room temperature to go to completion...
  10. Oh S, Warnasooriya S, Montgomery B. Downstream effectors of light- and phytochrome-dependent regulation of hypocotyl elongation in Arabidopsis thaliana. Plant Mol Biol. 2013;81:627-40 pubmed publisher
    ..We identified and characterized genes whose expression is impacted by light and by phyA and phyB that have roles in the photoregulation of hypocotyl length...
  11. Trupkin S, Mora Garcia S, Casal J. The cyclophilin ROC1 links phytochrome and cryptochrome to brassinosteroid sensitivity. Plant J. 2012;71:712-23 pubmed publisher
    ..of the ROTAMASE CYCLOPHILIN 1 (ROC1/AtCYP18-3) gene, and partial loss-of function roc1 alleles, has defects in phytochrome A (phyA)-, cryptochrome 1 (cry1)- and phytochrome B (phyB)-mediated de-etiolation, including long hypocotyls ..
  12. Magliano T, Botto J, Godoy A, Symonds V, Lloyd A, Casal J. New Arabidopsis recombinant inbred lines (Landsberg erecta x Nossen) reveal natural variation in phytochrome-mediated responses. Plant Physiol. 2005;138:1126-35 pubmed
    ..Such flexibility in combination of responses is observed among accessions and could aid in the adjustment to different microenvironments. ..
  13. Ibarra S, Auge G, Sanchez R, Botto J. Transcriptional programs related to phytochrome A function in Arabidopsis seed germination. Mol Plant. 2013;6:1261-73 pubmed publisher
    In Arabidopsis seeds, germination is promoted only by phytochromes, principally phytochrome B (phyB) and phytochrome A (phyA)...
  14. Kirchenbauer D, Viczián A, Ádám Ã, Hegedűs Z, Klose C, Leppert M, et al. Characterization of photomorphogenic responses and signaling cascades controlled by phytochrome-A expressed in different tissues. New Phytol. 2016;211:584-98 pubmed publisher
    The photoreceptor phytochrome A acts as a light-dependent molecular switch and regulates responses initiated by very low fluences of light (VLFR) and high fluences (HIR) of far-red light...
  15. Chawla R, Nicholson S, Folta K, Srivastava V. Transgene-induced silencing of Arabidopsis phytochrome A gene via exonic methylation. Plant J. 2007;52:1105-18 pubmed
    ..Here, we report the isolation of a transcriptionally suppressed epi-allele of the Arabidopsis thaliana phytochrome A gene (PHYA) termed phyA' that shows methylation only in symmetric CG sites resident in exonic regions...
  16. Rangani G, Khodakovskaya M, Alimohammadi M, Hoecker U, Srivastava V. Site-specific methylation in gene coding region underlies transcriptional silencing of the Phytochrome A epiallele in Arabidopsis thaliana. Plant Mol Biol. 2012;79:191-202 pubmed publisher
    ..The role of gene body methylation in gene expression, however, is not clear. The Arabidopsis Phytochrome A epiallele, phyA', carries hypermethylation in several CG sites resident to the coding region...
  17. Usami T, Matsushita T, Oka Y, Mochizuki N, Nagatani A. Roles for the N- and C-terminal domains of phytochrome B in interactions between phytochrome B and cryptochrome signaling cascades. Plant Cell Physiol. 2007;48:424-33 pubmed
    ..In summary, these results demonstrate that different domains of phyB can play various roles which are dependent on light conditions as well as on the specific physiological response. ..
  18. Hetmann A, Wujak M, Kowalczyk S. Protein Transphosphorylation During the Mutual Interaction between Phytochrome A and a Nuclear Isoform of Nucleoside Diphosphate Kinase Is Regulated by Red Light. Biochemistry (Mosc). 2016;81:1153-1162 pubmed
    ..NDPK-In undergoes strong catalytic activation upon its interaction with the active form of phytochrome A (Pfr) in red light...
  19. Wei Q, Zhou W, Hu G, Wei J, Yang H, Huang J. Heterotrimeric G-protein is involved in phytochrome A-mediated cell death of Arabidopsis hypocotyls. Cell Res. 2008;18:949-60 pubmed publisher
    ..However, its role in phytochrome A (phyA) signaling remains elusive...
  20. Eprintsev A, Fedorin D, Sazonova O, Igamberdiev A. Light inhibition of fumarase in Arabidopsis leaves is phytochrome A-dependent and mediated by calcium. Plant Physiol Biochem. 2016;102:161-6 pubmed publisher
    ..observed that the main regulator of FUM1 gene transcription, encoding the mitochondrial form of fumarase, is phytochrome A. The active form of phytochrome A suppressed FUM1 expression, while the expression of the FUM2 gene encoding ..
  21. Paik I, Yang S, Choi G. Phytochrome regulates translation of mRNA in the cytosol. Proc Natl Acad Sci U S A. 2012;109:1335-40 pubmed publisher
    ..The present results demonstrate that phytochromes transmit light signals to regulate not only transcription in the nucleus through PIFs, but also translation in the cytosol through PNT1. ..
  22. Kaczorowski K, Quail P. Arabidopsis PSEUDO-RESPONSE REGULATOR7 is a signaling intermediate in phytochrome-regulated seedling deetiolation and phasing of the circadian clock. Plant Cell. 2003;15:2654-65 pubmed
    ..that exhibited reduced sensitivity to both continuous red and far-red light, suggesting involvement in both phyA and phyB signaling...
  23. Toledo Ortiz G, Kiryu Y, Kobayashi J, Oka Y, Kim Y, Nam H, et al. Subcellular sites of the signal transduction and degradation of phytochrome A. Plant Cell Physiol. 2010;51:1648-60 pubmed publisher
    ..Among the members of the phytochrome family, phytochrome A (phyA) exclusively mediates the far-red light high irradiance response (FR-HIR), which is elicited by ..
  24. Sung D, Lee D, Harris H, Raab A, Feldmann J, Meharg A, et al. Identification of an arsenic tolerant double mutant with a thiol-mediated component and increased arsenic tolerance in phyA mutants. Plant J. 2007;49:1064-75 pubmed
    ..contains a single T-DNA insertion, ars4, which co-segregates with arsenic tolerance and is inserted in the Phytochrome A (PHYA) gene, strongly reducing the expression of PHYA...
  25. Phee B, Shin D, Cho J, Kim S, Kim J, Lee Y, et al. Identification of phytochrome-interacting protein candidates in Arabidopsis thaliana by co-immunoprecipitation coupled with MALDI-TOF MS. Proteomics. 2006;6:3671-80 pubmed
    ..Using MALDI-TOF MS analysis, 7 of these candidates were predicted to be putative phytochrome A-interacting proteins and the remaining ones to be phytochrome B-interacting proteins...
  26. Debrieux D, Fankhauser C. Light-induced degradation of phyA is promoted by transfer of the photoreceptor into the nucleus. Plant Mol Biol. 2010;73:687-95 pubmed publisher
    ..The phytochrome family is composed of the light-labile phyA and several light-stable members (phyB-phyE in Arabidopsis)...
  27. Garg A, Sawers R, Wang H, Kim J, Walker J, Brutnell T, et al. Light-regulated overexpression of an Arabidopsis phytochrome A gene in rice alters plant architecture and increases grain yield. Planta. 2006;223:627-36 pubmed
    ..We report here the overexpression of Arabidopsis thaliana PHYTOCHROME A (PHYA) gene in a commercially important indica rice variety (Oryza sativa L. Pusa Basmati-1)...
  28. Shin D, Cho M, Kim T, Yoo J, Kim J, Han Y, et al. A small GTPase activator protein interacts with cytoplasmic phytochromes in regulating root development. J Biol Chem. 2010;285:32151-9 pubmed publisher
    ..PIRF1 also interacted with ROPs and activated them in a phytochrome-dependent manner. The Pr form of phytochrome A enhanced the RopGEF activity of PIRF1, whereas the Pfr form inhibited it...
  29. Fairchild C, Schumaker M, Quail P. HFR1 encodes an atypical bHLH protein that acts in phytochrome A signal transduction. Genes Dev. 2000;14:2377-91 pubmed
    ..specifically to continuous far-red light (FRc), thereby suggesting a locus likely to be involved in phytochrome A (phyA) signal transduction...
  30. Trupkin S, Debrieux D, Hiltbrunner A, Fankhauser C, Casal J. The serine-rich N-terminal region of Arabidopsis phytochrome A is required for protein stability. Plant Mol Biol. 2007;63:669-78 pubmed
    Deletion or substitution of the serine-rich N-terminal stretch of grass phytochrome A (phyA) has repeatedly been shown to yield a hyperactive photoreceptor when expressed under the control of a constitutive promoter in transgenic tobacco ..
  31. Chen F, Li B, Li G, Charron J, Dai M, Shi X, et al. Arabidopsis Phytochrome A Directly Targets Numerous Promoters for Individualized Modulation of Genes in a Wide Range of Pathways. Plant Cell. 2014;26:1949-1966 pubmed
    The far-red light (FR) photoreceptor phytochrome A (phyA) contains no DNA binding domain but associates with the CHALCONE SYNTHASE promoter through its chaperone FAR-RED ELONGATED HYPOCOTYL1 and transcription factors...
  32. Rattanapisit K, Cho M, Bhoo S. Lysine 206 in Arabidopsis phytochrome A is the major site for ubiquitin-dependent protein degradation. J Biochem. 2016;159:161-9 pubmed publisher
    b>Phytochrome A (phyA) is a light labile phytochrome that mediates plant development under red/far-red light condition. Degradation of phyA is initiated by red light-induced phyA-ubiquitin conjugation through the 26S proteasome pathway...
  33. Jang I, Henriques R, Chua N. Three transcription factors, HFR1, LAF1 and HY5, regulate largely independent signaling pathways downstream of phytochrome A. Plant Cell Physiol. 2013;54:907-16 pubmed publisher
    Among signaling components downstream of phytochrome A (phyA), HY5, HFR1 and LAF1 are transcription factors that regulate expression of phyA-responsive genes...
  34. Achard P, Liao L, Jiang C, Desnos T, Bartlett J, Fu X, et al. DELLAs contribute to plant photomorphogenesis. Plant Physiol. 2007;143:1163-72 pubmed
    ..We conclude that DELLAs are a major component of the adaptively significant mechanism via which light regulates plant growth during photomorphogenesis. ..
  35. Genoud T, Schweizer F, Tscheuschler A, Debrieux D, Casal J, Schafer E, et al. FHY1 mediates nuclear import of the light-activated phytochrome A photoreceptor. PLoS Genet. 2008;4:e1000143 pubmed publisher
    ..Light-induced nuclear import is required for most phytochrome responses. Nuclear accumulation of phyA is dependent on two related proteins called FHY1 (Far-red elongated HYpocotyl 1) and FHL (FHY1 Like), with FHY1 ..
  36. Wang X, Roig Villanova I, Khan S, Shanahan H, Quail P, Martinez Garcia J, et al. A novel high-throughput in vivo molecular screen for shade avoidance mutants identifies a novel phyA mutation. J Exp Bot. 2011;62:2973-87 pubmed publisher
    ..1 (dra1) mutant, that showed no avoidance of shade for the PHYB::LUC response, was the result of a mutation in the PHYA gene...
  37. Chen F, Shi X, Chen L, Dai M, Zhou Z, Shen Y, et al. Phosphorylation of FAR-RED ELONGATED HYPOCOTYL1 is a key mechanism defining signaling dynamics of phytochrome A under red and far-red light in Arabidopsis. Plant Cell. 2012;24:1907-20 pubmed publisher
    ..b>Phytochrome A (phyA) is the single dominant photoreceptor in young Arabidopsis thaliana seedlings that initiates ..
  38. Hwang Y, Quail P. Phytochrome-regulated PIL1 derepression is developmentally modulated. Plant Cell Physiol. 2008;49:501-11 pubmed publisher
    ..Analysis of phy-null mutants indicates that multiple phytochromes, including phyA and phyB, impose this repression...
  39. Su L, Hou P, Song M, Zheng X, Guo L, Xiao Y, et al. Synergistic and Antagonistic Action of Phytochrome (Phy) A and PhyB during Seedling De-Etiolation in Arabidopsis thaliana. Int J Mol Sci. 2015;16:12199-212 pubmed publisher
    ..However, the functional relationship between phyA and phyB is not fully understood under different kinds of light and in response to different intensities of such ..
  40. Yoo J, Cho M, Lee S, Bhoo S. Phytochrome-interacting ankyrin repeat protein 2 modulates phytochrome A-mediated PIF3 phosphorylation in light signal transduction. J Biochem. 2016;160:243-249 pubmed
    ..We found that PIA2 suppressed PIF3 phosphorylation by phyA. To elucidate how PIA2 modulates phyA-mediated PIF3 phosphorylation, we generated non-phosphorylation mutants and N-..
  41. Shen Y, Zhou Z, Feng S, Li J, Tan Wilson A, Qu L, et al. Phytochrome A mediates rapid red light-induced phosphorylation of Arabidopsis FAR-RED ELONGATED HYPOCOTYL1 in a low fluence response. Plant Cell. 2009;21:494-506 pubmed publisher
    b>Phytochrome A (phyA) is the primary photoreceptor for mediating the far-red high irradiance response in Arabidopsis thaliana...
  42. Sharrock R, Clack T. Heterodimerization of type II phytochromes in Arabidopsis. Proc Natl Acad Sci U S A. 2004;101:11500-5 pubmed
    ..No interaction of the epitope-tagged proteins with type I phyA was detected...
  43. Wang Y, Maruhnich S, Mageroy M, Justice J, Folta K. Phototropin 1 and cryptochrome action in response to green light in combination with other wavelengths. Planta. 2013;237:225-37 pubmed publisher
    ..The GL opposition of RL responses persists in phyA, phyB, cry1cry2 and phot2 mutants...
  44. Wu F, Fan C, Zhang X, Fu Y. The phytochrome gene family in soybean and a dominant negative effect of a soybean PHYA transgene on endogenous Arabidopsis PHYA. Plant Cell Rep. 2013;32:1879-90 pubmed publisher
    The evolutionary origin of the phytochrome genes in soybean was analyzed. The expression profiles of PHYA paralogs were characterized. The heterologous expression of GmPHYA1 in Arabidopsis resulted in longer hypocotyls...
  45. Oh E, Kim J, Park E, Kim J, Kang C, Choi G. PIL5, a phytochrome-interacting basic helix-loop-helix protein, is a key negative regulator of seed germination in Arabidopsis thaliana. Plant Cell. 2004;16:3045-58 pubmed
    ..PIL5 preferentially interacts with the Pfr forms of Phytochrome A (PhyA) and Phytochrome B (PhyB)...
  46. Rusaczonek A, Czarnocka W, Kacprzak S, Witoń D, Ślesak I, Szechyńska Hebda M, et al. Role of phytochromes A and B in the regulation of cell death and acclimatory responses to UV stress in Arabidopsis thaliana. J Exp Bot. 2015;66:6679-95 pubmed publisher
    ..The aim of this work was to evaluate a possible role of the red/far-red light photoreceptors phytochrome A (phyA) and phytochrome B (phyB) and their interrelations during acclimatory responses to UV stress...
  47. Balasubramanian S, Sureshkumar S, Agrawal M, Michael T, Wessinger C, Maloof J, et al. The PHYTOCHROME C photoreceptor gene mediates natural variation in flowering and growth responses of Arabidopsis thaliana. Nat Genet. 2006;38:711-5 pubmed
    ..thaliana. Our work, together with previous findings, suggests that photoreceptor genes are major agents of natural variation in plant flowering and growth response. ..
  48. Fankhauser C, Yeh K, Lagarias J, Zhang H, Elich T, Chory J. PKS1, a substrate phosphorylated by phytochrome that modulates light signaling in Arabidopsis. Science. 1999;284:1539-41 pubmed
    ..In vivo experiments suggest that PKS1 is phosphorylated in a phytochrome-dependent manner and negatively regulates phytochrome signaling. The data suggest that phytochromes signal by serine-threonine phosphorylation. ..
  49. Footitt S, Ölçer Footitt H, Hambidge A, Finch Savage W. A laboratory simulation of Arabidopsis seed dormancy cycling provides new insight into its regulation by clock genes and the dormancy-related genes DOG1, MFT, CIPK23 and PHYA. Plant Cell Environ. 2017;40:1474-1486 pubmed publisher
    ..DELAY OF GERMINATION 1 (DOG1), MOTHER OF FLOWERING TIME (MFT), CBL-INTERACTING PROTEIN KINASE 23 (CIPK23) and PHYTOCHROME A (PHYA)] and secondly, using further mutants, we test the hypothesis that components of the circadian clock are ..
  50. Seo H, Watanabe E, Tokutomi S, Nagatani A, Chua N. Photoreceptor ubiquitination by COP1 E3 ligase desensitizes phytochrome A signaling. Genes Dev. 2004;18:617-22 pubmed
    ..The phyA PAS domain interacts with the COP1 WD40 domain...
  51. Shen Y, Khanna R, Carle C, Quail P. Phytochrome induces rapid PIF5 phosphorylation and degradation in response to red-light activation. Plant Physiol. 2007;145:1043-51 pubmed
    The phytochrome (phy) family of sensory photoreceptors (phyA-phyE in Arabidopsis thaliana) induces changes in target-gene expression upon light-induced translocation to the nucleus, where certain members interact with selected members of ..
  52. Saijo Y, Zhu D, Li J, Rubio V, Zhou Z, Shen Y, et al. Arabidopsis COP1/SPA1 complex and FHY1/FHY3 associate with distinct phosphorylated forms of phytochrome A in balancing light signaling. Mol Cell. 2008;31:607-13 pubmed publisher
    ..Following light-triggered nuclear translocation, the photoreceptor phytochrome A (phyA) regulates gene expression under continuous far-red light and is rapidly destabilized upon red light ..
  53. Lu X, Zhou C, Xu P, Luo Q, Lian H, Yang H. Red-light-dependent interaction of phyB with SPA1 promotes COP1-SPA1 dissociation and photomorphogenic development in Arabidopsis. Mol Plant. 2015;8:467-78 pubmed publisher
    ..It has been demonstrated that SPA1 (SUPPRESSOR OF PHYTOCHROME A 1) associates with COP1 to promote COP1 activity and suppress photomorphogenesis...
  54. Dehesh K, Franci C, Parks B, Seeley K, Short T, Tepperman J, et al. Arabidopsis HY8 locus encodes phytochrome A. Plant Cell. 1993;5:1081-8 pubmed
    ..light (the so-called "far-red high-irradiance response") are selectively deficient in functional phytochrome A. To define the molecular lesion in these mutants, we sequenced the phytochrome A gene (phyA) in lines carrying ..
  55. Kami C, Hersch M, Trevisan M, Genoud T, Hiltbrunner A, Bergmann S, et al. Nuclear phytochrome A signaling promotes phototropism in Arabidopsis. Plant Cell. 2012;24:566-76 pubmed publisher
    ..phot1 is essential for phototropism in response to low light, a response that is also modulated by phytochrome A (phyA), representing a classical example of photoreceptor coaction...
  56. Molas M, Kiss J. PKS1 plays a role in red-light-based positive phototropism in roots. Plant Cell Environ. 2008;31:842-9 pubmed publisher
    ..exhibit positive phototropism relative to red light (RL), and this response is mediated by phytochromes A and B (phyA and phyB)...
  57. Brouwer B, Gardeström P, Keech O. In response to partial plant shading, the lack of phytochrome A does not directly induce leaf senescence but alters the fine-tuning of chlorophyll biosynthesis. J Exp Bot. 2014;65:4037-49 pubmed publisher
    ..is first shown here that, while PHYB is required to maintain chlorophyll content in a completely shaded plant, only PHYA is involved in maintaining the leaf chlorophyll content in response to partial plant shading...
  58. Ryu J, Kim J, Kunkel T, Kim B, Cho D, Hong S, et al. Phytochrome-specific type 5 phosphatase controls light signal flux by enhancing phytochrome stability and affinity for a signal transducer. Cell. 2005;120:395-406 pubmed
  59. Desai M, Hu J. Light induces peroxisome proliferation in Arabidopsis seedlings through the photoreceptor phytochrome A, the transcription factor HY5 HOMOLOG, and the peroxisomal protein PEROXIN11b. Plant Physiol. 2008;146:1117-27 pubmed publisher
    ..The far-red light receptor phytochrome A (phyA) and the bZIP transcription factor HY5 HOMOLOG (HYH) are both required for the up-regulation of PEX11b ..
  60. Debrieux D, Trevisan M, Fankhauser C. Conditional involvement of constitutive photomorphogenic1 in the degradation of phytochrome A. Plant Physiol. 2013;161:2136-45 pubmed publisher
    All higher plants possess multiple phytochrome photoreceptors, with phytochrome A (phyA) being light labile and other members of the family being relatively light stable (phyB-phyE in Arabidopsis [Arabidopsis thaliana])...
  61. Phee B, Kim J, Shin D, Yoo J, Park K, Han Y, et al. A novel protein phosphatase indirectly regulates phytochrome-interacting factor 3 via phytochrome. Biochem J. 2008;415:247-55 pubmed publisher
    ..protein, PAPP2C (phytochrome-associated protein phosphatase type 2C), interacts in the nucleus with phyA (phytochrome A) and phyB, both in vitro and in vivo...
  62. Salisbury F, Hall A, Grierson C, Halliday K. Phytochrome coordinates Arabidopsis shoot and root development. Plant J. 2007;50:429-38 pubmed
    ..This new link between phytochrome and auxin may go some way to explain the extensive overlap in responses mediated by these two developmental regulators. ..
  63. Correll M, Coveney K, Raines S, Mullen J, Hangarter R, Kiss J. Phytochromes play a role in phototropism and gravitropism in Arabidopsis roots. Adv Space Res. 2003;31:2203-10 pubmed
    ..b>Phytochrome A (phyA) and phyB mediate the positive red-light-based photoresponse in roots since single mutants (and the ..
  64. Devlin P, Kay S. Cryptochromes are required for phytochrome signaling to the circadian clock but not for rhythmicity. Plant Cell. 2000;12:2499-2510 pubmed
    ..We demonstrate that the phytochromes phyA, phyB, phyD, and phyE act as photoreceptors in red light input to the clock and that phyA and the cryptochromes ..
  65. Wolf I, Kircher S, Fejes E, Kozma Bognar L, Schafer E, Nagy F, et al. Light-regulated nuclear import and degradation of Arabidopsis phytochrome-A N-terminal fragments. Plant Cell Physiol. 2011;52:361-72 pubmed publisher
    The photoreceptor phytochrome-A (phyA) regulates germination and seedling establishment by mediating very low fluence (VLFR) and far-red high irradiance (FR-HIR) responses in Arabidopsis thaliana...
  66. Jang I, Chung P, Hemmes H, Jung C, Chua N. Rapid and reversible light-mediated chromatin modifications of Arabidopsis phytochrome A locus. Plant Cell. 2011;23:459-70 pubmed publisher
    ..b>Phytochrome A (phyA) is the major photoreceptor of deetiolation, and phyA expression is reversibly repressed by light...
  67. Ahmad M, Jarillo J, Smirnova O, Cashmore A. The CRY1 blue light photoreceptor of Arabidopsis interacts with phytochrome A in vitro. Mol Cell. 1998;1:939-48 pubmed
    ..photoreceptors, that Arabidopsis CRY1 and CRY2 (cryptochrome) are substrates for phosphorylation by a phytochrome A-associated kinase activity...
  68. Nito K, Wong C, Yates J, Chory J. Tyrosine phosphorylation regulates the activity of phytochrome photoreceptors. Cell Rep. 2013;3:1970-9 pubmed publisher
    ..The proper response to changes in the light environment is crucial for plant survival, and our study brings tyrosine phosphorylation to the forefront of light-signaling mechanisms. ..
  69. Weidler G, Zur Oven Krockhaus S, Heunemann M, Orth C, Schleifenbaum F, Harter K, et al. Degradation of Arabidopsis CRY2 is regulated by SPA proteins and phytochrome A. Plant Cell. 2012;24:2610-23 pubmed publisher
    ..Consistent with a role of SPA proteins in phytochrome A (phyA) signaling, a phyA mutant had enhanced cry2 levels, particularly under low fluence rate blue light...
  70. Robson F, Okamoto H, Patrick E, Harris S, Wasternack C, Brearley C, et al. Jasmonate and phytochrome A signaling in Arabidopsis wound and shade responses are integrated through JAZ1 stability. Plant Cell. 2010;22:1143-60 pubmed publisher
    ..display exaggerated shade responses to low, but not high, R/FR ratio light, suggesting a role for JA in phytochrome A (phyA) signaling...
  71. Yang S, Jang I, Henriques R, Chua N. FAR-RED ELONGATED HYPOCOTYL1 and FHY1-LIKE associate with the Arabidopsis transcription factors LAF1 and HFR1 to transmit phytochrome A signals for inhibition of hypocotyl elongation. Plant Cell. 2009;21:1341-59 pubmed publisher
    Among the five phytochromes in Arabidopsis thaliana, phytochrome A (phyA) plays a major role in seedling deetiolation...
  72. Sheerin D, Menon C, Zur Oven Krockhaus S, Enderle B, Zhu L, Johnen P, et al. Light-activated phytochrome A and B interact with members of the SPA family to promote photomorphogenesis in Arabidopsis by reorganizing the COP1/SPA complex. Plant Cell. 2015;27:189-201 pubmed publisher
    ..Here, we show that light-activated phytochrome A (phyA) and phytochrome B (phyB) interact with SPA1 and other SPA proteins...
  73. Huq E, Quail P. PIF4, a phytochrome-interacting bHLH factor, functions as a negative regulator of phytochrome B signaling in Arabidopsis. EMBO J. 2002;21:2441-50 pubmed
    ..factor 4), which binds selectively to the biologically active Pfr form of phyB, but has little affinity for phyA. Despite its hypersensitive morphological phenotype, the srl2 mutant displays no perturbation of light-induced ..
  74. Shen Y, Kim J, Song P. NDPK2 as a signal transducer in the phytochrome-mediated light signaling. J Biol Chem. 2005;280:5740-9 pubmed
    ..2 in Arabidopsis has been identified as a phytochrome-interacting protein by using the C-terminal domain of phytochrome A (PhyA) as the bait in yeast two-hybrid screening...
  75. Sokolova V, Bindics J, Kircher S, Adam E, Schafer E, Nagy F, et al. Missense mutation in the amino terminus of phytochrome A disrupts the nuclear import of the photoreceptor. Plant Physiol. 2012;158:107-18 pubmed publisher
    Phytochromes are the red/far-red photoreceptors in higher plants. Among them, phytochrome A (PHYA) is responsible for the far-red high-irradiance response and for the perception of very low amounts of light, initiating the very-low-..