PEN3

Summary

Gene Symbol: PEN3
Description: ABC-2 and Plant PDR ABC-type transporter family protein
Alias: ABCG36, ARABIDOPSIS PLEIOTROPIC DRUG RESISTANCE 8, ARABIDOPSIS THALIANA ATP-BINDING CASSETTE G36, ATABCG36, ATP-BINDING CASSETTE G36, ATP-binding cassette G36, ATPDR8, Arabidopsis thaliana ATP-binding cassette G36, F23H11.19, F23H11_19, PDR8, PENETRATION 3, PLEIOTROPIC DRUG RESISTANCE 8, ABC-2 and Plant PDR ABC-type transporter family protein
Species: thale cress
Products:     PEN3

Top Publications

  1. Underwood W, Somerville S. Perception of conserved pathogen elicitors at the plasma membrane leads to relocalization of the Arabidopsis PEN3 transporter. Proc Natl Acad Sci U S A. 2013;110:12492-7 pubmed publisher
    The Arabidopsis penetration resistance 3 (PEN3) ATP binding cassette transporter participates in nonhost resistance to fungal and oomycete pathogens and is required for full penetration resistance to the barley powdery mildew Blumeria ..
  2. Mao H, Aryal B, Langenecker T, Hagmann J, Geisler M, Grebe M. Arabidopsis BTB/POZ protein-dependent PENETRATION3 trafficking and disease susceptibility. Nat Plants. 2017;3:854-858 pubmed publisher
    ..The epidermal outer plasma membrane domain harbours the PENETRATION3 (PEN3)/ABCG36/PDR8 ATP-binding cassette transporter that confers non-host resistance to several pathogens...
  3. Consonni C, Humphry M, Hartmann H, Livaja M, Durner J, Westphal L, et al. Conserved requirement for a plant host cell protein in powdery mildew pathogenesis. Nat Genet. 2006;38:716-20 pubmed
  4. Strader L, Bartel B. The Arabidopsis PLEIOTROPIC DRUG RESISTANCE8/ABCG36 ATP binding cassette transporter modulates sensitivity to the auxin precursor indole-3-butyric acid. Plant Cell. 2009;21:1992-2007 pubmed publisher
    ..This mutant is defective in PLEIOTROPIC DRUG RESISTANCE8 (PDR8)/PENETRATION3/ABCG36, a plasma membrane-localized ATP binding cassette transporter that has established roles in pathogen responses and ..
  5. Kim D, Jin J, Alejandro S, Martinoia E, Lee Y. Overexpression of AtABCG36 improves drought and salt stress resistance in Arabidopsis. Physiol Plant. 2010;139:170-80 pubmed publisher
    ..longer than 5 weeks, transgenic Arabidopsis plants that overexpress an ATP-binding cassette (ABC) transporter, AtABCG36/AtPDR8, produced higher shoot biomass and less chlorotic leaves than the wild-type...
  6. Kobae Y, Sekino T, Yoshioka H, Nakagawa T, Martinoia E, Maeshima M. Loss of AtPDR8, a plasma membrane ABC transporter of Arabidopsis thaliana, causes hypersensitive cell death upon pathogen infection. Plant Cell Physiol. 2006;47:309-18 pubmed
    Plants contain a large number of ATP-binding cassette (ABC) transporters belonging to different subclasses. AtPDR8 is the only member of the pleiotropic drug resistance (PDR) ABC transporter subclass in Arabidopsis that is constitutively ..
  7. Lu X, Dittgen J, Piślewska Bednarek M, Molina A, Schneider B, Svatoš A, et al. Mutant Allele-Specific Uncoupling of PENETRATION3 Functions Reveals Engagement of the ATP-Binding Cassette Transporter in Distinct Tryptophan Metabolic Pathways. Plant Physiol. 2015;168:814-27 pubmed publisher
    ..b>PEN3 encodes a plasma membrane-resident pleiotropic drug resistance-type ATP-binding cassette transporter and is thought ..
  8. Loehrer M, Langenbach C, Goellner K, Conrath U, Schaffrath U. Characterization of nonhost resistance of Arabidopsis to the Asian soybean rust. Mol Plant Microbe Interact. 2008;21:1421-30 pubmed publisher
    ..Double mutants affected in either jasmonic acid or salicylic acid signaling in the pen3-1 background revealed the involvement of both pathways in nonhost resistance (NHR) of Arabidopsis to P. pachyrhizi...
  9. Ruzicka K, Strader L, Bailly A, Yang H, Blakeslee J, Langowski L, et al. Arabidopsis PIS1 encodes the ABCG37 transporter of auxinic compounds including the auxin precursor indole-3-butyric acid. Proc Natl Acad Sci U S A. 2010;107:10749-53 pubmed publisher
    ..ABCG37 and its homolog ABCG36 act redundantly at outermost root plasma membranes and, unlike established IAA transporters from the PIN and ABCB ..
  10. Xin X, Nomura K, Underwood W, He S. Induction and suppression of PEN3 focal accumulation during Pseudomonas syringae pv. tomato DC3000 infection of Arabidopsis. Mol Plant Microbe Interact. 2013;26:861-7 pubmed publisher
    ..b>AtPDR8, also called PEN3, is required for penetration resistance of Arabidopsis to nonadapted powdery mildew fungi...

Detail Information

Publications15

  1. Underwood W, Somerville S. Perception of conserved pathogen elicitors at the plasma membrane leads to relocalization of the Arabidopsis PEN3 transporter. Proc Natl Acad Sci U S A. 2013;110:12492-7 pubmed publisher
    The Arabidopsis penetration resistance 3 (PEN3) ATP binding cassette transporter participates in nonhost resistance to fungal and oomycete pathogens and is required for full penetration resistance to the barley powdery mildew Blumeria ..
  2. Mao H, Aryal B, Langenecker T, Hagmann J, Geisler M, Grebe M. Arabidopsis BTB/POZ protein-dependent PENETRATION3 trafficking and disease susceptibility. Nat Plants. 2017;3:854-858 pubmed publisher
    ..The epidermal outer plasma membrane domain harbours the PENETRATION3 (PEN3)/ABCG36/PDR8 ATP-binding cassette transporter that confers non-host resistance to several pathogens...
  3. Consonni C, Humphry M, Hartmann H, Livaja M, Durner J, Westphal L, et al. Conserved requirement for a plant host cell protein in powdery mildew pathogenesis. Nat Genet. 2006;38:716-20 pubmed
  4. Strader L, Bartel B. The Arabidopsis PLEIOTROPIC DRUG RESISTANCE8/ABCG36 ATP binding cassette transporter modulates sensitivity to the auxin precursor indole-3-butyric acid. Plant Cell. 2009;21:1992-2007 pubmed publisher
    ..This mutant is defective in PLEIOTROPIC DRUG RESISTANCE8 (PDR8)/PENETRATION3/ABCG36, a plasma membrane-localized ATP binding cassette transporter that has established roles in pathogen responses and ..
  5. Kim D, Jin J, Alejandro S, Martinoia E, Lee Y. Overexpression of AtABCG36 improves drought and salt stress resistance in Arabidopsis. Physiol Plant. 2010;139:170-80 pubmed publisher
    ..longer than 5 weeks, transgenic Arabidopsis plants that overexpress an ATP-binding cassette (ABC) transporter, AtABCG36/AtPDR8, produced higher shoot biomass and less chlorotic leaves than the wild-type...
  6. Kobae Y, Sekino T, Yoshioka H, Nakagawa T, Martinoia E, Maeshima M. Loss of AtPDR8, a plasma membrane ABC transporter of Arabidopsis thaliana, causes hypersensitive cell death upon pathogen infection. Plant Cell Physiol. 2006;47:309-18 pubmed
    Plants contain a large number of ATP-binding cassette (ABC) transporters belonging to different subclasses. AtPDR8 is the only member of the pleiotropic drug resistance (PDR) ABC transporter subclass in Arabidopsis that is constitutively ..
  7. Lu X, Dittgen J, Piślewska Bednarek M, Molina A, Schneider B, Svatoš A, et al. Mutant Allele-Specific Uncoupling of PENETRATION3 Functions Reveals Engagement of the ATP-Binding Cassette Transporter in Distinct Tryptophan Metabolic Pathways. Plant Physiol. 2015;168:814-27 pubmed publisher
    ..b>PEN3 encodes a plasma membrane-resident pleiotropic drug resistance-type ATP-binding cassette transporter and is thought ..
  8. Loehrer M, Langenbach C, Goellner K, Conrath U, Schaffrath U. Characterization of nonhost resistance of Arabidopsis to the Asian soybean rust. Mol Plant Microbe Interact. 2008;21:1421-30 pubmed publisher
    ..Double mutants affected in either jasmonic acid or salicylic acid signaling in the pen3-1 background revealed the involvement of both pathways in nonhost resistance (NHR) of Arabidopsis to P. pachyrhizi...
  9. Ruzicka K, Strader L, Bailly A, Yang H, Blakeslee J, Langowski L, et al. Arabidopsis PIS1 encodes the ABCG37 transporter of auxinic compounds including the auxin precursor indole-3-butyric acid. Proc Natl Acad Sci U S A. 2010;107:10749-53 pubmed publisher
    ..ABCG37 and its homolog ABCG36 act redundantly at outermost root plasma membranes and, unlike established IAA transporters from the PIN and ABCB ..
  10. Xin X, Nomura K, Underwood W, He S. Induction and suppression of PEN3 focal accumulation during Pseudomonas syringae pv. tomato DC3000 infection of Arabidopsis. Mol Plant Microbe Interact. 2013;26:861-7 pubmed publisher
    ..b>AtPDR8, also called PEN3, is required for penetration resistance of Arabidopsis to nonadapted powdery mildew fungi...
  11. Crouzet J, Trombik T, Fraysse A, Boutry M. Organization and function of the plant pleiotropic drug resistance ABC transporter family. FEBS Lett. 2006;580:1123-30 pubmed
    ..Only a single subfamily II member has been characterized. Induction of its expression by iron deficiency suggests its involvement in iron deficiency stress, thus, enlightening a new physiological role for a PDR gene...
  12. Kim D, Bovet L, Maeshima M, Martinoia E, Lee Y. The ABC transporter AtPDR8 is a cadmium extrusion pump conferring heavy metal resistance. Plant J. 2007;50:207-18 pubmed
    Cadmium (Cd) and lead (Pb) are widespread pollutants that are toxic to plant growth. The expression of AtPDR8 was upregulated in cadmium- or lead-treated Arabidopsis thaliana...
  13. Clay N, Adio A, Denoux C, Jander G, Ausubel F. Glucosinolate metabolites required for an Arabidopsis innate immune response. Science. 2009;323:95-101 pubmed publisher
    ..Two genes, PEN2 and PEN3, are also necessary for resistance to pathogens and are required for both callose deposition and glucosinolate ..
  14. Stein M, Dittgen J, Sánchez Rodríguez C, Hou B, Molina A, Schulze Lefert P, et al. Arabidopsis PEN3/PDR8, an ATP binding cassette transporter, contributes to nonhost resistance to inappropriate pathogens that enter by direct penetration. Plant Cell. 2006;18:731-46 pubmed
    ..Screening for Arabidopsis mutants deficient in resistance to barley powdery mildew identified PENETRATION3 (PEN3). pen3 plants permitted both increased invasion into epidermal cells and initiation of hyphae by B. g...
  15. Mao H, Nakamura M, Viotti C, Grebe M. A Framework for Lateral Membrane Trafficking and Polar Tethering of the PEN3 ATP-Binding Cassette Transporter. Plant Physiol. 2016;172:2245-2260 pubmed
    ..Here, we demonstrate that ACTIN7 (ACT7) mediates trafficking of the PENETRATION3 (PEN3) outer membrane protein from the trans-Golgi network (TGN) to the plasma membrane in the root epidermis of ..